Compound

D1039 | p-benzoquinone dioxime

Molecular Formula C6H6N2O2
Molecular Weight 138.12
Structure

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 43.30±14.86 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 25.12 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL rat hepatocytes MMP assay Negative IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 149 companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H228 (45.64%): Flammable solid [Danger Flammable solids]


H301 (13.42%): Toxic if swallowed [Danger Acute toxicity, oral]


H302 (86.58%): Harmful if swallowed [Warning Acute toxicity, oral]


H315 (49.66%): Causes skin irritation [Warning Skin corrosion/irritation]


H317 (16.78%): May cause an allergic skin reaction [Warning Sensitization, Skin]


H319 (66.44%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335 (44.97%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


H341 (18.12%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]


H351 (48.32%): Suspected of causing cancer [Warning Carcinogenicity]


H411 (17.45%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P201, P202, P210, P240, P241, P261, P264, P270, P271, P272, P273, P280, P281, P301+P310, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P370+P378, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


P260, P264, P270, P301+P312, P314, P330, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
mouse LD50 oral 1420mg/kg (1420mg/kg) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 29(10), Pg. 15, 1964.
rat LD50 oral 464mg/kg (464mg/kg) Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973,


  • (1E,4E)-benzoquinone dioxime 1,4-Benzochinondioxim 1,4-Benzochinondioxim [Czech]
    1,4-Benzoquinone dioxime 1,4-benzoquinonedioxime 1,4-cyclohexadienedione dioxime
    1,4-di(hydroxyimino)cyclohexa-2,5-diene 105-11-3 2,4-dione, dioxime
    2,5-Cyclohexadiene-1,4-dione, 1,4-dioxime 2,5-Cyclohexadiene-1,4-dione, dioxime 2,5-cyclohexadiene-1,4-dione dioxime
    4-07-00-02074 (Beilstein Handbook Reference) AB0034561 ACMC-2098eu
    AI3-52518 AK-47707 AKOS015901106
    AKOS015920447 ANW-15172 AS-19482
    Actor Q B0090 BR-47707
    BRN 2043234 Benzo-1,4-quinone dioxime Benzo-1,4-quinone dioxime #
    Benzoquinone dioxime C-01782 C19345
    CAS-105-11-3 CCRIS 549 CHEBI:82404
    CHEMBL1585396 CTK0H6045 DSSTox_CID_1222
    DSSTox_GSID_21222 DSSTox_RID_76020 DTXSID8021222
    Dibenzo PQD Dioxime 1,4-cyclohexadienedione Dioxime 2,4-dione
    Dioxime 2,5-cyclohexadiene-1,4-dione Dioxime p-benzoquinone EINECS 203-271-5
    FCH1411688 FCH4121125 FT-0606774
    G-M-F HSDB 2866 KS-00000VOH
    KSC176A4L LNHURPJLTHSVMU-CGXWXWIYSA-N MCULE-6082720028
    MFCD00063636 MGE6YH92Q2 N-(4-nitrosophenyl)hydroxylamine
    NCGC00091127-01 NCGC00091127-02 NCGC00248444-01
    NCGC00248585-01 NCGC00257827-01 NCI-C03850
    NSC 14433 NSC 4774 NSC-14433
    NSC-4774 NSC14433 NSC4774
    P-BENZOQUINONE DIOXIME P-BENZOQUINONE DIOXIME (SEE ALSO: P-BENZOQUINONE MONOOXIME (CAS 637-62-7)); PQD
    Paraquinondioxime Q27155923 QDO
    Quinone dioxime RT-000454 SC-46551
    SCHEMBL8005268 SCHEMBL93568 ST2419770
    ST50988064 TRA0064919 Tox21_200273
    UNII-MGE6YH92Q2 Vulnoc GM W-108793
    WLN: L6Y DYJ AUNQ DUNQ X8737 ZINC100301795
    ZINC3875735 [1,4-Phenylenebis(iminooxy)]radical dioxime p-benzoquinone
    p-Benzo Quinone Dioxime p-Benzoquineone dioxime p-Benzoquinone dioxime, moistened with ca. 30% water
    p-Benzoquinone dioxime, technical, >=90% (TLC) p-Benzoquinone, dioxime p-Benzoquinonedioxime
    p-Nitrosophenylhydroxylamin p-Quinone dioxime p-Quinone oxime
    para-Benzoquinone dioxime para-Quinone oxime

    CAS Number 100045-83-8, 105-11-3
    PubChem Compound 7737