MITOTOX

Compound

D1037 | palmatine chloride hydrate

Properties

Molecular Formula	C21H24ClNO5
Molecular Weight	405.9
Structure

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Species	Model	Method	Action	Positive criterion	Reference
MEMBRANE POTENTIAL	22.74±5.23	human	qHTS-HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	12.59	human	HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	1.37±0.70	rat	hepatocytes	MMP assay	decrease	IC50	163

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Warning	Aggregated GHS information provided by 40 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Warning

Aggregated GHS information provided by 40 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

Synonyms Source: PubChem

171869-95-7	2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinoline, chloride, hy drate;	2628AH
ACM171869957	AKOS015968461	API0008573
C21H22NO4.Cl.H2O	CAS-171869-95-7	CHEMBL2163795
DSSTox_CID_27845	DSSTox_GSID_47869	DSSTox_RID_82598
DTXSID1047869	Dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, chloride, hydrate (1:1:1)	Dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, chloride, monohydrate
NCGC00248731-01	NCGC00257613-01	PALMATINE CHLORIDE 95%
Palmatine chloride hydrate	Palmatine chloride hydrate, 97%	Palmatine chloride monohydrate
Palmatine hydrochloride hydrate	Q27295751	SCHEMBL3321462
ST055756	Tox21_200059	UNII-ZMR2H7M7PK
ZMR2H7M7PK

External IDs

CAS Number	171869-95-7
PubChem Compound	16212317