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Drug

D0980 | lornoxicam

Molecular Formula C13H10ClN3O4S2
Molecular Weight 371.8
Structure
State solid
Protein binding Lornoxicam is 99% bound to plasma proteins (almost exlusively to serum albumin).
Half life 3-5 hours
Absorption Lornoxicam is absorbed rapidly and almost completely from the GI tract (90-100%).

M

M01AC05 Lornoxicam


[M01AC] Oxicams


[M01A] ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS


[M01] ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS


[M] Musculoskeletal system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 9.44±1.09 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 6.15 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 3.30±2.52 rat hepatocytes MMP assay decrease IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 41 companies from 2 notifications to the ECHA C&L Inventory.


H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P264, P270, P301+P310, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rat LD50 oral 5730ug/kg (5.73mg/kg) Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 94, Pg. 61, 1989.


  • (3E)-6-chloro-3-[hydroxy(pyridin-2-ylamino)methylene]- 2-methyl-2,3-dihydro-4H-thieno[2,3-e][1,2] thiazin- 4 - one 1,1-dioxide (3Z)-6-chloranyl-2-methyl-1,1-bis(oxidanylidene)-3-[oxidanyl-(pyridin-2-ylamino)methylidene]thieno[2,3-e][1,2]thiazin-4-one (3Z)-6-chloro-3-[hydroxy-(2-pyridinylamino)methylidene]-2-methyl-1,1-dioxo-4-thieno[2,3-e]thiazinone
    (3e)-6-chloro-3-[hydroxyl(pyridin-2-ylamino)methylene]-2-methyl-2,3-dihydro-4h-thieno[2,3-e][1,2]thiazin-4-one 1,1-dioxide (6-chloro-4-hydroxy-2-methyl-1,1-dioxothiopheno[2,3-e]1,2-thiazin-3-yl)-N-(2-p yridyl)carboxamide 2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXAMIDE, 6-CHLORO-4-HYDROXY-2-METHYL-N-2-PYRIDINYL-, 1,1-DIOXIDE
    2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide 2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-,1,1-dioxide 2H-Thieno(3,2-e)-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide
    374L399 6-Chloro-4-hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-Dioxide 6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-Dioxide
    6-Chloro-4-hydroxy-2-methyl-N-2-pyridyl-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide 6-Chloro-4-hydroxy-2-methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide (Lornoxicam); 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-(pyridin-2-yl)-2H-1|E?-thieno[2,3-e][1,2]thiazine-3-carboxamide
    6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide 6-chloro-4-hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-2H-thieno[2,3-e]-1,2-thiazine-1,1-dioxide 6-chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide
    6-chloro-4-hydroxy-2-methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide 70374-39-9 A836864
    AB0012428 AB00876293_04 AB00876293_06
    AB07518 AB2000451 AC-4675
    AK468625 AKOS000281810 AKOS026750113
    ALBB-014101 ANW-42384 BCP04666
    BCP0726000036 BCP9000860 BDBM92331
    BRN 1039965 C13H10ClN3O4S2 CCG-213023
    CCRIS 8589 CHEBI:31783 CHEMBL1569487
    CHEMBL3188235 CLTX CS-2424
    CTK8B3366 Chlortenoxicam D01866
    DB06725 ER09126G7A FT-0630797
    HMS2231B07 HMS3264I20 HMS3655N13
    HN-10000 HY-B0367 KS-00000GI1
    KS-1080 L0239 LS-152550
    Lorcam Lorcam (TN) Lornoxicam
    Lornoxicam (JAN/USAN/INN) Lornoxicam (Xefo) Lornoxicam [USAN:INN:BAN]
    Lornoxicam, >=98% (HPLC) Lornoxicamum Lornoxicamum [INN-Latin]
    MFCD00866163 MLS001165721 MLS001304721
    MLS006010084 NCGC00246566-01 NCGC00346667-01
    NSC-759620 NSC759620 Pharmakon1600-01502302
    Q-101309 Q2734874 Ro 13-9297
    Ro-13-9297 Ro-139297 S-7774
    SBB056363 SCHEMBL1650239 SCHEMBL35101
    SCHEMBL35102 SMR000550483 SR-01000799148
    SR-01000799148-3 STL504715 SW220125-1
    Safem TS 110 TS-110
    TS110 Taigalor Telos
    UNII-ER09126G7A WLHQHAUOOXYABV-UHFFFAOYSA-N Xefo
    Xefocam ZINC100015491 ZINC49089868
    ZINC5318420 lornoxicam-xefo s2047

    DrugBank Name lornoxicam
    DrugBank DB06725
    CAS Number 70374-27-5, 70374-39-9
    PubChem Compound 54690031
    KEGG Drug D01866
    ChEBI 31783
    PharmGKB PA165958395