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2021 MitoTox | (CC BY-NC 4.0)
Drug

D0978 | lestaurtinib

Molecular Formula C26H21N3O4
Molecular Weight 439.5
Structure
State solid

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 4.80±0.97 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 5.62 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 12.76±2.67 rat hepatocytes MMP assay decrease IC50 163


  • (15S,16S,18R)-16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8,10,12,20,22,24-nonaen-3-one (5R,7S,8S)-7-hydroxy-7-(hydroxymethyl)-8-methyl-5,6,7,8,13,14-hexahydro-15H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-15-one (9S,10S,12R)-10-Hydroxy-10-(hydroxymethyl)-9-methyl-2,3,9,10,11,12-hexahydro-9,12-epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocin-1-one
    (9S,10S,12R)-2,3,9,10,11,12-Hexahyd ro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epo xy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1, 6]benzodiazocin-1-one (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one 111358-88-4
    16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one 4otg 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-, (9S,10S,12R)-
    9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-, (9S-(9alpha,10beta,12alpha))- 9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-, (9S,10S,12R)- A 1544750
    A-154475 A-154475.0 A-1544750
    AC-5243 AKOS024457603 AM81228
    BCP06977 BDBM50308060 BIL2000
    BRD-K23192422-001-01-1 C26H21N3O4 CAS-111358-88-4
    CEP 701 CEP-701 CEP-701|||KT-5555|||(5S,6S,8R)-6-Hydroxy-6-(hydroxymethyl)-5-methyl-7,8,14,15-tetrahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-13(6H)-one;
    CHEBI:91471 CHEMBL603469 CS-0004336
    CTK8F0849 D04696 DB06469
    DO989GC5D1 DSSTox_CID_26778 DSSTox_GSID_46778
    DSSTox_RID_81897 DTXSID5046778 FT-0670762
    GTPL5672 HY-50867 J-002567
    KT 5555 KT-555 KT-5555
    KT5555 Lestaurtinib Lestaurtinib (USAN/INN)
    Lestaurtinib [USAN:INN] MFCD12828858 NCGC00168772-01
    NCGC00168772-02 NCGC00168772-03 NCGC00168772-04
    Q6531771 RT-013568 SCHEMBL1649693
    SP 924 SP-924 SP924
    SPM-924 Tox21_112633 UIARLYUEJFELEN-LROUJFHJSA-N
    UNII-DO989GC5D1 V0246 ZINC3781738
    cc-713

    DrugBank Name lestaurtinib
    DrugBank DB06469
    CAS Number 111358-88-4
    PubChem Compound 126565
    KEGG Drug D04696