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Drug

D1105 | talniflumate

Molecular Formula C21H13F3N2O4
Molecular Weight 414.3
Structure
State solid
Clearance This drug undergoes extensive first pass effect.
Volume of distribution In 12 subjects after a single oral administration, total plasma clearance of the main metabolite, niflumic acid, averaged 45 ml/min giving a distribution volume of 0.12 l/kg on average [A31964].
Protein binding Niflumic acid, the active form of Talniflumate, is weak acid that is strongly bound to plasma proteins. Bioavailability was 100% in a study of 12 volunteers. It is a weak acid, strongly bound to plasma proteins [A31964].
Half life Approximately 2h in 12 subjects [A31964]

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 27.00±2.56 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL human HepG2 MMP assay Negative IC50 163
MEMBRANE POTENTIAL 15.95±6.68 rat hepatocytes MMP assay decrease IC50 163


  • (3-oxidanylidene-1H-2-benzofuran-1-yl) 2-[[3-(trifluoromethyl)phenyl]amino]pyridine-3-carboxylate (3-oxo-1H-2-benzofuran-1-yl) 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate 2-(.alpha.,.alpha.,.alpha.-Trifluoro-m-toluidino)nicotinic acid phthalidyl ester
    2-(alpha,alpha,alpha-Trifluoro-m-toluidino)nicotinic acid phthalidyl ester 2-[3-(trifluoromethyl)anilino]-3-pyridinecarboxylic acid (3-oxo-1H-isobenzofuran-1-yl) ester 2-[[3-(Trifluoromethyl)phenyl]amino]-1,3-dihydro-3-oxo-1-isobenzofuranyl 3-pyridinecarboxylic acid ester
    2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid 1,3-dihydro-3-oxo-1-isobenzofuranyl ester; 3-Ftalidilico del acido 2-((3-(trifluormetil)fenil)amino)-3-piridincarboxilico 3-Ftalidilico del acido 2-((3-(trifluormetil)fenil)amino)-3-piridincarboxilico [Spanish]
    3-Phthalidyl ester of 2-((3-(trifluoromethyl)phenyl)amino)-3-pyridinecarboxylic acid 3-Pyridinecarboxylic acid, 2-((3-(trifluoromethyl)phenyl)amino)-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester 3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester
    3-oxo-1,3-dihydroisobenzofuran-1-yl 2-(3-(trifluoromethyl)phenylamino)nicotinate 66898-62-2 898T622
    A835581 AB0015459 AC-14144
    AKOS015895754 ANMLJLFWUCQGKZ-UHFFFAOYSA-N API0004315
    BA 7602-06 BRD-A98378129-001-01-4 BRN 0503261
    Ba-7602-06 C-21964 C21H13F3N2O4
    CAS-66898-62-2 CC-34632 CHEBI:91991
    CHEMBL1081506 CTK8G3296 D02701
    DB-054972 DB09295 DSSTox_CID_26740
    DSSTox_GSID_46740 DSSTox_RID_81869 DTXSID3046740
    FT-0630769 HMS3269M13 HMS3413D19
    HMS3677D19 KS-000017U3 KS-5130
    LS-96640 Lomucin M935
    MSI-1995 NCGC00167754-01 NCGC00167754-02
    NICOTINIC ACID, 2-(alpha,alpha,alpha-TRIFLUORO-m-TOLUIDINO)-, PHTHALIDYL ESTER Nicotinic acid, 2-(.alpha.,.alpha.,.alpha.-trifluoro-m-toluidino)-, phthalidyl ester Phthalidyl 2-(.alpha.,.alpha.,.alpha.-trifluoro-m-toluidino)nicotinate
    Phthalidyl 2-(3-trifluoromethylanilino)nicotinate Phthalidyl 2-(alpha,alpha,alpha,-trifluoro-m-toluidino)nicotinate Phthalidyl 2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinate
    Q22075910 SCHEMBL23691 Somalgen
    Somalgen (TN) Talniflumate Talniflumate (USAN/INN)
    Talniflumate [USAN:INN] Talniflumato Talniflumato [INN-Spanish]
    Talniflumatum Talniflumatum [INN-Latin] Tox21_112584
    Tox21_112584_1 ZINC000000601275 [(1R)-3-oxo-1H-2-benzofuran-1-yl] 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate
    phthalidyl 2-(3'-trifluormethylanilino)-pyridin-3-carboxylate phthalidyl 2-(3-trifluoromethylanilino)-3-pyridinecarboxylate s6439

    DrugBank DB09295
    CAS Number 101626-70-4, 66898-62-2
    PubChem Compound 48229
    KEGG Drug D02701
    ChEBI 91991