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Compound

D1100 | spiclomazine hydrochloride

Molecular Formula C22H25Cl2N3OS2
Molecular Weight 482.5
Structure

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 34.80±2.36 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL human HepG2 MMP assay Negative IC50 163
MEMBRANE POTENTIAL rat hepatocytes MMP assay Negative IC50 163

Organism Test type Route Dose (normalized dose) Effect Source
rat LD50 subcutaneous > 5490mg/kg (5490mg/kg) Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 487, 1970.
mouse LD50 oral 3800mg/kg (3800mg/kg) Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 487, 1970.
rat LD50 oral 3800mg/kg (3800mg/kg) Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 487, 1970.
mouse LD50 subcutaneous > 5490mg/kg (5490mg/kg) Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 487, 1970.
rat LD50 intraperitoneal 2950mg/kg (2950mg/kg) Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 487, 1970.
mouse LD50 intraperitoneal 3200mg/kg (3200mg/kg) Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 487, 1970.


  • 1-Thia-4, 8-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-, monohydrochloride 1-Thia-4, 8-[3-(2-chlorophenothiazin-10-yl)propyl]-, monohydrochloride 1-Thia-4,8-diazaspiro(4.5)decan-3-one, 8-(3-(2-chlorophenothiazin-10-yl)propyl)-, hydrochloride
    1-Thia-4,8-diazaspiro(4.5)decan-3-one, 8-(3-(2-chlorophenothiazin-10-yl)propyl)-, monohydrochloride 1-Thia-4,8-diazaspiro(4.5)decan-3-one, 8-(3-(2-chlorophenothiazin-10-yl)propyl)-, monohydrochloride (8CI) 1-Thia-4,8-diazaspiro(4.5)decan-3-one, 8-(3-(2-chlorophenothiazin-10-yl)propyl)-,hydrochloride;
    27007-85-8 8-(3-(2-Chlorophenothiazin-10-yl)propyl)-1-thia-4,8-diazaspiro(4.5)decan-3-one hydrochloride 8-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one hydrochloride
    APY 606 APY-606 C22H24ClN3OS2.HCl
    CAS-27007-85-8 CHEBI:31423 CHEMBL1967529
    Clospirazine HCl Clospirazine hydrochloride D01487
    DSSTox_CID_3593 DSSTox_GSID_23593 DSSTox_RID_77099
    DTXSID4023593 Diceplon Disepron
    LS-150121 N6B142V0U0 NCGC00014648-01
    NSC 290956 NSC-290956 NSC290956
    Q27284615 SCHEMBL3501689 Spiclomazine hydrochloride
    Spiclomazine hydrochloride (JAN) Tox21_110055 UNII-N6B142V0U0

    CAS Number 27007-85-8, 2791-51-7
    PubChem Compound 122820
    KEGG Drug D01487
    ChEBI 135727