D0953 | glycyrrhetinic acid
D
D03AX10 Enoxolone
[D03AX] Other cicatrizants
[D03A] CICATRIZANTS
[D03] PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
[D] Dermatological drugs
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 40.10±9.34 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | human | HepG2 | MMP assay | Negative | IC50 | 163 | ||
| MEMBRANE POTENTIAL | 15.55±2.52 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Warning |
Aggregated GHS information provided by 40 companies from 1 notifications to the ECHA C&L Inventory. H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P301+P312, P330, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Warning |
Aggregated GHS information provided by 67 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 21 of 67 companies. For more detailed information, please visit ECHA C&L website Of the 3 notification(s) provided by 46 of 67 companies with hazard statement code(s): H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H319 (97.83%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 308mg/kg (308mg/kg) | Drugs in Japan Vol. -, Pg. 319, 1990. | |
| mouse | LD50 | subcutaneous | 518mg/kg (518mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 5, Pg. 98, 1963. | |
| mouse | LD50 | intravenous | 56mg/kg (56mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02067, | |
| (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid | (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-2,4a,6a,6b,9,9,12a-heptamethyl-10-oxidanyl-13-oxidanylidene-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid | (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid |
| (3?)-3-Hydroxy-11-oxoolean-12-en-30-oic acid | (3alpha,5xi,8alpha,9xi,17alpha,18xi)-3-hydroxy-11-oxoolean-12-en-29-oic acid | (3beta)-3-hydroxy-11-oxoolean-12-en-30-oic acid |
| (3beta,20beta)-3-Hydroxy-11-oxo-olean-12-en-29-oic acid | (3beta,5beta,14beta)-3-Hydroxy-11-Oxoolean-12-En-29-Oic Acid | (5S,8S,15S,18S,1R,2R,10R,14R,20R)-18-hydroxy-1,2,5,8,15,19,19-heptamethyl-13-o xopentacyclo[12.8.0.0<2,11>.0<5,10>.0<15,20>]docos-11-ene-8-carboxylic acid |
| 130100-EP2269977A2 | 130100-EP2295411A1 | 1449-05-4 |
| 18 beta-Glycyrrhetintic Acid | 18-beta-Glycyrrhetic acid | 18-beta-Glycyrrhetinic acid |
| 18-beta-Glycyrrhetinic acid, 98+% | 18b-Glycyrrhetic acid | 18beta-Glycyrrhetic acid |
| 18beta-Glycyrrhetinic acid | 18beta-Glycyrrhetinic acid | 18beta-Glycyrrhetinic acid, 97% |
| 18beta-Glycyrrhetinic acid, purum, >=97.0% (T) | 18|A-Glycyrrhetinic acid | 3-Glycyrrhetinic acid |
| 3-beta-Hydroxy-11-oxoolean-12-en-30-oic acid | 3?-Hydroxy-11-oxo-18?,20?-olean-12-en-29-oic acid; | 3beta-Hydroxy-11-oxo-18beta,20beta-olean-12-en-29-oic acid |
| 3beta-Hydroxy-11-oxoolean-12-en-30-oic acid | 3beta-hydroxy-11-oxoolean-12-en-29-oic acid | 4-10-00-03775 (Beilstein Handbook Reference) |
| 471-53-4 | 471G534 | A827163 |
| AC-1925 | AC-8906 | AKOS015960428 |
| AKOS016036757 | API0002854 | Arthrodont |
| BDBM50233538 | BRD-K96137854-001-17-1 | BRN 2229654 |
| Biosone | C02283 | C30H46O4 |
| CAS-471-53-4 | CBW | CCG-208506 |
| CCRIS 3962 | CHEBI: 30853 | CHEBI:30853 |
| CHEMBL230006 | CS-W020624 | D00156 |
| DB13089 | DSSTox_CID_669 | DSSTox_GSID_20669 |
| DSSTox_RID_75722 | DTXSID9020669 | EINECS 207-444-6 |
| Enoloxone | Enoxolona | Enoxolona [INN-Spanish] |
| Enoxolone | Enoxolone (Glycyrrhetin) | Enoxolone (Glycyrrhetinic acid) |
| Enoxolone (INN) | Enoxolone [INN:BAN:DCF] | Enoxolone, European Pharmacopoeia (EP) Reference Standard |
| Enoxolone, Glycyrrhetinic acid | Enoxolonum | Enoxolonum [INN-Latin] |
| FT-0082445 | G0149 | GLYCYRRHETINIC ACID |
| GM-1658 | Glyciram | Glycyrrhetic acid |
| Glycyrrhetin | Glycyrrhetinate | Glycyrrhetinic acid (JAN) |
| Glycyrrhetinic acid [JAN] | HMDB: 0011628 | HMS2233P23 |
| HY-N0180 | Hidermart (TN) | Jintan |
| KS-1262 | LMPR0106150014 | LS-7417 |
| MCULE-4676598997 | MFCD00003706 | MLS000028748 |
| MLS001146949 | MLS002207101 | NCGC00017244-03 |
| NCGC00017244-04 | NCGC00017244-06 | NCGC00142473-03 |
| NCGC00181115-01 | NCGC00258353-01 | NSC 35347 |
| NSC-35347 | NSC-35350 | Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3beta,20beta)- |
| Olean-12-en-30-oic acid, 3-beta-hydroxy-11-oxo- | Olean-12-en-30-oic acid, 3beta-hydroxy-11-oxo- | Olean-12-en-30-oic acid, 3beta-hydroxy-11-oxo- (8CI) |
| Opera_ID_1048 | P540XA09DR | Q-201057 |
| Q5948038 | Rhetinic Acid | S00284 |
| SBB006496 | SCHEMBL18540 | SMR000058239 |
| SR-01000721867 | SR-01000721867-3 | SR-01000721867-4 |
| SR-01000721867-5 | SR-01000721867-6 | ST056310 |
| ST24038257 | STX-352 | Tox21_110804 |
| Tox21_112726 | Tox21_200799 | UNII-P540XA09DR |
| Uralenic acid | ZINC19203131 | alpha-Glycyrrhetinic acid |
| enoxolone | s2296 |