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Compound

D0945 | fluvastatin

Molecular Formula C24H26FNO4
Molecular Weight 411.5
Structure
Trade names Lescol
Description statin; antilipemic; competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase ( conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis); reduce plasma cholesterol levels

C

C10AA04 Fluvastatin


[C10AA] HMG CoA reductase inhibitors


[C10A] LIPID MODIFYING AGENTS, PLAIN


[C10] LIPID MODIFYING AGENTS


[C] Cardiovascular system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
OPENING OF PERMEABILITY TRANSITION PORE (PTP) 10 µM 1 hour Human HepG2 High-content screening assay Decrease MEC 306
MEMBRANE POTENTIAL 27.64±1.87 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL human HepG2 MMP assay Negative IC50 163
MEMBRANE POTENTIAL rat hepatocytes MMP assay Negative IC50 163
MEMBRANE POTENTIAL >100 µM 1 hour Human HepG2 High-content screening assay Negative MEC 306
ROS PRODUCTION 50 µM 1 hour Human HepG2 High-content screening assay Increase MEC 306

Target Dose Time Species Model Method Action Positive criterion Reference
Reactive oxygen species 50 µM 1 hour Human HepG2 High-content screening assay increase MEC 306

Pictogram Signal Statements Precautionary Statement Codes
Danger

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.


H350 (100%): May cause cancer [Danger Carcinogenicity]


 P201, P202, P281, P308+P313, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]


H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]


H412 (100%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]


 P264, P270, P273, P280, P301+P312, P302+P352, P305+P351+P338, P310, P321, P330, P332+P313, P362, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • (+)-(3R,5S)-fluvastatin (-)-fluvastatin (3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
    (3R,5S)-fluvastatin (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
    (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid (3R,5S,6E)-rel-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid (3R,5S,E)-7-(3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid
    (E)-(3R,5S)-7-[3-(4-Fluoro-phenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxy-hept-6-enoic acid (E,3R,5S)-7-[3-(4-fluorophenyl)-1-isopropyl-indol-2-yl]-3,5-dihydroxy-hept-6-enoic acid (E,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
    6-Heptenoic acid, 7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)- 3,5-dihydroxy-, (3R,5S,6E)-rel- 6-Heptenoic acid, 7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)- 3,5-dihydroxy-, (R*,S*-(E))-(+-)- 6-Heptenoic acid, 7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-, (R*,S*-(E))-(+-)-
    6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, (3R,5S,6E)- 7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoate 93957-54-1
    957F541 ACT03305 API0002749
    BDBM86704 BRD-K66296774-001-02-0 C24H26FNO4
    CAS-93957-54-1 CAS_93957-54-1 CCG-213323
    CHEBI:38565 CHEBI:93160 CPD001453708
    CS-1226 Canef Cranoc
    DL-108 DSSTox_CID_636 DSSTox_GSID_20636
    DSSTox_RID_75707 DTXSID2020636 EN300-51915
    FJLGEFLZQAZZCD-MCBHFWOFSA-N Fluvastatin & Primycin Fluvastatin [INN:BAN]
    Fluvastatin sodium L1483; GTPL2951 HMS2089P06
    HMS3259J15 HY-14664 LS-7404
    Lescol NC00659 NCGC00256490-01
    NSC-758896 NSC758896 Pharmakon1600-01504911
    Prestwick2_000859 PubChem10727 Q417942
    SAM002548940 SCHEMBL2846 SCHEMBL556754
    SR-05000001489-1 Tox21_302765 UNII-4L066368AS component FJLGEFLZQAZZCD-MCBHFWOFSA-N
    W-5176 XU 62320 XU-62320
    ZINC1886617 fluvastatin

    CAS Number 155229-75-7, 93957-54-1
    PubChem Compound 446155
    ChEBI 38561
    PharmGKB PA449688