MITOTOX

Drug

D1024 | norelgestromin

Properties

Molecular Formula	C21H29NO2
Molecular Weight	327.5
Structure
State	solid

Therapeutic Classification Source: DrugBank

G03AA13 Norelgestromin and ethinylestradiol

[G03AA] Progestogens and estrogens, fixed combinations

[G03A] HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE

[G03] SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM

[G] Genitourinary system and reproductive hormones

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Species	Model	Method	Action	Positive criterion	Reference
MEMBRANE POTENTIAL	13.53±6.64	human	qHTS-HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	19.45	human	HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	13.37±12.30	rat	hepatocytes	MMP assay	decrease	IC50	163

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Danger	Aggregated GHS information provided by 19 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302 (89.47%): Harmful if swallowed [Warning Acute toxicity, oral] H312 (89.47%): Harmful in contact with skin [Warning Acute toxicity, dermal] H332 (89.47%): Harmful if inhaled [Warning Acute toxicity, inhalation] H351 (89.47%): Suspected of causing cancer [Warning Carcinogenicity] H360 (84.21%): May damage fertility or the unborn child [Danger Reproductive toxicity] H361 (10.53%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Danger

Aggregated GHS information provided by 19 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H302 (89.47%): Harmful if swallowed [Warning Acute toxicity, oral]

H312 (89.47%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H332 (89.47%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H351 (89.47%): Suspected of causing cancer [Warning Carcinogenicity]

H360 (84.21%): May damage fertility or the unborn child [Danger Reproductive toxicity]

H361 (10.53%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

Synonyms Source: PubChem

17-Deacetyl norgestimate;17-Deacylnorgestimate	17-Desacetyl Norgestimate	3046AH
53016-31-2	AKOS015917579	BDBM50103633
CAS-53016-31-2	CHEBI:135398	CHEMBL1200807
D05205	DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE);	DSSTox_CID_26788
DSSTox_GSID_46788	DSSTox_RID_81906	DTXSID9046788
Deacetylnorgestimate	Evra	HY-G0018
NCGC00168787-01	NCGC00485891-01	Norelgestromin
Norelgestromin (USAN/INN)	Norgestimate metabolite Norelgestromin	Ortho Evra
RWJ-10553	SCHEMBL3163347	Tox21_112647

External IDs

DrugBank Name	norelgestromin
DrugBank	DB06713
CAS Number	53016-31-2
PubChem Compound	9568628
KEGG Drug	D05205
ChEBI	135398