Compound
D0954 | gramicidin
R
R02AB30 Gramicidin
[R02AB] Antibiotics
[R02A] THROAT PREPARATIONS
[R02] THROAT PREPARATIONS
[R] Respiratory system
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| TRANSPORT OF CHARGE BUT NOT PROTONS | affect | 201 | ||||||
| MEMBRANE POTENTIAL | 0.51±0.42 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 0.04 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 0.20±0.21 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 20800ug/kg (20.8mg/kg) | Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. Vol. 6, Pg. 285, 1957. | |
| 1405-97-6 | 5IE62321P4 | AKOS026750031 |
| GRAMICIDIN | Gramicidin [USP:INN:BAN] | Gramicidina |
| Gramicidine | Gramicidinum | HCO-Val-Gly-D-Leu-Ala-D-Val-Val-D-Val-[Trp-D-Leu]3-Trp-NH2-CH2CH2OH; |
| NSC183503 | SCHEMBL163104 | UNII-5IE62321P4 |
| ZWCXYZRRTRDGQE-SORVKSEFSA-N | garamicidin D |