Compound
D0990 | metanixin
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 25.98±2.11 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 21.82 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 21.03±1.37 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | oral | 645mg/kg (645mg/kg) | Therapie. Vol. 22, Pg. 157, 1967. | |
| mouse | LD50 | intravenous | 280mg/kg (280mg/kg) | Therapie. Vol. 22, Pg. 157, 1967. | |
| mouse | LD50 | intraperitoneal | 385mg/kg (385mg/kg) | Therapie. Vol. 22, Pg. 157, 1967. | |
| rat | LD50 | oral | 2300ug/kg (2.3mg/kg) | Therapie. Vol. 22, Pg. 157, 1967. | |
| 2-(2,6-Xylidino)nicotinic acid | 2-(2,6-Xylidino)nicotinsaeure | 2-[(2,6-dimethylphenyl)amino]pyridine-3-carboxylic Acid |
| 3-Pyridinecarboxylic acid, 2-((2,6-dimethylphenyl)amino)- | 3-Pyridinecarboxylic acid, 2-((2,6-dimethylphenyl)amino)- (9CI); | 4394-04-1 |
| AKOS009173650 | Acide nixylique | Acido nixilico |
| Acidum nixylicum | BRN 0482454 | CAS-4394-04-1 |
| CHEMBL2104706 | DSSTox_CID_25693 | DSSTox_GSID_45693 |
| DSSTox_RID_81065 | DTXSID3045693 | LS-96642 |
| Metanixin | Metanixin [INN] | Metanixine [French] |
| Metanixine [INN-French] | Metanixino | Metanixino [INN-Spanish] |
| Metanixino [Spanish] | Metanixinum | Metanixinum [INN-Latin] |
| Metanixinum [Latin] | NICOTINIC ACID, 2-(2,3-XYLIDINO)- | OWY6DMB1YX |
| Q27285895 | SCHEMBL2107737 | Tox21_110969 |
| UNII-OWY6DMB1YX | UP 74 | Z2677432404 |
| ZINC1694 |
| CAS Number | 4394-04-01 00:00:00 |
| PubChem Compound | 10466908 |