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2021 MitoTox | (CC BY-NC 4.0)
Drug

D1106 | tamibarotene

Molecular Formula C22H25NO3
Molecular Weight 351.4
Structure
State solid
Protein binding Over 99%, predominantly to serum albumin.

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 25.68±1.05 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 13.77 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 9.06±6.66 rat hepatocytes MMP assay decrease IC50 163


  • 08V52GZ3H9 121GE003 2cbr
    4-(((5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)amino)carbonyl)benzoic acid 4-((5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl)benzoic acid 4-((5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl)benzoic acid
    4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylcarbamoyl)benzoic acid 4-[(1,1,4,4-tetramethyltetralin-6-yl)carbamoyl]benzoic acid 4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic acid
    4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid 497T515
    4CH-007027 94497-51-5 A80;
    AB0009956 AC-7049 AK-72889
    AKOS015902693 AM-80 AM20060757
    API0005327 AS-14083 AX8113755
    Am 80 Am80 Amnoid
    Amnoid (TN) Amnolake Amnoleuk
    BCP07492 BDBM50061625 BR-72889
    Benzoic acid, 4-(((5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino)carbonyl)- C-20659 C12864
    CAS-94497-51-5 CC-34634 CHEBI:32181
    CHEMBL25202 CS-0654 CTK8E9821
    D01418 DB04942 DSSTox_CID_26853
    DSSTox_GSID_46853 DSSTox_RID_81962 DTXSID5046853
    EBD989 FT-0080835 FT-0601534
    GTPL2648 HMS3652H04 HMS3743C03
    HY-14652 INNO-507 J90051
    LS-38350 MFCD00866188 MLS003899239
    MLS004774034 MLS006011150 MUTNCGKQJGXKEM-UHFFFAOYSA-N
    N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl)-2-naphthyl)terephthalamic acid N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)terephthalamic acid NCGC00181111-01
    NCGC00181111-02 NCI60_004716 NSC 608000
    NSC-608000 NSC608000 OMS-0728
    Q7681221 S-7407 SCHEMBL36207
    SMR002530320 ST24028715 SW219913-1
    TM-411 TOS-80 TOS-80T
    TR-029540 Tamibaro Tamibarotene
    Tamibarotene (JAN/INN) Tamibarotene [INN] Tamibarotene(Am-80)
    Tamibarotene, >=98% (HPLC) Terephthalic acid mono-5,5,8,8-tetramethyl- 5,6,7, 8-tetrahydro-2-naphthylamide Terephthalic acid mono-5,8,8-tetramethyl- 5,6,7,8-tetrahydro-2-naphthylamide
    Tox21_112725 Tox21_112725_1 UNII-08V52GZ3H9
    Z-208 ZINC000000538415 ZINC538415
    retinobenzoic acid s4260

    DrugBank DB04942
    CAS Number 94497-51-5
    PubChem Compound 108143
    KEGG Compound ID C12864
    KEGG Drug D01418
    ChEBI 32181