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Drug

D0967 | isoxicam

Molecular Formula C14H13N3O5S
Molecular Weight 335.34
Structure
State solid

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 5.18±2.90 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 2.75 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 4.92±0.80 rat hepatocytes MMP assay decrease IC50 163

Organism Test type Route Dose (normalized dose) Effect Source
rat LD50 oral > 5gm/kg (5000mg/kg) Agents and Actions, A Swiss Journal of Pharmacology. Vol. 7, Pg. 481, 1977.


  • (4-hydroxy-2-methyl-1,1-dioxobenzo[e]1,2-thiazin-3-yl)-N-(5-methylisoxazol-3-y l)carboxamide 2482AH 2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-(5-methyl-3-isoxazolyl)-, 1,1-dioxide
    3-{hydroxy[(5-methyl-1,2-oxazol-3-yl)amino]methylidene}-2-methyl-2,3-dihydro-4H-1,2-benzothiazin-4-one 1,1-dioxide 34552-84-6 4-Hydroxy-2-methyl-N-(5-methyl-3-isoxazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
    4-Hydroxy-2-methyl-N-(5-methyl-3-isoxazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide 4-hydroxy-2-methyl-N-(5-methyl-1,2-oxazol-3-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide 4-hydroxy-2-methyl-N-(5-methyl-3-isoxazolyl)-2H- 1,2-benzothiazine-3-carboxamide-1,1-dioxide
    4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide 8XU734C4NG AB00052335_13
    AB00052335_14 ACM34552846 AKOS005539580
    AKOS026749856 API0007739 BDBM50248151
    BPBio1_000185 BRN 0577221 BSPBio_000167
    BSPBio_003120 C14H13N3O5S CAS-34552-84-6
    CCG-40307 CHEBI:76163 CHEMBL1898455
    CHEMBL53292 CS-4726 CTK6C5653
    D04639 DB08942 DSSTox_CID_25462
    DSSTox_GSID_45462 DSSTox_RID_80893 DTXSID0045462
    DivK1c_000661 EINECS 252-084-5 FT-0725584
    HMS1568I09 HMS1922M07 HMS2092P16
    HMS2095I09 HMS2232A13 HMS3373J12
    HMS3712I09 HMS502B03 HY-B1130
    IDI1_000661 Isoxicam (USAN/INN) Isoxicam [USAN:BAN:INN]
    Isoxicam [USAN:INN:BAN] Isoxicam, analytical standard Isoxicamo
    Isoxicamo [INN-Spanish] Isoxicamum Isoxicamum [INN-Latin]
    J-019644 KBio1_000661 KBio2_002085
    KBio2_004653 KBio2_007221 KBio3_002620
    KBioGR_000725 KBioSS_002085 KS-1364
    LS-40540 MCULE-1659746677 MFCD00079374
    MLS000069554 Maxicam Maxicam (TN)
    N-(5-methyl-3-isoxazolyl)-4-hydroxy-2-methyl-2H-1,2-benzthiazine-3-carboxamide 1,1-dioxide; NCGC00016829-01 NCGC00016829-02
    NCGC00016829-03 NCGC00016829-04 NCGC00016829-05
    NCGC00016829-06 NCGC00016829-09 NCGC00023881-03
    NCGC00023881-04 NINDS_000661 NSC-758436
    NSC758436 Pacyl (antiinflammatory) Pharmakon1600-01503242
    Prestwick0_000044 Prestwick1_000044 Prestwick2_000044
    Prestwick3_000044 Prestwick_505 Q22075801
    SBI-0051800.P002 SCHEMBL1477990 SCHEMBL25947
    SMP1_000071 SMR000058828 SPBio_000903
    SPBio_002088 SPECTRUM1503242 SR-01000003112
    SR-01000003112-2 SR-01000003112-3 ST51015023
    STK603272 SW220080-1 Spectrum2_000862
    Spectrum3_001580 Spectrum4_000183 Spectrum5_001253
    Spectrum_001605 Tox21_110634 Tox21_110634_1
    UNII-8XU734C4NG W 8495 W-8495
    YYUAYBYLJSNDCX-UHFFFAOYSA-N ZINC13130154 ZINC49538599
    isoxicam

    DrugBank Name isoxicam
    DrugBank DB08942
    CAS Number 34552-84-6
    PubChem Compound 54677972
    KEGG Drug D04639
    ChEBI 76163