D1065 | profenofos
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 2.54±1.84 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 6.15 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 13.19±3.19 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
  |
Warning |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H312: Harmful in contact with skin [Warning Acute toxicity, dermal] H332: Harmful if inhaled [Warning Acute toxicity, inhalation] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
 |
Danger |
Aggregated GHS information provided by 232 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302+H312+H332 (16.38%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral acute toxicity, dermal acute toxicity, inhalation] H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H310 (14.22%): Fatal in contact with skin [Danger Acute toxicity, dermal] H311 (66.38%): Toxic in contact with skin [Danger Acute toxicity, dermal] H312 (19.4%): Harmful in contact with skin [Warning Acute toxicity, dermal] H317 (83.19%): May cause an allergic skin reaction [Warning Sensitization, Skin] H331 (14.22%): Toxic if inhaled [Danger Acute toxicity, inhalation] H332 (85.78%): Harmful if inhaled [Warning Acute toxicity, inhalation] H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P262, P264, P270, P271, P272, P273, P280, P301+P312, P302+P350, P302+P352, P304+P312, P304+P340, P310, P311, P312, P321, P322, P330, P333+P313, P361, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Warning |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H312: Harmful in contact with skin [Warning Acute toxicity, dermal] H332: Harmful if inhaled [Warning Acute toxicity, inhalation] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
 |
Warning |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H316: Causes mild skin irritation [Warning Skin corrosion/irritation] H317: May cause an allergic skin reaction [Warning Sensitization, Skin] H320: Causes eye irritation [Warning Serious eye damage/eye irritation] H332: Harmful if inhaled [Warning Acute toxicity, inhalation] H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure] |
P260, P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P309+P311, P312, P321, P330, P332+P313, P333+P313, P337+P313, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 44mg/kg (44mg/kg) | Journal of Agricultural and Food Chemistry. Vol. 30, Pg. 546, 1982. | |
| (+)-Profenofos | (-)-Profenofos | (R)-O-(4-Bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate |
| (S)-O-(4-Bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate | 198P087 | 4-bromo-2-chloro-1-(ethoxy-propylsulfanyl-phosphoryl)oxy-benzene |
| 4-bromo-2-chloro-1-[ethoxy(propylsulfanyl)phosphoryl]oxybenzene | 41198-08-7 | 81116-98-5 |
| 81123-19-5 | AI3-29236 | AKOS015899345 |
| BRN 2150258 | C-21206 | C11H15BrClO3PS |
| C18404 | CAS-41198-08-7 | CC-33936 |
| CCRIS 9291 | CGA 15324 | CHEBI:38845 |
| CHEMBL2138242 | CTK3E8251 | Caswell No. 266AA |
| Curacron | DB-049725 | DSSTox_CID_12464 |
| DSSTox_GSID_32464 | DSSTox_RID_78950 | DTXSID3032464 |
| EC 255-255-2 | EINECS 255-255-2 | EPA Pesticide Chemical Code 111401 |
| FT-0630618 | HSDB 6992 | I562 |
| LS-108416 | LS-108417 | LS-108418 |
| NCGC00164297-01 | NCGC00164297-02 | NCGC00164297-03 |
| NCGC00254657-01 | O-(4-Bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate | O-(4-Bromo-2-chlorophenyl)-O-ethyl-S-propyl phosphorothioate |
| O-(4-Bromo-2-chlorophenyl)-O-ethyl-S-propylphosphorothioate | PROFENOFOS | Phosphorothioic acid, O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl ester |
| Phosphorothioic acid, O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl ester (9CI) | Phosphorothioic acid, O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl ester, (R)- | Phosphorothioic acid, O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl ester, (S)- |
| Phosphorothioic acid, O-(4-bromo-2-chlorophenyl)-O-ethyl S-propyl ester | Phosphorothioic acid, O-(4-bromo-2-chlorophenyl)-O-ethyl-S-propyl ester; | Polycron |
| Profenofos 10 microg/mL in Cyclohexane | Profenofos 100 microg/mL in Cyclohexane | Profenofos 100 microg/mL in Methanol |
| Profenofos [ANSI:BSI:ISO] | Profenofos, PESTANAL(R), analytical standard | Profenofos, analytical standard |
| Profenophos | Q2111894 | QYMMJNLHFKGANY-UHFFFAOYSA-N |
| SCHEMBL25281 | Selecron | Tox21_300752 |
| UNII-7J04O7BS4W component QYMMJNLHFKGANY-QGZVFWFLSA-N | o-(4-Bromo-2-chlorophenyl) o-ethyl S-propyl thiophosphate | o-(4-Bromo-2-chlorophenyl) o-ethyl S-propyl thiophosphate # |
| o-4-bromo-2-chlorophenyl o-ethyl s-propyl phosphorothioate |