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Drug

D1089 | selenious acid

Molecular Formula H2O3Se
Molecular Weight 128.99
Structure
State solid
Volume of distribution Following oral intake and absorption, selenium from sodium selenite is found in the highest concentrations in the liver and kidneys of humans and animals [L1924]. In one study, tissue samples taken at autopsy from 46 healthy individuals killed in accidents and from 75 corpses of victims of various diseases to analyze selenium levels and distribution [A32296]. The per-weight-unit basis of selenium levels ng/gm in wet in tissues decreased in the following order: kidney (469) > liver > spleen > pancreas > heart > brain > lung > bone > skeletal muscle. The highest proportion of body selenium was found in skeletal muscles (27.5%) [A32296], [L1985]. Significantly less selenium was measured in bones (16%) and blood (10%). In the tissues of cancer corpses, the selenium levels were lower than levels in the control group. The lowest selenium concentrations were measured in alcoholic livers [A32296].
Route of elimination Selenium is eliminated mainly in the urine. However, significant endogenous losses through the feces can also occur [L1984]. The rate of excretion varies with the chemical form of selenium used in supplementation and the route of administration. Other minor routes of elimination are lungs and skin [L1922]. Analysis of 72-hour urine sampling from a study of 48 Norwegian women given a 200 μg supplement of selenium in the form of selenite indicated approximately 50% absorption of selenite [L1924].
Half life 30 days in beagle dogs [L1910].
Absorption The absorption of selenite following oral administration approximately 40-70% of an oral dose, based on studies done in humans [L1924]. Selenoprotein P, the plasma form of selenium, contains at least 40% of the total selenium in plasma [L1987]. Deletion of the gene for selenoprotein P in mouse models alters the distribution of selenium in body tissues suggesting that selenoprotein P is necessary for selenium transport [A32296].

A

A12CE02 Sodium selenite


[A12CE] Selenium


[A12C] OTHER MINERAL SUPPLEMENTS


[A12] MINERAL SUPPLEMENTS


[A] Alimentary tract and metabolism

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 15.97±22.77 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL human HepG2 MMP assay Negative IC50 163
MEMBRANE POTENTIAL 44.11±26.85 rat hepatocytes MMP assay decrease IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 204 companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]


H331 (99.51%): Toxic if inhaled [Danger Acute toxicity, inhalation]


H373 (42.16%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


H400 (98.53%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410 (99.51%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P260, P261, P264, P270, P271, P273, P301+P310, P304+P340, P311, P314, P321, P330, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]


H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]


H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]


H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


 P260, P264, P270, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P307+P311, P310, P314, P321, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]


H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]


H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


 P260, P264, P270, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P314, P321, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rat LDLo intraperitoneal 10mg/kg (10mg/kg) National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 28, 1953.
mouse LD50 intravenous 11mg/kg (11mg/kg) U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#05656,
rat LDLo oral 25mg/kg (25mg/kg) National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 28, 1953.


  • 7783-00-8 AKOS015960374 CAS-7783-00-8
    CCG-35433 CCRIS 5530 CHEBI:26642
    CHEMBL2009089 CTK2H8628 D05814
    DB11127 DSSTox_CID_4300 DSSTox_GSID_24300
    DSSTox_RID_77360 DTXSID9024300 EC 231-974-7
    EINECS 231-974-7 F6A27P4Q4R HSDB 6065
    KS-0000193L LS-144800 MCAHWIHFGHIESP-UHFFFAOYSA-N
    MFCD00011331 Monohydrated selenium dioxide NCGC00248596-01
    NCGC00257961-01 NCI60_003085 NCIMech_000026
    Q413722; SELENIOUS ACID Selenious acid (H2SeO3)
    Selenious acid (USP) Selenious acid [USP] Selenious acid, 98%
    Selenious acid, 99.999%, (trace metal basis) Selenite (SeO32-) Selenite ion (SeO32-)
    Selenite ion(2-) Selenium dioxide, monohydrated Selenium, Reference Standard Solution
    Selenous acid Selenous acid, 98% Selenous acid, 99.999% trace metals basis
    Selenous acid, Puratronic? Selenous acid, p.a., 95.0% TR-024855
    Tox21_200407 UN-3283 UNII-F6A27P4Q4R
    VZ36877 [SeO(OH)2] dihydroxidooxidoselenium
    selenige Saeure selenious acid,selenous acid,monohydrated selenium dioxide

    DrugBank DB11127
    CAS Number 23428-84-4, 7783-00-8
    PubChem Compound 1091
    KEGG Drug D05814
    ChEBI 26642