Drug
D1086 | rimonabant
A
A08AX01 Rimonabant
[A08AX] Other antiobesity drugs
[A08A] ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
[A08] ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
[A] Alimentary tract and metabolism
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 25.60±1.67 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 17.34 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 17.45±2.83 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| BASAL RESPIRATION | 10 mM | zebrafish | XFe24 Extracellular Flux Analyzer | Negative | 88 | |||
| BASAL RESPIRATION | 10 mM | zebrafish | XFe24 Extracellular Flux Analyzer | Negative | 88 | |||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
  |
Danger |
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P260, P264, P270, P273, P314, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| 143881-EP2287165A2 | 143881-EP2287166A2 | 143881-EP2292620A2 |
| 168273-06-1 | 1H-Pyrazole-3-carboxamide, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl- | 1H-Pyrazole-3-carboxamide,5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl- |
| 4CH-015711 | 5-(4-CHLOROPHENYL)-1-(2,4-DICHLOROPHENYL)-4-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID PIPERIDIN-1-YLAMIDE | 5-(4-Chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide |
| 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide | 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1-piperidinyl)-3-pyrazolecarboxamide | 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1-piperidyl)pyrazole-3-carboxamide |
| 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide | 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidin-1-yl-pyrazole-3-carboxamide | 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide |
| 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidino-1H-pyrazole-3-carboxamide | 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-n-piperidinopyrazole-3-carboxamide | 5-(p-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidinopyrazole-3-carboxamide |
| 81R131 | A 281 | A11547 |
| A810956 | AB0056959 | AB01566860_01 |
| AC-163720 | AC-731 | AK-61012 |
| AKOS005266728 | AM84578 | API0004077 |
| AS-37280 | AY6; | Acomplia |
| Acomplia (TN) | B1429 | BBL030198 |
| BCP07803 | BDBM21278 | BR-61012 |
| C-22624 | C14319 | CAS-168273-06-1 |
| CC-34263 | CHEBI:34967 | CHEMBL111 |
| CS-0645 | CTK8E8269 | D05731 |
| DB-011649 | DB06155 | DSSTox_CID_26453 |
| DSSTox_GSID_46453 | DSSTox_RID_81627 | DTXSID3046453 |
| EX-A688 | FT-0631194 | GP8358 |
| GTPL743 | HMS3604M05 | HMS3657O15 |
| HY-14136 | J-010440 | JZCPYUJPEARBJL-UHFFFAOYSA-N |
| KS-00000NTG | L000572 | LS-128155 |
| MCULE-7311256045 | MLS004774043 | MLS006011772 |
| N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide | N-piperidino-5-(4-chlorophenyl)-1(2,4-dichlorophenyl)-4-methyl-pyrazole-3-carboxamide | N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3-pyrazolecarboxamide |
| NCGC00164572-01 | NCGC00164572-02 | PYR405 |
| Q412529 | RML78EN3XE | RTR-007307 |
| Rimonabant | Rimonabant (JAN/USAN/INN) | Rimonabant (SR141716) |
| Rimonabant - from sample | Rimonabant [USAN:INN:JAN] | Rimonabant [USAN:INN] |
| Rimonabant(SR141716) | Rimoslim | S-3507 |
| SB19549 | SCHEMBL38637 | SMR003500713 |
| SR 141716 | SR-01000884001 | SR-01000884001-1 |
| SR-14171 | SR-141716 | SR-141716A |
| SR141,716A | SR141716 | SR141716A |
| ST2418566 | STK642500 | SW220167-1 |
| TR-007307 | Tox21_112200 | Tox21_112200_1 |
| UNII-RML78EN3XE | ZINC1540228 | Zimulti |
| [3H]RIMONABANT | [3H]SR141716A | rimonabant-sr141716 |
| s3021 |