Compound
D1102 | su-5416
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 12.53±1.78 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 13.77 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 11.01±1.78 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Warning |
Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| (3Z)-3-[(3,5-DIMETHYL-1H-PYRROL-2-YL)METHYLIDENE]-2,3-DIHYDRO-1H-INDOL-2-ONE | (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one | (Z)-3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)indolin-2-one |
| (Z)-SU 5416 | 1,3-Dihydro-3-[(3,5-dimethyl-1H-pyrrol-2-yl) | 1,3-Dihydro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-2H-indol-2-one |
| 194413-58-6 | 2033AH | 204005-46-9 |
| 2712AH | 2H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro-, (3Z)- | 2H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro-, (Z)- |
| 2H-Indol-2-one, 3-(3,5-dimethyl-1H-pyrrol-2-yl)methylene)- 1,3-dihydro-, (Z)- | 2H-Indol-2-one,5-dimethyl-2-pyrrolyl)methylene]- | 2x2m |
| 3-((Z)-(3,5-Dimethylpyrrol-2-yl)methylene)-2-indolinone | 3-(1-(3,5-Dimethyl-1H-pyrrol-2-yl)meth-(Z)-ylidene)-2-oxo-2,3-dihydroindole | 3-[(2,4-Dimethylpyrrol-5-yl)methylidene]-indolin-2-one |
| 3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone | 3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-indolin-2-one | 3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]indolin-2-one |
| 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro- 2H-indol-2-one | 3-[(3,5-Dimethyl-2H-pyrrol-2-ylidene)methyl]-1H-indol-2-ol | 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one |
| 3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylene]-1,3-dihydro-2h-indol-2-one | 3-[1-(3,5-dimethyl-1h-pyrrol-2-yl)-meth-(z)-ylidene]-2-oxo-2,3-dihydro-indole; | 71IA9S35AJ |
| A12437 | AB0094985 | AK174866 |
| AK174898 | AKOS015994557 | AOB6828 |
| BCP06068 | BDBM4810 | BRD-K63504947-001-05-5 |
| BS0306 | CCG-205186 | CHEBI:91083 |
| CHEMBL276711 | CS-1225 | D05819 |
| DB06436 | ES-0010 | EU-0101110 |
| EX-A2158 | GTPL5056 | H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro- |
| HMS2234L12 | HMS3229O13 | HMS3263M22 |
| HMS3268J13 | HMS3413H10 | HMS3648O12 |
| HMS3677H10 | HSCI1_000303 | HY-10374 |
| InSolution&trade | J-013281 | LP01110 |
| LS-193151 | LS-83886 | Lopac0_001110 |
| MFCD01940922 | MLS001074896 | MLS001332519 |
| MLS001332520 | NCGC00094381-01 | NCGC00094381-02 |
| NCGC00094381-03 | NCGC00094381-04 | NCGC00094381-05 |
| NCGC00261795-01 | NSC 696819 | NSC-696819 |
| NSC696819 | Q7449140 | QC-11357 |
| QCR-86 | RT-016226 | S 8442 |
| SC-96714 | SCHEMBL19571 | SCHEMBL8190 |
| SIBNPBQTUXWRMZ-ZSOIEALJSA-N | SMR000568416 | SR-01000076044 |
| SR-01000076044-2 | SR-01000076044-8 | SU 5416 |
| SU-5416 | SU005416 | SU5146 |
| SU5416 | SU5416 | SW219791-1 |
| Semaxanib | Semaxanib | Semaxanib (SU5416) |
| Semaxanib (USAN/INN) | Semaxanib [USAN:INN] | Semaxanib, Semoxind, TSU-16, NSC-696819, SU-5416 |
| Semaxinib | Semaxnib | Semoxind |
| Sugen 5416 | TSU 16 | TSU-16 |
| Tox21 111271 | Tox21_501110 | UNII-71IA9S35AJ |
| VEGF Receptor 2 Kinase Inhibitor III | VEGF Receptor 2 Kinase Inhibitor III | VEGFR2 Kinase Inhibitor III |
| W-5403 | WUWDLXZGHZSWQZ-WQLSENKSSA-N | Z-Semaxanib |
| ZINC12410091 | cid_5329098 | methylene]-2H-indol-2-one |
| s2845 | semaxanib-su5416 |