D0934 | fenvalerate
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 32.06±0.00 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 35.48 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | rat | hepatocytes | MMP assay | Negative | IC50 | 163 | ||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Danger |
Aggregated GHS information provided by 216 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 5 of 216 companies. For more detailed information, please visit ECHA C&L website Of the 6 notification(s) provided by 211 of 216 companies with hazard statement code(s): H301 (92.89%): Toxic if swallowed [Danger Acute toxicity, oral] H315 (91%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (91%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (91%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H400 (25.59%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (98.58%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P264, P270, P271, P273, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Danger |
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P261, P264, P270, P271, P273, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Danger |
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P261, P264, P270, P271, P273, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Warning |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H332: Harmful if inhaled [Warning Acute toxicity, inhalation] H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure] H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] |
P260, P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P312, P304+P340, P309+P311, P312, P314, P321, P330, P333+P313, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| domestic animals - goat/sheep | LD50 | oral | > 1600mg/kg (1600mg/kg) | "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A207, Pg. 1984, | |
| quail | LD50 | oral | > 4gm/kg (4000mg/kg) | Journal of Toxicology and Environmental Health. Vol. 10, Pg. 307, 1982. | |
| dog | LD50 | oral | > 1gm/kg (1000mg/kg) | Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 6, 1978. | |
| mouse | LDLo | intracrebral | 200ug/kg (0.2mg/kg) | Toxicology and Applied Pharmacology. Vol. 66, Pg. 290, 1982. | |
| rabbit | LD50 | skin | 2500mg/kg (2500mg/kg) | Farm Chemicals Handbook. Vol. -, Pg. C138, 1991. | |
| mouse | LD50 | intraperitoneal | > 500mg/kg (500mg/kg) | Journal of Agricultural and Food Chemistry. Vol. 26, Pg. 954, 1978. | |
| rat | LD50 | skin | > 5gm/kg (5000mg/kg) | Pesticide Manual. Vol. 9, Pg. 388, 1991. | |
| mouse | LD50 | oral | 185mg/kg (185mg/kg) | Fundamental and Applied Toxicology. Vol. 5, Pg. 278, 1985. | |
| rat | LDLo | intravenous | 50mg/kg (50mg/kg) | Archives of Toxicology. Vol. 45, Pg. 325, 1980. | |
| rat | LD50 | oral | 70200ug/kg (70.2mg/kg) | Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. Vol. 21, Pg. 215, 1987. | |
| rat | LD50 | unreported | 202mg/kg (202mg/kg) | Indian Journal of Experimental Biology. Vol. 29, Pg. 176, 1991. | |
| chicken | LDLo | oral | 2400mg/kg (2400mg/kg) | Indian Veterinary Journal. Vol. 58, Pg. 941, 1981. | |
| mammal (species unspecified) | LD50 | unreported | 451mg/kg (451mg/kg) | brain and coverings: recordings from specific areas of cns | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(4), Pg. 70, 1988. |
| (+)-alpha-Cyano-3-phenoxybenzyl-(+)-alpha-(4-chlorophenyl)isovalerate | (+-)-4-Chloro-alpha-(1-methylethyl)benzeneacetic acid cyano(3-phenoxyphenyl)methyl ester | (+-)-Fenvalerate |
| (Cyano(3-phenoxyphenyl)methyl-4-chloro-alpha-(1-methylethyl)phenylacetate) | (RS)-alpha-Cyano-3-phenoxybenzyl (RS)-2-(4-chloro-phenyl)-3-methylbutyrate | (RS)-alpha-Cyano-3-phenoxybenzyl (RS)-2-(4-chlorophenyl)-3-methylbutyrate |
| (S)-.alpha.-Cyano-3-phenoxybenzyl(S)-2-(4-chlorophenyl)-3-methylbutyrate | (S)-alpha-Cyano-3-phenoxybenzyl(S)-2-(4-chlorophenyl)isovalerate | 4-Chloro-alpha-(1-methylethyl)benzeneacetic acid cyano(3-phenoxyphenyl)methyl ester |
| 51630-58-1 | 533-EP2274983A1 | 533-EP2275422A1 |
| 533-EP2280009A1 | 533-EP2292608A1 | 533-EP2305658A1 |
| 533-EP2308857A1 | 533-EP2308858A1 | 533-EP2311816A1 |
| 533-EP2311817A1 | 533-EP2314583A1 | 630F581 |
| 67614-32-8 | 67614-33-9 | AC-22281 |
| ACM1246815008 | AI3-29235 | AKOS015904814 |
| AS-49365 | AX8021157 | Acadrex (TN) |
| Agrofen | Aqmatrine | Asana |
| Asana XL | BMK1-H10 | BRN 2025982 |
| BRN 5857755 | Belmark | Benzeneacetic acid, 4-chloro-.alpha.-(1-methylethyl)-, (R)-cyano(3-phenoxyphenyl)methyl ester, (.alpha.S)- |
| Benzeneacetic acid, 4-chloro-.alpha.-(1-methylethyl)-, (S)-cyano(3-phenoxyphenyl)methyl ester, (.alpha.S)- | Benzeneacetic acid, 4-chloro-.alpha.-(1-methylethyl)-, cyano (3-phenoxyphenyl)methyl ester,(S-(R*,R*))- | Benzeneacetic acid, 4-chloro-.alpha.-(1-methylethyl)-, cyano(3-phenoxyphenyl)methyl ester |
| Benzeneacetic acid, 4-chloro-alpha-(1-methylethyl)-, cyano(3-phenoxyphenyl)methyl ester | Benzeneacetic acid, 4-chloro-alpha-(1-methylethyl)-, cyano(3-phenoxyphenyl)methyl ester, (+-)- | Benzeneacetic acid, 4-chloro-alpha-(1-methylethyl)-, cyano(3-phenoxyphenyl)methyl ester, (R-(R*,R*))- |
| Benzeneacetic acid, 4-chloro-alpha-(1-methylethyl)-, cyano(3-phenoxyphenyl)methyl ester, (R-(R*,S*))- | Benzeneacetic acid, 4-chloro-alpha-(1-methylethyl)-, cyano(3-phenoxyphenyl)methyl ester, (S-(R*,S*))- | Benzeneacetic acid, 4-chloro-alpha-(1-methylethyl)-, cyano(3-phenoxyphenyl)methyl ester,(R-(R*,S*))-; |
| C-22054 | C10988 | C25H22ClNO3 |
| CAS-51630-58-1 | CC-28411 | CCRIS 311 |
| CHEBI:5014 | CHEMBL492491 | CTK8E5624 |
| CY15763600 | Caswell No. 077A | Cyano (3-phenoxybenzyl)-2-(4-chlorophenyl)-3-methylbutyrate |
| Cyano(3-phenoxybenzyl)methyl 2-(4-chlorophenyl)-3-methylbutyrate | Cyano(3-phenoxyphenyl)methyl 2-(4-chlorophenyl)-3-methylbutanoate | Cyano(3-phenoxyphenyl)methyl 2-(4-chlorophenyl)-3-methylbutanoate # |
| Cyano(3-phenoxyphenyl)methyl 4-chloro-a-(1-methylethyl)benzeneacetate, 9CI | Cyano(3-phenoxyphenyl)methyl 4-chloro-alpha-(1-methylethyl)benzeneacetate | Cyano(3-phenoxyphenyl)methyl ester, 4-chloro-alpha-(1-methylethyl)benzeneacetic acid |
| D07952 | DSSTox_CID_621 | DSSTox_GSID_20621 |
| DSSTox_RID_75696 | DTXSID3020621 | EINECS 257-326-3 |
| EPA Shaughnessy Code: 109301 | Ectrin | Evercide 2362 |
| FT-0630648 | Fenaxin | Fenkem |
| Fenkill | Fenoxin | Fenval |
| Fenvalerate (BAN) | Fenvalerate (pydrin) | Fenvalerate .alpha. |
| Fenvalerate 10 microg/mL in Acetonitrile | Fenvalerate 10 microg/mL in Isooctane | Fenvalerate 100 microg/mL in Isooctane |
| Fenvalerate A .alpha. | Fenvalerate A-beta | Fenvalerate E.C. |
| Fenvalerate [BSI:ISO] | Fenvalerate [INN:BAN] | Fenvalerate, >=97% |
| Fenvalerate, PESTANAL(R), analytical standard | Fenvalerate, certified reference material, TraceCERT(R) | Fenvalerate-d5 |
| Furitrothion | GL6974 | Gold crest tribute |
| H653 | HSCI1_000043 | HSDB 6640 |
| Halmark | Insectral | LS-28682 |
| LS-28683 | LS-28685 | LS-7394 |
| MFCD00055324 | NCGC00163508-01 | NCGC00163508-02 |
| NCGC00163508-03 | NCGC00256483-01 | NCGC00259387-01 |
| NIOSH/CY1576360 | NYPJDWWKZLNGGM-UHFFFAOYSA-N | OMS 3023 |
| OMS-2000 | Phenoxin | Phenvalerate |
| Pydrin | Q412010 | S 1844 |
| S 5602 | S 5602 A .alpha. | S 5602A-beta |
| S 5602B-alpha | S 5602B-beta | S-5602 |
| SC-18544 | SCHEMBL26911 | SD 43775 |
| Sanmarton | Sumi-.alpha. | Sumi-alfa |
| Sumibac | Sumicidin | Sumicidin 20E |
| Sumicidin A .alpha. | Sumifleece | Sumifly |
| Sumipower | Sumitick | Sumkidin |
| TR-018390 | Tirade | Tox21_201838 |
| Tox21_302957 | Tribute | W-111022 |
| WL 43775 | [(S)-cyano-(3-phenoxyphenyl)methyl] (2R)-2-(4-chlorophenyl)-3-methylbutanoate | [cyano-(3-phenoxyphenyl)methyl] 2-(4-chlorophenyl)-3-methylbutanoate |
| a-Cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methylbutyrate | alpha-Cyano-(3-phenoxyphenyl)methyl-4-chloro-alpha-(1-methylethyl)benzeneacetate | alpha-Cyano-3-phenoxybenzyl 2-(4-chlorophenyl)isovalerate |
| alpha-Cyano-3-phenoxybenzyl alpha-(4-chlorophenyl)-iso-valerate | alpha-Cyano-3-phenoxybenzyl alpha-(4-chlorophenyl)isovalerate | alpha-Cyano-3-phenoxybenzyl alpha-isopropyl-4-chlorophenylacetate |
| alpha-Cyano-3-phenoxybenzyl-2-(4-chlorophenyl)-3-methylbutyrate | alpha-Cyano-3-phenoxybenzyl-alpha-(4-chlorophenyl)isovalerate | alpha-cyano-3-phenoxy-benzyl 2-(p-chlorophenyl)-2-isopropyl-acetate |
| alpha-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3- methylbutyrate | alpha-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methylbutanoate | alpha-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methylbutyrate |
| alpha-cyano-3-phenoxybenzyl alpha-isopropyl-4-chlorophenyl acetate | alpha-cyano-m-phenoxybenzyl 2-(p-chlorophenyl)-3-methylbutyrate | cyano[3-(phenyloxy)phenyl]methyl 2-(4-chlorophenyl)-3-methylbutanoate |
| fenvaierate | fenvalarate | fenvalerate |
| pydrin, (R-(R*,S*))-isomer |