MITOTOX

Compound

D1094 | sodium 2-phenylphenate tetrahydrate

Properties

Molecular Formula	C12H17NaO5
Molecular Weight	264.25
Structure

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Species	Model	Method	Action	Positive criterion	Reference
MEMBRANE POTENTIAL	18.53±0.00	human	qHTS-HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	31.62	human	HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL		rat	hepatocytes	MMP assay	Negative	IC50	163

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Danger	Aggregated GHS information provided by 545 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 5 of 545 companies. For more detailed information, please visit ECHA C&L website Of the 5 notification(s) provided by 540 of 545 companies with hazard statement code(s): H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H314 (81.67%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] H315 (18.33%): Causes skin irritation [Warning Skin corrosion/irritation] H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H335 (18.33%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H400 (18.33%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P260, P261, P264, P270, P271, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P362, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Danger

Aggregated GHS information provided by 545 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria by 5 of 545 companies. For more detailed information, please visit ECHA C&L website

Of the 5 notification(s) provided by 540 of 545 companies with hazard statement code(s):

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H314 (81.67%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H315 (18.33%): Causes skin irritation [Warning Skin corrosion/irritation]

H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H335 (18.33%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure

Respiratory tract irritation]

H400 (18.33%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P260, P261, P264, P270, P271, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P362, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

Synonyms Source: PubChem

2-HYDROXYBIPHENYL SODIUM SALTTETRAHYDRATE	2-Hydroxybiphenyl sodium salt tetrahydrate	2-Phenylphenol sodium salt tetrahydrate
2-Phenylphenol sodium salt tetrahydrate, technical;	6152-33-6	CAS-6152-33-6
CHEMBL1903906	DSSTox_CID_20794	DSSTox_GSID_40794
DSSTox_RID_79602	DTXSID1040794	E232
LS40587	NCGC00091595-07	NCGC00164321-01
NCGC00255652-01	Sodium 2-phenylphenate tetrahydrate	Sodium [1,1'-biphenyl]-2-olate tetrahydrate
Sodium, (2-biphenylyloxy)-, tetrahydrate	Tox21_112097	Tox21_112097_1
Tox21_301387

External IDs

CAS Number	132-27-4, 6152-33-6
PubChem Compound	517383