D0956 | heptachlor
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 39.40±17.92 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 31.62 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | rat | hepatocytes | MMP assay | Negative | IC50 | 163 | ||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
   |
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H311: Toxic in contact with skin [Danger Acute toxicity, dermal] H351: Suspected of causing cancer [Warning Carcinogenicity] H373 **: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P201, P202, P260, P264, P270, P273, P280, P281, P301+P310, P302+P352, P308+P313, P312, P314, P321, P322, P330, P361, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
Aggregated GHS information provided by 45 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H300 (93.33%): Fatal if swallowed [Danger Acute toxicity, oral] H310 (93.33%): Fatal in contact with skin [Danger Acute toxicity, dermal] H351 (100%): Suspected of causing cancer [Warning Carcinogenicity] H373 (100%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P201, P202, P260, P262, P264, P270, P273, P280, P281, P301+P310, P302+P350, P308+P313, P310, P314, P321, P322, P330, P361, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H311: Toxic in contact with skin [Danger Acute toxicity, dermal] H351: Suspected of causing cancer [Warning Carcinogenicity] H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P201, P202, P260, P264, P270, P273, P280, P281, P301+P310, P302+P352, P308+P313, P312, P314, P321, P322, P330, P361, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H310: Fatal in contact with skin [Danger Acute toxicity, dermal] H351: Suspected of causing cancer [Warning Carcinogenicity] H360: May damage fertility or the unborn child [Danger Reproductive toxicity] H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] |
P201, P202, P260, P262, P264, P270, P280, P281, P301+P310, P302+P350, P307+P311, P308+P313, P310, P314, P321, P322, P330, P361, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mammal (species unspecified) | LD50 | unreported | 60mg/kg (60mg/kg) | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 59, 1971. | |
| rat | LD50 | intraperitoneal | 27mg/kg (27mg/kg) | Food and Cosmetics Toxicology. Vol. 11, Pg. 63, 1973. | |
| guinea pig | LDLo | skin | 1gm/kg (1000mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 2(5), Pg. 15, 1958. | |
| mouse | LD50 | intraperitoneal | 130mg/kg (130mg/kg) | Soviet Genetics. English translation of GNKAA5. Vol. 2, Pg. 80, 1966. | |
| guinea pig | LD50 | oral | 116mg/kg (116mg/kg) | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 576, 1966. | |
| mammal (species unspecified) | LCLo | inhalation | 200mg/m3/4H (200mg/m3) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 2(5), Pg. 15, 1958. | |
| rat | LD50 | oral | 40mg/kg (40mg/kg) | Pharmaceutical Journal. Vol. 185, Pg. 361, 1960. | |
| cat | LCLo | inhalation | 150mg/m3/4H (150mg/m3) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 71, 1982. | |
| rat | LD50 | skin | 119mg/kg (119mg/kg) | Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 12, 1978. | |
| mouse | LDLo | intravenous | 20mg/kg (20mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 107, Pg. 266, 1953. | |
| mouse | LD50 | oral | 68mg/kg (68mg/kg) | Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 12, 1978. | |
| rabbit | LD50 | skin | 500mg/kg (500mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 2(5), Pg. 15, 1958. | |
| hamster | LD50 | oral | 100mg/kg (100mg/kg) | European Journal of Toxicology and Environmental Hygiene. Vol. 7, Pg. 159, 1974. | |
| cat | LDLo | oral | 50mg/kg (50mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 2(5), Pg. 15, 1958. | |
| mouse | LD50 | intracrebral | 12mg/kg (12mg/kg) | behavioral: convulsions or effect on seizure threshold | Toxicology Letters. Vol. 60, Pg. 289, 1992. |
| (4S,7S)-1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-1H-4,7-methanoindene | 1(3a),4,5,6,7,8,8-Heptachloro-3a(1),4,7,7a-tetrahydro-4,7-methanoindene | 1(3a),5,6,7,8,8-Heptachloro-3a(1),4,7,7a-tetrahydro-4,7-methanoindene |
| 1,4,5,6,7,10,10-Heptachloro-4,7,8,9-tetrahydro-4,7-endo-methyleneindene | 1,4,5,6,7,10,10-Heptachloro-4,7,8,9-tetrahydro-4,7-endomethyleneindene | 1,4,5,6,7,10,10-Heptachloro-4,7,8,9-tetrahydro-4,7-methyleneindene |
| 1,4,5,6,7,10,10-hept achloro-4,7,8,9-tetrahydro-4,7-methyleneindene | 1,4,5,6,7,8,8-Eptacloro-3a,4,7,7a-tetraidro-4,7-endo-metano-indene | 1,4,5,6,7,8,8-Eptacloro-3a,4,7,7a-tetraidro-4,7-endo-metano-indene [Italian] |
| 1,4,5,6,7,8,8-Heptachloor-3a,4,7,7a-tetrahydro-4,7-endo-methano-indeen | 1,4,5,6,7,8,8-Heptachloor-3a,4,7,7a-tetrahydro-4,7-endo-methano-indeen [Dutch] | 1,4,5,6,7,8,8-Heptachlor-3a,4,7,7,7a-tetrahydro-4,7-endo-methano-inden |
| 1,4,5,6,7,8,8-Heptachlor-3a,4,7,7,7a-tetrahydro-4,7-endo-methano-inden [German] | 1,4,5,6,7,8,8-Heptachloro-3a,4,7,7,7a-tetrahydro-4,7-methylene indene | 1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-endo-methanoindene |
| 1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-endomethanoindene | 1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene | 1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindene |
| 1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanol-1H-indene | 1,4,5,6,7,8,8-Heptachlorotetrahydro-4,7-methanoindene | 1,4,5,6,7,8,8-h eptachloro-3a,4,7,7a-tetrahydro-4,7-endomethanoindene |
| 1,4,5,6,7,8,8-heptachloro-3a,4,7,7,7a-tetrahydro-4,7-methyleneindene | 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-1H-4,7-methanoindene | 1,4,5,6,7,8,8a-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindane |
| 1,4,5,6,7,8,8a-heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindene | 1,5,6,7,10,10-Heptachloro-4,7,8,9-tetrahydro-4,7-endo-methyleneindene | 1,5,6,7,10,10-Heptachloro-4,7,8,9-tetrahydro-4,7-methyleneindene |
| 1,5,6,7,8,8-Eptacloro-3a,4,7,7a-tetraidro-4,7-endo-metano-indene | 1,5,6,7,8,8-Heptachloor-3a,4,7,7a-tetrahydro-4,7-endo-methano-indeen | 1,5,6,7,8,8-Heptachlor-3a,4,7,7,7a-tetrahydro-4,7-endo-methano-inden |
| 1,5,6,7,8,8-Heptachloro-3a,4,7,7,7a-tetrahydro-4,7-methylene indene | 1,5,6,7,8,8-Heptachloro-3a,4,7,7a- tetrahydro-4,7-methanoindene | 1,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-endo-methanoindene |
| 1,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindene | 1,5,7,8,9,10,10-heptachlorotricyclo[5.2.1.0(2,6)]deca-3,8-diene | 1H-1,4,5, 6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindene |
| 1H-1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindene | 1H-1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-4-methanoindene | 3,4,5,6,7,8,8a-Heptachlorodicyclopentadiene |
| 3,5,6,7,8,8-Heptachlorodicyclopentadiene | 3-Chlorochlordene | 3a,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindene |
| 4, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro- | 4,7-Methano-1H-indene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro- | 4,7-Methanoindene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro- |
| 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-3-methyl-4,7-Methano-1H-ind ene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-6,9-methano-2,4,3-benzodioxathiepin | 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-3-methyl-4,7-Methano-1H-indene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-6,9-methano-2,4,3-benzodioxathiepin; | 76-44-8 |
| AI3-15152 | Aahepta | Agroceres |
| Arbinex 30TN | BDBM50410521 | BSPBio_002509 |
| Basaklor | C14185 | CAS-76-44-8 |
| CCG-39341 | CCRIS 324 | CHEBI:34785 |
| CHEMBL194400 | Caswell No. 474 | DSSTox_CID_679 |
| DSSTox_GSID_20679 | DSSTox_RID_75727 | DTXSID3020679 |
| Dicyclopentadiene, 3,4,5,6,7,8,8a-heptachloro- | Dicyclopentadiene,4,5,6,7,8,8a-heptachloro- | DivK1c_006686 |
| Drinox H-34 | E 3314 | EINECS 200-962-3 |
| ENT 15,152 | EPA Pesticide Chemical Code 044801 | Eptacloro |
| Eptacloro [Italian] | FRCCEHPWNOQAEU-UHFFFAOYSA-N | GPKh |
| Gold Crest H-60, Termide | H-34 | H-60 |
| HSDB 554 | Hepta | Heptachloor |
| Heptachloor [Dutch] | Heptachlor (technical grade) | Heptachlor [BSI:ISO] |
| Heptachlor and metabolites | Heptachlorane | Heptachlore |
| Heptachlore [French] | Heptachlore [ISO-French] | Heptachlorotetrahydro-4,7-methanoindene |
| Heptagran | Heptagranox | Heptamak |
| Heptamul | Heptasol | Heptox |
| Indene, 1,4,5,6,7,8,8-heptachloro-3alpha,4,7,7alpha-tetrahydro-4,7-methano- | KBio1_001630 | KBio2_002497 |
| KBio2_005065 | KBio2_007633 | KBio3_002009 |
| KBioGR_001229 | KBioSS_002505 | LS-1694 |
| Latka 104 | Latka 104 [Czech] | MLS002454407 |
| NCGC00091514-01 | NCGC00094549-01 | NCGC00094549-02 |
| NCGC00094549-03 | NCGC00094549-04 | NCGC00094549-05 |
| NCGC00254523-01 | NCGC00259460-01 | NCI-C00180 |
| NSC 8930 | NSC-8930 | NSC8930 |
| OMS 193 | Q417891 | RCRA waste no. P059 |
| Rcra waste number P059 | Rhodiachlor | SCHEMBL65124 |
| SMR001372010 | SPBio_001822 | SPECTRUM330078 |
| Soleptax | SpecPlus_000590 | Spectrum2_001891 |
| Spectrum3_000865 | Spectrum4_000705 | Spectrum5_002052 |
| Spectrum_001951 | Technical heptachlor | Tetrahydro |
| Tox21_201911 | Tox21_300534 | Velsicol 104 |
| Velsicol heptachlor | WLN: L C555 A DU IUTJ AG AG BG FG HG IG JG | alpha-Dicyclopentadiene, 3,4,5,6,7,8,8A-heptachloro- |
| hepta klor | heptachlor | heptaklor |