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Compound

D0985 | malotilate

Molecular Formula C12H16O4S2
Molecular Weight 288.4
Structure

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 14.96±1.99 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 39.81 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 23.92±29.35 rat hepatocytes MMP assay decrease IC50 163

Organism Test type Route Dose (normalized dose) Effect Source
hamster LD50 oral 2707mg/kg (2707mg/kg) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 387, 1978.
mouse LD50 intraperitoneal 1220mg/kg (1220mg/kg) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 387, 1978.
guinea pig LD50 oral 2101mg/kg (2101mg/kg) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 387, 1978.
hamster LD50 intraperitoneal 1533mg/kg (1533mg/kg) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 387, 1978.
mouse LD50 oral 3120mg/kg (3120mg/kg) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 387, 1978.
rabbit LD50 subcutaneous > 5gm/kg (5000mg/kg) behavioral: somnolence (general depressed activity) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 387, 1978.
mouse LD50 subcutaneous 1732mg/kg (1732mg/kg) Shenyang Yaoxueyuan Xuebao. Journal of Shenyang College of Pharmacy. Vol. 2, Pg. 269, 1985.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg) behavioral: somnolence (general depressed activity) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 387, 1978.
mouse LD50 intramuscular > 5gm/kg (5000mg/kg) behavioral: somnolence (general depressed activity) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 387, 1978.
rabbit LD50 intraperitoneal 656mg/kg (656mg/kg) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 387, 1978.
rat LD50 oral 2065mg/kg (2065mg/kg) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 387, 1978.
rat LD50 intraperitoneal 750mg/kg (750mg/kg) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 387, 1978.
mouse LD50 intravenous 729mg/kg (729mg/kg) Shenyang Yaoxueyuan Xuebao. Journal of Shenyang College of Pharmacy. Vol. 2, Pg. 269, 1985.
guinea pig LD50 intraperitoneal 1011mg/kg (1011mg/kg) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 387, 1978.
rabbit LD50 oral 706mg/kg (706mg/kg) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 387, 1978.
rat LD50 intramuscular > 2gm/kg (2000mg/kg) behavioral: somnolence (general depressed activity) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 387, 1978.


  • (1,3-Dithiol-2-ylidene)malonic Acid Diisopropyl Ester; 1,3-Dithiol-2-ylidenepropanedioic acid, bis(1-methylethyl) ester 59937-28-9
    937M289 AB0007968 AB01566806_01
    ABP000477 AK327287 AKOS025119303
    AS-11770 BCP01805 BCP9000892
    BRD-K97884852-001-02-1 Bis(1-methylethyl) 1,3-dithiol-2-ylidenepropanedioate C-18144
    C12H16O4S2 CAS-59937-28-9 CC-30142
    CHEBI:31798 CHEMBL1697754 CL-1500
    CS-1594 CTK8E7254 D01770
    DA-3857 DSSTox_CID_26463 DSSTox_GSID_46463
    DSSTox_RID_81637 DTXSID7046463 Diisopropyl (1,3-Dithiol-2-ylidene)malonate
    Diisopropyl 1,3-dithiol-2-ylidenemalonate Diisopropyl 1,3-dithiole-delta(sup 2,alpha)-malonate Diisopropyl 2-(1,3-dithiol-2-ylidene)malonate
    Diisopropyl-1,3-dithiol-2-ylidenemalonate EINECS 261-987-3 FT-0082404
    FT-0601567 HMS3654I08 HY-A0060
    KM0356 KS-00000XLR Kantec
    Kantec (TN) LS-88812 M2674
    MALONIC ACID, (1,3-DITHIOL-2-YLIDENE)-, DIISOPROPYL ESTER MLS006010037 Malotilate (JAN/USAN/INN)
    Malotilate [USAN:INN:JAN] Malotilate/ Malotilato
    Malotilato [INN-Spanish] Malotilatum Malotilatum [INN-Latin]
    NCGC00164588-01 NCGC00164588-02 NCGC00164588-03
    NKK 105 NKK-105 NKK105
    Propanedioic acid, 1,3-dithiol-2-ylidene-, bis(1-methylethyl) ester Q6744548 RV59PND975
    SC-13551 SCHEMBL635496 SMR002530051
    SW219173-1 TC-030563 Tox21 112214
    Tox21_112214 Tox21_112214_1 Tractal
    UNII-RV59PND975 VA11228 YPIQVCUJEKAZCP-UHFFFAOYSA-N
    ZINC1542902 dipropan-2-yl 2-(1,3-dithiol-2-ylidene)propanedioate malotilate
    s1137

    CAS Number 59937-28-9, 6164-81-4
    PubChem Compound 4006
    KEGG Drug D01770
    ChEBI 31798