D0977 | lercanidipine hydrochloride
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 6.53±0.53 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 8.69 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 27.48±0.00 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Danger |
Aggregated GHS information provided by 49 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H301 (87.76%): Toxic if swallowed [Danger Acute toxicity, oral] H302 (12.24%): Harmful if swallowed [Warning Acute toxicity, oral] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P301+P310, P301+P312, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Warning |
Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory. H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P301+P312, P330, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester hydrochloride | 100427-27-8 | 132866-11-6 |
| 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O5-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] ester O3-methyl ester hydrochloride | 2-((3,3-diphenylpropyl)methylamino)-1,1-dimethylethyl methyl (4RS)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate monohydrochloride | 3,5-Pyridinedicarboxylic acid, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(3,3-diphenylpropyl)methylamino)-1,1-dimethylethyl methyl ester, monohydrochloride |
| 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-((3,3-diphenylpropyl)methylamino)-1,1-dimethylethyl methyl ester, monohydrochloride | 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, hydrochloride (1:1) | 3-(1-((3,3-Diphenylpropyl);(methyl);amino);-2-methylpropan-2-yl) |
| 3-(1-((3,3-diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride | 5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride | 5-methyl 2,6-dimethyl-4-(3-nitrophenyl);-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride |
| 866L116 | A806509 | AC-1420 |
| AK550821 | AKOS015846519 | AS-13358 |
| BCP11375 | C36H42ClN3O6 | CAS-132866-11-6 |
| CCG-221448 | CHEBI:31771 | CHEMBL2106419 |
| CS-2831 | Cardiovasc | Cardiovasc (TN) |
| Carmen | Corifeo | D01849 |
| DB-042142 | DSSTox_CID_26665 | DSSTox_GSID_46665 |
| DSSTox_RID_81807 | DTXSID3046665 | EBD51404 |
| FT-0627794 | FT-0631144 | G00009-Watson-Int |
| H990 | HY-B0612A | J-006235 |
| J-006236 | J-521641 | KS-000002DP |
| L0282 | LCP-Lerc | LP00144 |
| Lercadip | Lercan | Lercanidipine (hydrochloride) |
| Lercanidipine HCl | Lercanidipine hydrochloride | Lercanidipine hydrochloride (1:x) |
| Lercanidipine hydrochloride (JAN/USAN) | Lercanidipine hydrochloride [USAN] | Lercanidipine hydrochloride hemihydrate |
| Lercanidipine hydrochloride, >=98% (HPLC) | Lercapin | Lercaton |
| Lerdip | Lerkamen | Lerzam |
| MCULE-2712241399 | Masnidipine (hydrochloride) | Masnidipine hydrochloride |
| NCGC00167492-01 | NCGC00167492-03 | NCGC00260829-01 |
| O5-[1-[3,3-diphenylpropyl(methyl)amino]-2-methyl-propan-2-yl] O3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride; | Q27285537 | R 75 |
| Rec-15/2375 | Renovia | SCHEMBL217099 |
| TJN-324 | Tox21_112493 | Tox21_112493_1 |
| Tox21_500144 | Vasodip | WMFYOYKPJLRMJI-UHFFFAOYSA-N |
| Zandip | Zanedip | Zanicor |
| Zanidip | Zanidip (hydrochloride) | Zanidip hydrochloride |
| lercanidipine-hydrochloride | s4597 |