D1051 | phenolphthalein
A
A06AB04 Phenolphthalein
[A06AB] Contact laxatives
[A06A] DRUGS FOR CONSTIPATION
[A06] DRUGS FOR CONSTIPATION
[A] Alimentary tract and metabolism
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 42.78±2.74 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 25.12 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 39.48±16.93 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Danger |
H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity] H350: May cause cancer [Danger Carcinogenicity] H361f ***: Suspected of damaging fertility [Warning Reproductive toxicity] |
P201, P202, P281, P308+P313, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
Aggregated GHS information provided by 1048 companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 2 of 1048 companies. For more detailed information, please visit ECHA C&L website Of the 12 notification(s) provided by 1046 of 1048 companies with hazard statement code(s): H341 (99.62%): Suspected of causing genetic defects [Warning Germ cell mutagenicity] H350 (100%): May cause cancer [Danger Carcinogenicity] H361 (99.62%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P201, P202, P281, P308+P313, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity] H350: May cause cancer [Danger Carcinogenicity] H361f: Suspected of damaging fertility [Warning Reproductive toxicity] |
P201, P202, P281, P308+P313, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity] H351: Suspected of causing cancer [Warning Carcinogenicity] H360: May damage fertility or the unborn child [Danger Reproductive toxicity] H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] |
P201, P202, P260, P264, P270, P281, P308+P313, P314, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
 |
Danger |
H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity] H351: Suspected of causing cancer [Warning Carcinogenicity] H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] |
P201, P202, P260, P261, P264, P270, P272, P280, P281, P302+P352, P305+P351+P338, P308+P313, P314, P321, P333+P313, P337+P313, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| .alpha., .alpha.-Di(p-hydroxyphenyl)phthalide | 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxyphenyl)- | 1(3H)-Isobenzofuranone,3-bis(4-hydroxyphenyl)- |
| 2-[Bis (4-hydroxyphenyl)methyl]benzoic acid | 3, 3-Bis(p-hydroxyphenyl)-1(3H)-isobenzofuranone | 3,3-Bis(4-hydroxyphenyl)-1(3H)-isobenzofuranone |
| 3,3-Bis(4-hydroxyphenyl)-2-benzofuran-1(3H)-one | 3,3-Bis(4-hydroxyphenyl)-2-benzofuran-1(3H)-one # | 3,3-Bis(4-hydroxyphenyl)isobenzofuran-1(3H)-one |
| 3,3-Bis(4-hydroxyphenyl)phthalide | 3,3-Bis(p-hydroxyphenyl)phthalide | 3,3-Bis-(4-hydroxy-phenyl)-3H-isobenzofuran-1-one |
| 3,3-bis (4-hydroxyphenyl)-2-benzofuran-1-on | 3,3-bis(4-hydroxyphenyl)-1,3-dihydro-2-benzofuran-1-one | 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-on |
| 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one | 3,3-bis(4-hydroxyphenyl)-3-hydroisobenzofuran-1-one | 3,3-bis(4-hydroxyphenyl)isobenzofuran-1-one |
| 5-18-04-00188 (Beilstein Handbook Reference) | 6QK969R2IF | 77-09-8 |
| AB00052070_15 | AC-14431 | AI3-09081 |
| AK130019 | AKOS000493033 | ARONIS002962 |
| Agoral | Agoral (Salt/Mix) | Alophen |
| BBL002030 | BCBcMAP01_000174 | BDBM50077844 |
| BIDD:ER0202 | BP-30100 | BRD-K19227686-001-02-0 |
| BRD-K19227686-001-12-9 | BRN 0284423 | BSPBio_002518 |
| C14286 | CAS-77-09-8 | CCG-39112 |
| CCRIS 6266 | CHEBI:34914 | CHEMBL63857 |
| CS-8152 | Chocolax | Colax |
| Correctol | D05456 | DB04824 |
| DSSTox_CID_1125 | DSSTox_GSID_21125 | DSSTox_RID_75956 |
| DTXSID0021125 | Dihydroxyphthalophenone | DivK1c_000929 |
| Doxan (Salt/Mix) | Doxidan | EC 201-004-7 |
| EINECS 201-004-7 | EN300-92962 | EU-0082600 |
| Espotabs | Euchessina | Evac-Q-Kit |
| Evac-Q-Kwik | Evac-Q-Tabs | Evac-U-Gen |
| Evac-V-Lax | F0921-4309 | FGT |
| FT-0659094 | Feen-A-Mint Gum | Feen-A-Mint Laxative Mints |
| Feen-a-mint | FemiLax | Fenolftalein |
| Fenolftalein [Czech] | Fenolftaleina | Fenolftaleina [INN-Spanish] |
| Figsen | HMS1920H04 | HMS2091P06 |
| HMS2236I09 | HMS3374P06 | HMS502O11 |
| HSDB 4161 | HY-D0211 | IDI1_000929 |
| InChI=1/C20H14O4/c21-15-9-5-13(6-10-15)20(14-7-11-16(22)12-8-14)18-4-2-1-3-17(18)19(23)24-20/h1-12,21-22 | KBio1_000929 | KBio2_001557 |
| KBio2_004125 | KBio2_006693 | KBio3_001776 |
| KBioGR_001383 | KBioSS_001557 | KJFMBFZCATUALV-UHFFFAOYSA-N |
| KS-00000YJD | KS-00003W2P | Koprol |
| LS-47 | Lax-Pills | Laxcaps (Salt/Mix) |
| Laxett es | Laxettes | Laxin |
| Laxogen | Lilo | MCULE-5232154932 |
| MFCD00005913 | MLS000069592 | MLS001148397 |
| Medilax | Modane (TN) | Modane Plus (Salt/Mix) |
| NCGC00018200-01 | NCGC00018200-02 | NCGC00018200-03 |
| NCGC00018200-04 | NCGC00018200-05 | NCGC00018200-06 |
| NCGC00018200-07 | NCGC00018200-08 | NCGC00018200-09 |
| NCGC00018200-10 | NCGC00018200-12 | NCGC00023694-03 |
| NCGC00023694-04 | NCGC00023694-05 | NCGC00023694-06 |
| NCGC00023694-07 | NCGC00254039-01 | NCGC00259768-01 |
| NCI-C55798 | NE46883 | NINDS_000929 |
| NSC 10464 | NSC-10464 | NSC-215214 |
| NSC-757271 | NSC10464 | NSC215214 |
| NSC757271 | Opera_ID_1337 | P0094 |
| P0700 | P0701 | P0702 |
| Pharmakon1600-01500480 | Phenolax | Phenolphtaleine |
| Phenolphtaleine [INN-French] | Phenolphthalein (INN) | Phenolphthalein ACS reagent |
| Phenolphthalein Paper, DAB 6 | Phenolphthalein Solution, Alcoholic 1.0% | Phenolphthalein [INN:BAN] |
| Phenolphthalein [USP:INN:BAN] | Phenolphthalein solution, 0.04 % (w/v), pH 7.8-10.0 | Phenolphthalein solution, 0.1 % (w/v), pH 7.8-10.0 |
| Phenolphthalein solution, 0.1 N | Phenolphthalein solution, 0.5 wt. % in ethanol: water (1:1) | Phenolphthalein solution, 1 % (w/v), pH 7.8-10.0 |
| Phenolphthalein, 98.5%, pure, Indicator grade | Phenolphthalein, ACS reagent | Phenolphthalein, ACS reagent, reag. Ph. Eur., indicator, 98-102% (calc. to the dried substance), S. No.: 879 |
| Phenolphthalein, JIS special grade, >=98.0% | Phenolphthalein, SAJ first grade, >=97.0% | Phenolphthalein, United States Pharmacopeia (USP) Reference Standard |
| Phenolphthalein, p.a., ACS reagent | Phenolphthalein, pH indicator | Phenolphthalein, puriss., meets analytical specification of Ph??Eur., BP, 98-101% (calc. to the dried substance); |
| Phenolphthalein,(S) | Phenolphthalein,white | Phenolphthalein,yellow |
| Phenolphthaleinum | Phenolphthaleinum [INN-Latin] | Phenophthalein |
| Phillips Gelcaps | Phthalide 3,-bis(p-hydroxyphenyl)- | Phthalide 3,3,-bis(p-hydroxyphenyl)- |
| Phthalimetten | Phthalin | PubChem7084 |
| Purga | Purgen | Purgophen |
| Q-201555 | Q187921 | SBB008868 |
| SBI-0051481.P003 | SC-74728 | SCHEMBL27670 |
| SMP1_000235 | SMR000059015 | SPBio_001278 |
| SPECTRUM1500480 | SR-01000000112 | SR-01000000112-2 |
| ST072636 | ST24041105 | STK029876 |
| Spectrum2_001279 | Spectrum3_000888 | Spectrum4_000982 |
| Spectrum5_001268 | Spectrum_001077 | Spulmako-lax |
| T8172 | TR-037762 | TRANSGENIC MODEL EVALUATION (PHENOLPHTHALEIN) |
| TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) | Tox21_110838 | Tox21_110838_1 |
| Tox21_202219 | Tox21_300282 | Trilax |
| UNII-6QK969R2IF | VS-01000 | WLN: T56 BVO DHJ D- D-/R DQ 2 |
| Yellow phenolphthalein | Z57233591 | ZINC3831317 |
| alpha-(p-Hydroxyphenyl)-alpha-(4-oxo-2,5-cyclohexadien-1-ylidene)-o-toluic acid | alpha-Di(p-hydroxyphenyl)phthalide | cid_4764 |
| component of Agoral | component of Correctol | component of Correctol (Salt/Mix) |
| component of Feen-A-Mint Pills | component of Feen-A-Mint Pills (Salt/Mix) | phenolphtalein |
| phenolphthalein | s5395 |