Compound
D1056 | picropodophyllin
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 0.14±0.02 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 0.05 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | rat | hepatocytes | MMP assay | Negative | IC50 | 163 | ||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
  |
Danger |
Aggregated GHS information provided by 40 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD50 | intramuscular | 3mg/kg (3mg/kg) | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 7, Pg. 249, 1948. | |
| rabbit | LD50 | intravenous | 5mg/kg (5mg/kg) | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 7, Pg. 249, 1948. | |
| rat | LD50 | intravenous | 8700ug/kg (8.7mg/kg) | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 7, Pg. 249, 1948. | |
| chicken | LDLo | subcutaneous | 6250ug/kg (6.25mg/kg) | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 28, Pg. 32, 1891. | |
| cat | LD50 | intravenous | 1700ug/kg (1.7mg/kg) | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 7, Pg. 249, 1948. | |
| cat | LD50 | intramuscular | 4mg/kg (4mg/kg) | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 7, Pg. 249, 1948. | |
| rat | LD50 | subcutaneous | 8mg/kg (8mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951. | |
| cat | LDLo | subcutaneous | 300ug/kg (0.3mg/kg) | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 28, Pg. 32, 1891. | |
| pigeon | LDLo | subcutaneous | 10mg/kg (10mg/kg) | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 28, Pg. 32, 1891. | |
| mouse | LD50 | oral | 100mg/kg (100mg/kg) | PCT Vol. #86-04062, | |
| dog | LDLo | subcutaneous | 1mg/kg (1mg/kg) | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 28, Pg. 32, 1891. | |
| mouse | LD50 | intravenous | 56mg/kg (56mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01679, | |
| rat | LD50 | skin | 500mg/kg (500mg/kg) | PCT Vol. #86-04062, | |
| mouse | LD50 | intraperitoneal | 30mg/kg (30mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 327, 1961. | |
| rabbit | LD50 | skin | 200mg/kg (200mg/kg) | PCT Vol. #86-04062, | |
| frog | LDLo | parenteral | 152mg/kg (152mg/kg) | behavioral: stiffness | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 28, Pg. 32, 1891. |
| mouse | LDLo | subcutaneous | 24600ug/kg (24.6mg/kg) | Toxicon. Vol. 8, Pg. 85, 1970. | |
| rat | LD50 | intraperitoneal | 15mg/kg (15mg/kg) | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 7, Pg. 249, 1948. | |
| (-)PPP | (10R,11S,15R,16R)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0?,?.0??,??]hexadeca-1(9),2,7-trien-12-one | (5R,5aR,8aS,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one |
| (5R,5aR,8aS,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one | (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one | (5R,5aS,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one |
| 0F35AOI227 | 17434-18-3 | 4354-76-1 |
| 477-47-4 | 5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, [5R-(.alpha.-5a.alpha.,8a.alpha.,9.alpha.)] | A12195 |
| AC-20289 | AKOS015965529 | AXL 1717 |
| AXL-1717 | AXL1717 | AXL1717 (Picropodophyllotoxin) |
| BCP18482 | BRD-K81829253-001-02-9 | BRD-K81829253-001-03-7 |
| BRN 0099161 | BSPBio_003481 | CCG-39920 |
| CHEBI:75251 | CHEMBL283120 | CS-1184 |
| DB12802 | DTXSID80197245 | Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R-(5-alpha,5a-alpha,8a-alpha,9-alpha))- |
| Furo[3',7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, [5R-(5.alpha.,5a.alpha.,8a.alpha.,9.alpha.)]-; | GTPL7873 | HMS1923O05 |
| HY-15494 | KBio2_002116 | KBio2_004684 |
| KBio2_007252 | KBio3_002701 | KBioGR_002538 |
| KBioSS_002116 | KS-00000TA3 | LS-70860 |
| NCGC00161923-01 | NCGC00161923-02 | NCGC00161923-04 |
| NSC 36407 | NSC-36407 | NSC36407 |
| Picropodophyllin | Picropodophyllin (8CI) | Picropodophyllin (PPP) |
| Picropodophyllotoxin | Picropodophyllotoxin, >=96% (HPLC), powder | Picropodophyllotoxin;Picropodophyllin;PPP |
| Podophyllotoxin picropodophyllin | Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 alpha))-Isomer | Q27088385 |
| SC-94922 | SCHEMBL159598 | SDCCGMLS-0066757.P001 |
| SPBio_000479 | SPECTRUM1504410 | Spectrum2_000520 |
| Spectrum3_001671 | Spectrum4_001836 | Spectrum5_000631 |
| Spectrum_001636 | UNII-0F35AOI227 | W-5271 |
| WLN: T E5 C665 FVO NO PO OHTT&&J DR CO1 DO1 EO1& JQ | X1203 | YJGVMLPVUAXIQN-HAEOHBJNSA-N |
| ZINC4098919 | picropodophyllin-ppp | s7668 |
| CAS Number | 118627-04-6, 17434-18-3, 4354-76-1, 477-47-4, 518-28-5 |
| PubChem Compound | 72435 |