D0961 | indoxacarb
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 12.73±3.65 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 15.27 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 34.42±5.58 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Danger |
Aggregated GHS information provided by 208 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 3 of 208 companies. For more detailed information, please visit ECHA C&L website Of the 5 notification(s) provided by 205 of 208 companies with hazard statement code(s): H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin] H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation] H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P260, P261, P264, P270, P271, P272, P273, P280, P301+P310, P302+P352, P304+P312, P304+P340, P312, P314, P321, P330, P333+P313, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H332: Harmful if inhaled [Warning Acute toxicity, inhalation] H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P260, P261, P264, P270, P271, P272, P273, P280, P301+P310, P302+P352, P304+P312, P304+P340, P312, P314, P321, P330, P333+P313, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Danger |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure Narcotic effects] H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P260, P261, P264, P270, P271, P272, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P307+P311, P312, P314, P321, P330, P333+P313, P337+P313, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| (4aS)-indoxacarb | (S)-Indoxacarb | (S)-methyl 7-chloro-2-(methoxycarbonyl(4-(trifluoromethoxy)phenyl)carbamoyl)-2,3,4a,5-tetrahydroindeno[1,2-e][1,3,4]oxadiazine-4a-carboxylate |
| 173584-44-6 | 174060-41-4 | 31414-EP2274983A1 |
| 31414-EP2305662A1 | 31414-EP2308857A1 | 31414-EP2308858A1 |
| 31414-EP2311816A1 | 31414-EP2311817A1 | 52H0D26MWR |
| AS-35129 | Advion | Avatar |
| Avaunt | Avent | C18569 |
| C22H17ClF3N3O7 | CAS-173584-44-6 | CHEBI:38630 |
| CHEMBL197676 | D06316 | DPX-KN 128 |
| DPX-MP 062-381 | DSSTox_CID_12690 | DSSTox_GSID_32690 |
| DSSTox_RID_79034 | DTXSID1032690 | FT-0631195 |
| HSDB 7280 | Indeno(1,2-e)(1,3,4)oxadiazine-4a(3H)-carboxylic acid, 7-chloro-2,5-dihydro-2-(((methoxycarbonyl)(4-(trifluoromethoxy)phenyl)amino)carbonyl)-, methyl ester, (4aS)- | Indoxacarb |
| Indoxacarb (JAN) | Indoxacarb [ISO] | Indoxacarb, PESTANAL(R), analytical standard |
| LS-81841 | M576 | Methyl (S)-7chloro-2,5-dihydro-2-(((methoxycarbonyl)(4-(trifluoromethoxy)phenyl)amino)carbonylindeno(1,2-e)(1,3,4)oxadiazine-4a(3H)-carboxylate |
| NCGC00164264-02 | NCGC00164264-03 | NCGC00254629-01 |
| Pesticide3_Indoxacarb_C22H17ClF3N3O7_Methyl (4aS)-7-chloro-2-{(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]carbamoyl}-2,5-dihydroindeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate; | Provaunt | Q421469 |
| SCHEMBL22073 | Steward | Tox21_300723 |
| UNII-52H0D26MWR | UNII-PKL1F8Y0FV component VBCVPMMZEGZULK-NRFANRHFSA-N | ZINC28527855 |
| methyl (4aS)-7-chloro-2-[methoxycarbonyl-[4-(trifluoromethoxy)phenyl]carbamoyl]-3,5-dihydroindeno[1,2-e][1,3,4]oxadiazine-4a-carboxylate | methyl (4aS)-7-chloro-2-{(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]carbamoyl}-2,5-dihydroindeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate |