Compound
D1028 | o,p'-ddd
L
L01XX23 Mitotane
[L01XX] Other antineoplastic agents
[L01X] OTHER ANTINEOPLASTIC AGENTS
[L01] ANTINEOPLASTIC AGENTS
[L] Antineoplastic and immunomodulating agents
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 19.83±0.94 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 19.45 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 24.18±14.72 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Warning |
Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Reported as not meeting GHS hazard criteria by 3 of 44 companies. For more detailed information, please visit ECHA C&L website Of the 3 notification(s) provided by 41 of 44 companies with hazard statement code(s): H351 (100%): Suspected of causing cancer [Warning Carcinogenicity] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P201, P202, P281, P308+P313, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
 |
Danger |
H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure Narcotic effects] H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] |
P260, P261, P264, P270, P271, P304+P340, P307+P311, P312, P314, P321, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| (+-)-1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane | (2,4'-Dichlorodiphenyl)dichloroethane | (o,p')-DDD |
| (o,p)-DDD | 000M850 | 1,1-Dichloro-2,2-bis(2,4'-dichlorophenyl)ethane |
| 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane | 1,1-Dichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl)ethane | 1,2-bis(2,4'-dichlorophenyl)ethane |
| 1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane | 1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane for diagnostic uses (cancer investigation), >=98% (HPLC) | 1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane, analytical standard |
| 1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane, for diagnostic uses (cancer investigation), >=98% (HPLC); | 1-(o-Chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane | 1-Chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)benzene |
| 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene | 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene # | 1-[2,2-dichloro-1-(4-chlorophenyl)ethyl]-2-chlorobenzene |
| 1-chloro-4-[2,2-dichloro-1-(2-chlorophenyl)ethyl]benzene | 2,2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane | 2,4 -Dichlorodiphenyldichloroethane |
| 2,4 inverted exclamation marka-DDD | 2,4 inverted exclamation marka-DDD;o,p'-DDD | 2,4'-(2,2-dichloroethane-1,1-diyl)bis(chlorobenzene) |
| 2,4'-DDD 10 microg/mL in Cyclohexane | 2,4'-DDD 100 microg/mL in Cyclohexane | 2,4'-DDD 100 microg/mL in Methanol |
| 2,4'-DDD, PESTANAL(R), analytical standard | 2,4'-DDD, analytical standard | 2,4'-Ddd |
| 2,4'-Dichlorodiphenyldichloroethane | 2,4'-Dichlorophenyldichlorethane | 2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane |
| 2-(o-Chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloroethane | 53-19-0 | AB00052337-09 |
| AB00052337_10 | AB0010565 | AI3-07575 |
| AK546750 | AKOS006028802 | AS-11690 |
| BCP11663 | BRN 2056007 | BSPBio_002517 |
| Benzene, 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)- | Benzene, 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)-, (+-)- | Benzene, 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]- |
| C 3010 | C14H10Cl4 | CAS-53-19-0 |
| CB 313 | CB-313 | CB313 |
| CCG-40014 | CCRIS 4397 | CHEBI:6954 |
| CHEMBL1670 | CS-1500 | CTK8E2992 |
| Chloditan | Chlodithan | Chlodithane |
| D00420 | DB00648 | DDD, o,p'- |
| DDD-o,p' | DSSTox_CID_372 | DSSTox_GSID_20372 |
| DSSTox_RID_75548 | DTXSID9020372 | DivK1c_000703 |
| EINECS 200-166-6 | EN300-37268 | EU-0100251 |
| Ethane, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)- | Ethane, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)- (8CI) | Ethane, 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloro- |
| Ethane,1-dichloro- | Ethane,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)- | FT-0605518 |
| GTPL6957 | HMS1923K19 | HMS2091E07 |
| HMS2232C16 | HMS3260D04 | HMS3369H10 |
| HMS3655G06 | HMS3715H07 | HMS502D05 |
| HSDB 3240 | HY-13690 | IDI1_000703 |
| JWBOIMRXGHLCPP-UHFFFAOYSA-N | KBio1_000703 | KBio2_002505 |
| KBio2_005073 | KBio2_007641 | KBio3_002017 |
| KBioGR_001237 | KBioSS_002513 | Khloditan |
| Khlodithan | LP00251 | LS-185 |
| Lopac0_000251 | Lysodren | Lysodren (TN) |
| MCULE-2068358149 | MFCD00000850 | MLS001335899 |
| MLS001335900 | MLS002152914 | MLS002153233 |
| Mitotan | Mitotane (JAN/USP/INN) | Mitotane (Lsodren) |
| Mitotane (Lysodren) | Mitotane [USAN:INN:JAN] | Mitotane [USAN:USP:INN:BAN:JAN] |
| Mitotane(Lysodren) | Mitotane, >=98% (HPLC) | Mitotane, United States Pharmacopeia (USP) Reference Standard |
| Mitotano | Mitotano [INN-Spanish] | Mitotanum |
| Mitotanum [INN-Latin] | Mytotan | NCGC00015226-02 |
| NCGC00015226-03 | NCGC00015226-04 | NCGC00015226-05 |
| NCGC00015226-06 | NCGC00015226-07 | NCGC00015226-08 |
| NCGC00015226-09 | NCGC00015226-10 | NCGC00015226-11 |
| NCGC00015226-12 | NCGC00091374-01 | NCGC00091374-02 |
| NCGC00091374-03 | NCGC00091374-04 | NCGC00091374-05 |
| NCGC00091374-06 | NCGC00256452-01 | NCGC00260936-01 |
| NCI-C04933 | NCI60_003688 | NINDS_000703 |
| NSC 38721 | NSC-38721 | NSC-755849 |
| NSC38721 | NSC755849 | Opeprim |
| Pharmakon1600-00330082 | Prestwick_75 | PubChem14974 |
| Q417465 | SBI-0050239.P004 | SC-18530 |
| SCHEMBL4040 | SMR000326696 | SPBio_000792 |
| SPECTRUM330082 | SR-01000075751 | SR-01000075751-1 |
| SR-01000075751-3 | SR-01000075751-6 | ST51016017 |
| SW199619-3 | Spectrum2_000916 | Spectrum3_000869 |
| Spectrum4_000709 | Spectrum5_002060 | Spectrum_001959 |
| TR-018813 | Tox21_110103 | Tox21_110103_1 |
| Tox21_302804 | Tox21_500251 | W-5031 |
| WLN: GYGYR BG&R DG | Z425389592 | mitotane |
| o,p'-DDD | o,p'-DDD|||1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane|||Mitotane | o,p'-Dichlorodiphenyldichloroethane |
| o,p'-TDE | o,p-DDD | o,p-Tde |
| ortho,para-DDD | s1732 |