Compound
D1079 | rac benidipine hydrochloride
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 14.96±3.18 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 30.83 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | rat | hepatocytes | MMP assay | Negative | IC50 | 163 | ||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Danger |
Aggregated GHS information provided by 42 companies from 3 notifications to the ECHA C&L Inventory. H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P301+P310, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | oral | 322mg/kg (322mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1045, 1990. | |
| rat | LD50 | intravenous | 4400ug/kg (4.4mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1045, 1990. | |
| mouse | LD50 | subcutaneous | 33500ug/kg (33.5mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1045, 1990. | |
| rat | LD50 | subcutaneous | 276mg/kg (276mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1045, 1990. | |
| dog | LDLo | oral | 29300ug/kg (29.3mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1811, 1990. | |
| rat | LD50 | intraperitoneal | 15100ug/kg (15.1mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1045, 1990. | |
| mouse | LD50 | intraperitoneal | 21500ug/kg (21.5mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1045, 1990. | |
| rat | LD50 | oral | 87600ug/kg (87.6mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1045, 1990. | |
| mouse | LD50 | intravenous | 2500ug/kg (2.5mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1045, 1990. | |
| (+-)-Benidipine hydrochloride | (+/-)-(r)-3-[(r)-1-benzyl-3-piperidyl] methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate hydrochloride | (-)-alpha-Benidipine hydrochloride |
| (3R)-1-Benzyl-3-piperidinyl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1) | (R)-3-((R)-1-Benzylpiperidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride | 1-(BENZYLMETHYL)-3-PIPERIDINYL 1,4-DIHYDRO-2,6-DIM |
| 105979-17-7 | 129262-07-3 | 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (4R)-rel- |
| 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (R*,R*)-(+-)- | 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (R-(R*,R*))- | 3-((R)-1-benzylpiperidin-3-yl) 5-methyl (R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride |
| 5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate,hydrochloride; | 599B745 | 91599-74-5 |
| AB2000423 | AKOS015895638 | AS-14293 |
| BCP0726000287 | BCP9000391 | BCPP000347 |
| BENIDIPINE HCl | Benidipine (+-)-alpha-form HCl | Benidipine (+-)-alpha-form hydrochloride |
| Benidipine (hydrochloride) | Benidipine hydrochloride (JP17) | Benidipine hydrochloride [JAN] |
| Benidipine hydrochloride, >=98% (HPLC) | C28H31N3O6.HCl | CAS-91599-74-5 |
| CCG-100952 | CCG-221233 | CHEMBL2359165 |
| CHEMBL3190257 | CPD002529677 | CS-5152 |
| CTK8F7953 | Coniel (TN) | Coniel R |
| D02045 | DSSTox_CID_28976 | DSSTox_GSID_49050 |
| DSSTox_RID_83241 | DTXSID2049050 | HY-B1448 |
| K668 | KS-00000XIL | KW 3049 |
| KW-3049 | LS-131303 | LS-131304 |
| MLS001401418 | NC00202 | NCGC00185768-01 |
| Q27236529 | SAM001246672 | SC-76102 |
| SCHEMBL349506 | SMR000469192 | SW197582-2 |
| Tox21_113598 | UNII-0A6746FWDL component KILKDKRQBYMKQX-MIPPOABVSA-N | benidipine hydrochloride |
| rac Benidipine hydrochloride | s2017 |