D1054 | phloretin
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 4.26±1.22 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 11.22 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 10.60±4.98 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Warning |
Aggregated GHS information provided by 162 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 117 of 162 companies. For more detailed information, please visit ECHA C&L website Of the 5 notification(s) provided by 45 of 162 companies with hazard statement code(s): H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (97.78%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| .beta.-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone | .beta.-(p-Hydroxyphenyl)-2,6-trihydroxypropiophenone | .beta.-(p-Hydroxyphenyl)phloropropiophenone |
| 1-(2,4,6-trihydroxyphenyl)-3-(4-hydroxyphenyl)-1-propanone | 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)- | 2′,4′,6′-Trihydroxy-3-p-hydroxyphenylpropiophenone |
| 2',4',6'-Trihydroxy-3-(4-Hydroxyphenyl)propiophenone | 2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)-propiophenone | 2',4',6'-Trihydroxy-3-(p-hydroxyphenyl)propiophenone |
| 2',4,4',6'-Tetrahydroxy-Dihydrochalcone | 2',4,4',6'-Tetrahydroxydihydrochalcone | 2',6'-Trihydroxy-3-(p-hydroxyphenyl)propiophenone |
| 2uxi | 3-(4-Hydroxy-phenyl)-1-(2,4,6-trihydroxy-phenyl)-propan-1-one | 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanon |
| 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone | 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one | 4,2',4',6'-Tetrahydroxydihydrochalcone |
| 60-82-2 | AB0016775 | AC-7995 |
| ACMC-209mmd | ACN-035397 | ACN-S003569 |
| AK162403 | AKOS015856338 | ANW-33587 |
| AS-14100 | AX8147786 | BBL027375 |
| BCBcMAP01_000040 | BCP28296 | BDBM23446 |
| BIDD:ER0174 | BRD-K15563106-001-02-4 | BRD-K15563106-001-10-7 |
| BSPBio_002851 | C-17278 | C00774 |
| C15H14O5 | CAS-60-82-2 | CC-33738 |
| CCG-38573 | CCRIS 7459 | CHEBI:17276 |
| CHEMBL45068 | CP0082 | CS-1477 |
| CTK3J2061 | DB-053714 | DB07810 |
| DSSTox_CID_2393 | DSSTox_GSID_22393 | DSSTox_RID_76569 |
| DTXSID6022393 | Dihydronaringenin | DivK1c_006429 |
| EINECS 200-488-7 | EU-0101012 | FT-0603256 |
| G50 | GTPL4285 | HMS2224N17 |
| HMS3263K05 | HMS3332J03 | HMS3656I07 |
| HY-N0142 | InChI=1/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H; | KBio1_001373 |
| KBio2_001775 | KBio2_004343 | KBio2_006911 |
| KBio3_002071 | KBioGR_001803 | KBioSS_001775 |
| KM0437 | KS-00000C3P | LMPK12120525 |
| LP01012 | LS-187222 | LS-188085 |
| Lopac-P-7912 | Lopac0_001012 | MCULE-3672992389 |
| MFCD00002288 | MLS000728507 | MLS000859922 |
| MLS006012024 | N1316 | NCGC00015840-01 |
| NCGC00015840-02 | NCGC00015840-03 | NCGC00015840-04 |
| NCGC00015840-05 | NCGC00015840-06 | NCGC00015840-07 |
| NCGC00015840-08 | NCGC00015840-09 | NCGC00094304-01 |
| NCGC00094304-02 | NCGC00094304-03 | NCGC00094304-04 |
| NCGC00260400-01 | NCGC00261697-01 | NSC 407292 |
| NSC-407292 | NSC407292 | O1P165 |
| Oprea1_824722 | P 7912 | P1966 |
| Phloretin(Dihydronaringenin) | Phloretin, 98% | Phloretin, >=99% |
| Phloretin, analytical reference material | Phloretol | Propiophenone, 2',4',6'-trihydroxy-3-(p-hydroxyphenyl)- |
| Propiophenone, 2',4',6'-trihydroxy-3-(p-hydroxyphenyl)- (8CI) | Propiophenone,4',6'-trihydroxy-3-(p-hydroxyphenyl)- | Q-100701 |
| Q2268463 | REGID_for_CID_4788 | RTR-031371 |
| S5J5OE47MK | SBB066137 | SC-18405 |
| SCHEMBL38131 | SDCCGMLS-0066637.P001 | SMP1_000238 |
| SMR000326783 | SPBio_000801 | SPECTRUM300554 |
| SR-01000076081 | SR-01000076081-1 | SR-01000076081-7 |
| SR-01000076081-8 | ST057164 | ST24041477 |
| STL372996 | SW219308-1 | SY017103 |
| SpecPlus_000333 | Spectrum2_000681 | Spectrum3_001036 |
| Spectrum4_001172 | Spectrum5_001698 | Spectrum_001295 |
| TNP00255 | TR-031371 | TRA0006136 |
| Tox21_202854 | Tox21_501012 | UNII-S5J5OE47MK |
| VGEREEWJJVICBM-UHFFFAOYSA-N | ZINC47553 | beta-(4-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone |
| beta-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone | beta-(p-Hydroxyphenyl)phloropropiophenone | cid_4788 |
| phloretin | s2342 |