Drug
D1022 | nocodazole
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 3.53±1.63 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 2.18 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | rat | hepatocytes | MMP assay | Negative | IC50 | 163 | ||
| AUTOPHAGY | 1µM | overnight | HeLa cells | Cyto-ID Autophagy Detection dye and Autophagy compound library in a microplate-based assay | induce | >2 fold increase | 277 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Warning |
Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H341 (97.73%): Suspected of causing genetic defects [Warning Germ cell mutagenicity] H361 (97.73%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P201, P202, P281, P308+P313, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 39530ug/kg (39.53mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |
| (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamic acid methyl ester | 2-Benzimidazolecarbamic acid, 5-(2-thenoyl)-, methyl ester | 2-Benzimidazolecarbamic acid, 5-(2-thenoyl)-, methyl ester (8CI) |
| 2-Benzimidazolecarbamic acid, 5-(2-thienoyl)-, methyl ester | 2-Benzimidazolecarbamic acid, 5-(2-thienylcarbonyl)-, methyl ester | 2593AH |
| 31430-18-9 | 3ee2 | AB0109635 |
| AC-25615 | AK326024 | AKOS000538825 |
| AKOS015901529 | AM807900 | AOB6196 |
| API0003615 | BCBcMAP01_000161 | BCP07558 |
| BDBM97233 | BIDD:GT0494 | BN0389 |
| BPBio1_000066 | BRD-K12539581-001-06-2 | BRD-K12539581-001-14-6 |
| BSPBio_000060 | BSPBio_000982 | BSPBio_003235 |
| Bio1_000461 | Bio1_000950 | Bio1_001439 |
| Bio2_000331 | Bio2_000811 | C13719 |
| C14H11N3O3S | CAS-31430-18-9 | CBDivE_004971 |
| CBDivE_008428 | CCG-101240 | CCG-208075 |
| CHEBI:34892 | CHEMBL9514 | CP-0076 |
| CS-1893 | CTK8G1974 | Cambridge id 5175348 |
| Carbamic acid, (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-, methyl ester | Carbamic acid, (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-, methyl ester (9CI) | Carbamic acid, (5-(2-thienylcarbonyl)-1H-benzimidazole-2-yl)-, methyl ester |
| Carbamic acid, N-[5-(2-thenoyl)-1H-benzimidazol-2-yl]-, methyl ester | Carbamic acid, N-[6-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-, methyl ester | Carbamic acid, [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-, methyl ester |
| Carbamic acid, [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-, methyl ester (9CI) | ChemDiv1_000089 | D05197 |
| DB08313 | DSSTox_CID_11800 | DSSTox_GSID_31800 |
| DSSTox_RID_78890 | DTXSID9031800 | EINECS 250-626-5 |
| EU-0100733 | FT-0660415 | GP8428 |
| HMS1362B03 | HMS1568C22 | HMS1792B03 |
| HMS1922O09 | HMS1990B03 | HMS2094G13 |
| HMS2095C22 | HMS2235E18 | HMS3262C08 |
| HMS3267F03 | HMS3403B03 | HMS3412A10 |
| HMS3604E13 | HMS3656J06 | HMS3676A10 |
| HMS3712C22 | HMS587E01 | HY-13520 |
| IDI1_002086 | KBio2_000322 | KBio2_002890 |
| KBio2_005458 | KBio3_000643 | KBio3_000644 |
| KBio3_002735 | KBioGR_000322 | KBioGR_001360 |
| KBioSS_000322 | KS-00000XH0 | KYRVNWMVYQXFEU-UHFFFAOYSA-N |
| LP00733 | LS-1178 | Lopac-M-1404 |
| Lopac0_000733 | M 1404 | MCULE-3133043736 |
| MFCD00005588 | MLS000860046 | MLS001164242 |
| Methyl (5-(2-thienylcarbonyl))-1H-benzimidazole-2-ylcarbamate | Methyl (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)carbamate | Methyl 5-(2-thenoyl)-2-benzimidazolecarbamate |
| Methyl 5-(2-thienoyl)-2-benzimidazolecarbamate | Methyl N-(5-thenoyl-2-benzimidazolyl)carbamate | Methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate |
| Methyl [5-(2-thienylcarbonyl)-1H- benzimidazol-2-yl]carbamate | Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate | Methyl(5-(2-thienylcarbonyl))-1H-benzimidazole-2-yl carbamate |
| Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate | Methyl[5-(2-thienylcarbonyl)]-1H-benzimidazole-2-yl carbamate | N-(5-(2-Thenoyl)-2-benzimidazolyl)carbamic acid methyl ester |
| N-(5-(2-Thienoyl)-2-benzimidazolyl)carbamic acid methyl ester | N-[5-(2-Thenoyl)-2-benzimidazolyl]carbamic acid methyl ester | N-[5-(2-Thienoyl)-2-benzimidazolyl]carbamic acid methyl ester |
| N-[6-(2-thenoyl)-1H-benzimidazol-2-yl]carbamic acid methyl ester | N-[6-[oxo(thiophen-2-yl)methyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester; | NCGC00015647-01 |
| NCGC00015647-02 | NCGC00015647-03 | NCGC00015647-04 |
| NCGC00015647-05 | NCGC00015647-06 | NCGC00015647-07 |
| NCGC00015647-08 | NCGC00015647-09 | NCGC00015647-10 |
| NCGC00015647-11 | NCGC00015647-12 | NCGC00015647-13 |
| NCGC00015647-14 | NCGC00015647-15 | NCGC00015647-18 |
| NCGC00025058-01 | NCGC00025058-02 | NCGC00025058-03 |
| NCGC00025058-04 | NCGC00025058-05 | NCGC00025058-06 |
| NCGC00025058-07 | NCGC00025058-08 | NCGC00025058-09 |
| NCGC00025058-10 | NCGC00261418-01 | NCI60_001911 |
| NSC 238 159 | NSC 238159 | NSC-238159 |
| NSC-759882 | NSC238159 | NSC759882 |
| NZO | Nocidazole | Nococazole |
| Nocodazol | Nocodazol [INN-Spanish] | Nocodazole (USAN/INN) |
| Nocodazole [USAN:INN] | Nocodazole, 98% | Nocodazole, >=99% (TLC), powder |
| Nocodazolum | Nocodazolum [INN-Latin] | Oncodazole |
| Oprea1_483899 | Oprea1_741554 | Pharmakon1600-01503266 |
| Prestwick0_000100 | Prestwick1_000100 | Prestwick2_000100 |
| Prestwick3_000100 | Prestwick_359 | Probes1_000012 |
| Probes1_000176 | Probes2_000086 | Probes2_000148 |
| Q2506092 | QTL1_000062 | R 17,934 |
| R 17934 | R-17934 | R17,934 |
| R17934 | SB19455 | SBI-0050711.P002 |
| SC-21129 | SCHEMBL9477 | SH1WY3R615 |
| SMP2_000261 | SMR000326904 | SPBio_001999 |
| SPECTRUM1503266 | SR-01000075979 | SR-01000075979-1 |
| SR-01000075979-3 | SR-01000075979-6 | SR-01000075979-9 |
| ST078193 | STK832483 | SW102861-5 |
| Spectrum3_001768 | Spectrum4_001060 | Tocris-1228 |
| Tox21_110189 | Tox21_110189_1 | Tox21_500733 |
| UNII-SH1WY3R615 | UPCMLD-DP111 | UPCMLD-DP111:001 |
| W-202288 | ZINC56509 | [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid methyl ester |
| [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]carbonic acid, methyl ester | [5-(Thiophene-2-carbonyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester | [[5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]]carbamic acid methyl ester |
| carbamic acid, [6-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-, methyl ester | cid_4122 | methoxy-N-[6-(2-thienylcarbonyl)benzimidazol-2-yl]carboxamide |
| methyl (5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-yl)carbamate | methyl (6-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-yl)carbamate | methyl 6-(thien-2-ylcarbonyl)-1H-benzimidazol-2-ylcarbamate |
| methyl N-(6-thiophen-2-ylcarbonyl-1H-benzimidazol-2-yl)carbamate | methyl N-[5-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate | methyl [6-(thiophen-2-ylcarbonyl)-1H-benzimidazol-2-yl]carbamate |
| nocodazole | s2775 |