Compound

D1065 | profenofos

Molecular Formula C11H15BrClO3PS
Molecular Weight 373.63
Structure

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 2.54±1.84 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 6.15 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 13.19±3.19 rat hepatocytes MMP assay decrease IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H312: Harmful in contact with skin [Warning Acute toxicity, dermal]


H332: Harmful if inhaled [Warning Acute toxicity, inhalation]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

Aggregated GHS information provided by 232 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H302+H312+H332 (16.38%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral


acute toxicity, dermal


acute toxicity, inhalation]


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


H310 (14.22%): Fatal in contact with skin [Danger Acute toxicity, dermal]


H311 (66.38%): Toxic in contact with skin [Danger Acute toxicity, dermal]


H312 (19.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]


H317 (83.19%): May cause an allergic skin reaction [Warning Sensitization, Skin]


H331 (14.22%): Toxic if inhaled [Danger Acute toxicity, inhalation]


H332 (85.78%): Harmful if inhaled [Warning Acute toxicity, inhalation]


H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P261, P262, P264, P270, P271, P272, P273, P280, P301+P312, P302+P350, P302+P352, P304+P312, P304+P340, P310, P311, P312, P321, P322, P330, P333+P313, P361, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H312: Harmful in contact with skin [Warning Acute toxicity, dermal]


H332: Harmful if inhaled [Warning Acute toxicity, inhalation]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H316: Causes mild skin irritation [Warning Skin corrosion/irritation]


H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H320: Causes eye irritation [Warning Serious eye damage/eye irritation]


H332: Harmful if inhaled [Warning Acute toxicity, inhalation]


H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]


P260, P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P309+P311, P312, P321, P330, P332+P313, P333+P313, P337+P313, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
mouse LD50 intraperitoneal 44mg/kg (44mg/kg) Journal of Agricultural and Food Chemistry. Vol. 30, Pg. 546, 1982.


  • (+)-Profenofos (-)-Profenofos (R)-O-(4-Bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate
    (S)-O-(4-Bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate 198P087 4-bromo-2-chloro-1-(ethoxy-propylsulfanyl-phosphoryl)oxy-benzene
    4-bromo-2-chloro-1-[ethoxy(propylsulfanyl)phosphoryl]oxybenzene 41198-08-7 81116-98-5
    81123-19-5 AI3-29236 AKOS015899345
    BRN 2150258 C-21206 C11H15BrClO3PS
    C18404 CAS-41198-08-7 CC-33936
    CCRIS 9291 CGA 15324 CHEBI:38845
    CHEMBL2138242 CTK3E8251 Caswell No. 266AA
    Curacron DB-049725 DSSTox_CID_12464
    DSSTox_GSID_32464 DSSTox_RID_78950 DTXSID3032464
    EC 255-255-2 EINECS 255-255-2 EPA Pesticide Chemical Code 111401
    FT-0630618 HSDB 6992 I562
    LS-108416 LS-108417 LS-108418
    NCGC00164297-01 NCGC00164297-02 NCGC00164297-03
    NCGC00254657-01 O-(4-Bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate O-(4-Bromo-2-chlorophenyl)-O-ethyl-S-propyl phosphorothioate
    O-(4-Bromo-2-chlorophenyl)-O-ethyl-S-propylphosphorothioate PROFENOFOS Phosphorothioic acid, O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl ester
    Phosphorothioic acid, O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl ester (9CI) Phosphorothioic acid, O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl ester, (R)- Phosphorothioic acid, O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl ester, (S)-
    Phosphorothioic acid, O-(4-bromo-2-chlorophenyl)-O-ethyl S-propyl ester Phosphorothioic acid, O-(4-bromo-2-chlorophenyl)-O-ethyl-S-propyl ester; Polycron
    Profenofos 10 microg/mL in Cyclohexane Profenofos 100 microg/mL in Cyclohexane Profenofos 100 microg/mL in Methanol
    Profenofos [ANSI:BSI:ISO] Profenofos, PESTANAL(R), analytical standard Profenofos, analytical standard
    Profenophos Q2111894 QYMMJNLHFKGANY-UHFFFAOYSA-N
    SCHEMBL25281 Selecron Tox21_300752
    UNII-7J04O7BS4W component QYMMJNLHFKGANY-QGZVFWFLSA-N o-(4-Bromo-2-chlorophenyl) o-ethyl S-propyl thiophosphate o-(4-Bromo-2-chlorophenyl) o-ethyl S-propyl thiophosphate #
    o-4-bromo-2-chlorophenyl o-ethyl s-propyl phosphorothioate

    CAS Number 41198-08-7, 81116-98-5, 81123-19-5
    PubChem Compound 38779
    KEGG Compound ID C18404
    ChEBI 38845