Drug
D1083 | riboflavin
S
A
S01XA26 Riboflavin
[S01XA] Other ophthalmologicals
[S01X] OTHER OPHTHALMOLOGICALS
[S01] OPHTHALMOLOGICALS
[S] Sensory organs
A11HA04 Riboflavin (vit b2)
[A11HA] Other plain vitamin preparations
[A11H] OTHER PLAIN VITAMIN PREPARATIONS
[A11] VITAMINS
[A] Alimentary tract and metabolism
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 7.02±1.78 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 11.22 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 31.27±8.72 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 30 mins | mouse | liver mitochondria | Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss) | Negative | EC20 | 36 | |
| RESPIRATION | 264.6 µM | 60 mins | mouse | liver mitochondria | Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. | decrease | EC20 | 36 |
| RESPIRATION | 182.8 µM | 60 mins | mouse | liver mitochondria | Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. | decrease | EC20 | 36 |
| SWELLING | 672.3 µM | 30 mins | mouse | liver mitochondria | swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling ) | increase | EC20 | 36 |
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| NADH:ubiquinone reductase | 264.6 µM | 60 mins | mouse | liver mitochondria | Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. | inhibit | EC20 | 36 |
| Succinate dehydrogenase | 182.8 µM | 60 mins | mouse | liver mitochondria | Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. | inhibit | EC20 | 36 |
| Cytochrome c | > 400 µM | 30 mins | mouse | liver mitochondria | Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline) | release | EC20 | 36 |
| ()-Riboflavin | (-)-Riboflavin (Vitamin B2) solution, 100 mug/mL (Methanol:0.1% Ammonium acetate in Water (1:1)), ampule of 1 mL, analytical standard | (-)-Riboflavin, 100 mug/mL (1% ammonium acetate in 50:50 methanol:water), certified reference material, ampule of 1 mL |
| (-)-Riboflavin, 97-103% | (-)-Riboflavin, BioReagent, suitable for cell culture, suitable for insect cell culture, >=98% | (-)-Riboflavin, acrylamide photopolymerization tested |
| (-)-Riboflavin, from Eremothecium ashbyii, >=98% | (-)-Riboflavin, meets USP testing specifications | (-)-Riboflavin, tested according to Ph.Eur. |
| (-)-Riboflavin-13C4,15N2 (Vitamin B2-13C4,15N2) solution, 100 mug/mL (1% ammonium acetate in 50:50 methanol:water), certified reference material, ampule of 1 mL | (-)-riboflavin | 1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-ribitol |
| 1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol | 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-D-ribitol | 13123-37-0 |
| 1kyv | 2ccb | 2fl5 |
| 2vx9 | 2vxa | 4d1y |
| 5-deoxy-5-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-D-ribitol | 6,7-Dimethyl-9-D-ribitylisoalloxazine | 6,7-Dimethyl-9-ribitylisoalloxazine |
| 7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine | 7,8-Dimethyl-10-ribitylisoalloxazine | 7,8-dimethyl-10-((2S,3S,4R)-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione |
| 7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-Benzo[g]pteridine-2,4(3H,10H)-dione | 7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione | 7,8-dimethyl-10-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]-2H,3H,4H,10H-benzo[g]pteridine-2,4-dione |
| 7,8-dimethyl-10-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]benzo[g]pteridine-2,4-dione | 7,8-dimethyl-10-[(2S,3S,4R)-2,3,4,5-tetrakis(oxidanyl)pentyl]benzo[g]pteridine-2,4-dione | 83-88-5 |
| A840676 | AB0008077 | AB2000637 |
| AI3-14697 | AS-15936 | AUNGANRZJHBGPY-SCRDCRAPSA-N |
| Aqua-Flave | BDBM50362895 | BIR0613 |
| BPBio1_000692 | BSPBio_000628 | Beflavin |
| Beflavine | Benzo(g)pteridine-2,4(3H,10H)-dione, 7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)- | Benzo[g]pteridine riboflavin deriv. |
| Bisulase (TN) | C00255 | C17H20N4O6 |
| CAS-83-88-5 | CCRIS 1904 | CHEBI:17015 |
| CHEMBL1534 | CS-2567 | Certified Reference Material |
| D-Ribitol, 1-deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo(g)pteridin-10(2H)-yl)- | D00050 | DB00140 |
| DSSTox_CID_1777 | DSSTox_GSID_21777 | DSSTox_RID_76321 |
| DTXSID8021777 | Dermadram | E101 |
| EINECS 201-507-1 | Epitope ID:161730 | Fiboflavin |
| Flavaxin | Flavin BB | Flaxain |
| Food Yellow 15 | GTPL6578 | HMS2096P10 |
| HSDB 817 | HY-B0456 | HYRE |
| Hyflavin | INS NO. 101(I) | InChI=1/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s; |
| Isoalloxazine, 7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)- | Isoalloxazine, 7,8-dimethyl-10-D-ribityl- | LS-2192 |
| Lactobene | Lactoflavin | Lactoflavine |
| MFCD00005022 | MLS001066391 | NCGC00017291-05 |
| NCGC00091288-01 | NCGC00091288-02 | NCGC00091288-03 |
| NCGC00091288-05 | NCGC00179498-01 | NCGC00256408-01 |
| NCGC00259182-01 | NCI-0033298 | NSC 33298 |
| NSC-33298 | Prestwick3_000634 | Prestwick_442 |
| Q130365 | R0020 | R437 |
| RIBOFLAVINE | Ribipca | Ribocrisina |
| Riboderm | Riboflavin (B2), analytical standard | Riboflavin (JP17/USP/INN) |
| Riboflavin (Vit B2) | Riboflavin (Vitamin B2) | Riboflavin [USAN:INN:JAN] |
| Riboflavin [USP:INN:BAN] | Riboflavin for peak identification, European Pharmacopoeia (EP) Reference Standard | Riboflavin(B2);7,8-Dimethyl-10-((2S,3S,4R)-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione |
| Riboflavin, European Pharmacopoeia (EP) Reference Standard | Riboflavin, Pharmaceutical Secondary Standard | Riboflavin, United States Pharmacopeia (USP) Reference Standard |
| Riboflavin-Vitamin-B2 | Riboflavina | Riboflavina [INN-Spanish] |
| Riboflavine | Riboflavine [INN-French] | Riboflavinequinone |
| Riboflavinum | Riboflavinum [INN-Latin] | Ribosyn |
| Ribotone | Ribovel | Russupteridine Yellow III |
| SCHEMBL7706 | SMR000112236 | ST2413784 |
| San Yellow B | TLM2976OFR | Tox21_110813 |
| Tox21_111714 | Tox21_111714_1 | Tox21_201633 |
| Tox21_302980 | UNII-TLM2976OFR | VITAMIN B2 |
| Vitaflavine | Vitamin B2;E101 | Vitamin Bi |
| Vitamin G | Vitasan B2 | Y-9791 |
| ZINC2036848 | ZX-AFC000568 | riboflavin |
| s2540 | vitamin B2 |