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Drug

D0940 | fluocinonide

Molecular Formula C26H32F2O7
Molecular Weight 494.5
Structure
State solid
Route of elimination Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys.
Absorption The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. In general, percutaneous absorption is minimal.

D

C

D07CC05 Fluocinonide and antibiotics


[D07CC] Corticosteroids, potent, combinations with antibiotics


[D07C] CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS


[D07] CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS


[D] Dermatological drugs

D07AC08 Fluocinonide


[D07AC] Corticosteroids, potent (group III)


[D07A] CORTICOSTEROIDS, PLAIN


[D07] CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS


[D] Dermatological drugs

C05AA11 Fluocinonide


[C05AA] Corticosteroids


[C05A] AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE


[C05] VASOPROTECTIVES


[C] Cardiovascular system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL human qHTS-HepG2 MMP assay Negative IC50 163
MEMBRANE POTENTIAL human HepG2 MMP assay Negative IC50 163
MEMBRANE POTENTIAL rat hepatocytes MMP assay Negative IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 42 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]


H361 (97.62%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P201, P202, P264, P270, P281, P301+P310, P308+P313, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • (6ALPHA,11BETA,16ALPHA)-21-(ACETYLOXY)-6,9-DIFLUORO-11-HYDROXY-16,17-[(1-METHYLETHYLIDENE)BIS(OXY)]-PREGNA-1,4-DIENE-3,20-DIONE 1,4-PREGNADIEN-6ALPHA,9ALPHA-DIFLUORO-11BETA,16ALPHA,17,21-TETROL-3,20-DIONE 16,17-ACETONIDE 21-ACETATE 2-((2S,6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-2,6b-difluoro-7-hydroxy-6a,8a,10,10-tetramethyl-4-oxo-1,2,4,6a,6b,7,8,8a,11a,12,12a,12b-dodecahydro-8bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoethyl acetate
    2-[(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-8-yl]-2-oxoethyl acetate; 20527-EP2371811A2 2W4A77YPAN
    356-12-7 356F127 6alpha,9-Difluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone, 21-acetate
    AB2000697 ABP000638 AC-2071
    AKOS015896516 API0002731 BCP9000697
    BPBio1_000934 BRD-K57886322-001-03-4 BRD-K57886322-001-12-5
    BSPBio_000848 Bestasone Biscosal
    C07007 C26H32F2O7 CAS-356-12-7
    CCG-220774 CHEBI:5109 CHEMBL1501
    CS-2601 Cortalar D00325
    DB01047 DSSTox_CID_25307 DSSTox_GSID_45307
    DSSTox_RID_80793 DTXSID8045307 EINECS 206-597-6
    FLUOCINOMIDE ACETATE FLUOCINONIDE ACETONIDE 21-ACETATE Fluocinolide
    Fluocinolide acetate Fluocinolone acetonide 21-acetate Fluocinolone acetonide acetate
    Fluocinonide (JP17/USP/INN) Fluocinonide (Vanos) Fluocinonide Emulsified Base
    Fluocinonide FAPG Fluocinonide [USAN:BAN:INN:JAN] Fluocinonide [USAN:INN:BAN:JAN]
    Fluocinonide [USAN:USP:INN:BAN:JAN] Fluocinonide(Vanos) Fluocinonide(Vanos)/
    Fluocinonide, >=98% (HPLC) Fluocinonide, United States Pharmacopeia (USP) Reference Standard Fluocinonide, micronised
    Fluocinonido Fluocinonido [INN-Spanish] Fluocinonidum
    Fluocinonidum [INN-Latin] Fluonex Fluonex;Lidex;Lidex-E;Lonide;Lyderm;Vanos
    GTPL7078 HMS1570K10 HMS2097K10
    HMS2234H04 HMS3259N05 HMS3714K10
    HY-B0485 LIDEX (TN) LIDEX-E
    LS-118446 Lidex Lidex E
    Lonide Lyderm MFCD00079302
    MLS000028476 Metosyn NC00621
    NCGC00016436-01 NCGC00022398-03 NCGC00022398-05
    NSC 101791 Opera_ID_1780 Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-
    Pregna-1,4-diene-3,20-dione, 6-alpha, 9-difluoro-11-beta,16-alpha,17,21-tetrahydroxy-, cyclic17-acetal with acetone, 21-acetate Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone, 21-acetate Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone, 21-acetate (8CI)
    Prestwick0_000774 Prestwick1_000774 Prestwick2_000774
    Prestwick3_000774 Prestwick_1066 Q5462791
    SC-78862 SCHEMBL4262 SMR000058331
    SPBio_002787 SR-01000003097 SR-01000003097-3
    Straderm Synalar acetate Topsymin
    Topsyn Tox21_110438 Tox21_110438_1
    UNII-2W4A77YPAN Vanos Vanos (TN)
    W-106660 YF10077 ZINC3977978
    fluocinonide s2608

    DrugBank Name fluocinonide
    DrugBank DB01047
    CAS Number 356-12-7
    PubChem Compound 9642
    KEGG Compound ID C07007
    KEGG Drug D00325
    ChEBI 5109