Compound

D1107 | tamsulosin hydrochloride

Molecular Formula C20H29ClN2O5S
Molecular Weight 445
Structure

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 27.20±2.92 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 30.83 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 25.14±8.04 rat hepatocytes MMP assay decrease IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 132 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H302 (99.24%): Harmful if swallowed [Warning Acute toxicity, oral]


H315 (34.85%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (34.85%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335 (34.09%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rat LD50 intravenous 70mg/kg (70mg/kg) Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5071, 1990.
mouse LD50 subcutaneous 254mg/kg (254mg/kg) Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 2169, 1993.
rat LD50 oral 650mg/kg (650mg/kg) Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5071, 1990.
mouse LD50 intravenous 98mg/kg (98mg/kg) Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 2169, 1993.
mouse LD50 oral 1023mg/kg (1023mg/kg) Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 2169, 1993.
rat LD50 subcutaneous 347mg/kg (347mg/kg) Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5071, 1990.
dog LD oral > 1gm/kg (1000mg/kg) Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5085, 1990.


  • (-)-(R)-5-(2-((2-(o-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide monohydrochloride (-)-LY 253352 (-)-ly253352
    (R)-(-)-YM12617;LY253351 (R)-5-(2-((2-(2-ETHOXYPHENOXY)ETHYL)AMINO)PROPYL)-2-METHOXYBENZENESULFONAMIDE HCL (R)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide hydrochloride
    (R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide monohydrochloride (R)-5-(2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-2 (R)-5-(2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-2-methoxybenzenesulfonamide hydrochloride
    106463-17-6 11SV1951MR 2-methoxy-5-[3,3,3-trideuterio-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]benzenesulfonamidehydrochloride
    463T176 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide;hydrochloride 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-benzenesulfonamide hydrochloride
    5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride 5-[(2R)-2-{[2-(2-Ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzene-1-sulfonamide--hydrogen chloride (1/1) 5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzenesulfonamide hydrochloride
    5-[(R)-2-[2-(2-Ethoxyphenoxy)ethylamino]propyl]]-2-methoxybenzenesulfonamide Hydrochloride A14936 AB0013408
    AK124398 AKOS015895342 AKOS015995287
    API0001417 Alna AlnaOCAS
    Amsulosin Hydrochloride;Tamsulosin hydrochloride Amsulosin hydrochloride BCP0726000042
    BG0475 BS-1019 Benzenesulfonamide, 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy-, monohydrochloride, (R)-
    Benzenesulfonamide, 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy-,monohydrochloride, (R)-; C20H28N2O5S.HCl C20H29ClN2O5S
    CAS-106463-17-6 CC-34638 CHEBI:9399
    CHEMBL1200914 CS-2897 Certified Reference Material
    D01024 DSSTox_CID_26628 DSSTox_GSID_46628
    DSSTox_RID_81777 DTXSID2046628 EU-617
    Expros FT-0631038 FT-0674803
    Flomax Flomax (TN) Flomax MR
    Flomax hydrochloride H991 HY-B0661A
    Harnal Harnal (TN) Harnalidge OCAS
    Josir KS-00000H3T LS-31577
    LY-253351 LY253351 MFCD00922997
    MLS003899197 MP-0769 NCGC00167442-01
    NCGC00167442-03 Omic Omix
    Omnic Pradif PubChem18241
    Q-201777 Q27108379 R-(-)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide hydrochloride
    R-(-)-YM-12617 RTX-011084 SC-17028
    SCHEMBL23428 SMR002543366 ST24026438
    Secotex TAMSULOSIN HYDROCHLORIDE Tamsulosin (hydrochloride)
    Tamsulosin HCl Tamsulosin Hydrochloride,(S) Tamsulosin hydrochloride (JP17/USAN)
    Tamsulosin hydrochloride [USAN:JAN] Tamsulosin hydrochloride [USAN:USP:JAN] Tamsulosin hydrochloride, >=98% (HPLC)
    Tamsulosin hydrochloride, British Pharmacopoeia (BP) Reference Standard Tamsulosin hydrochloride, European Pharmacopoeia (EP) Reference Standard Tamsulosin hydrochloride, Pharmaceutical Secondary Standard
    Tamsulosin hydrochloride, United States Pharmacopeia (USP) Reference Standard Tamsulosin-hydrochloride Tamsulosina hydrochloride
    Tamsulosinum hydrochloride Tox21_112446 Tox21_112446_1
    UNII-11SV1951MR Urolosin Y-617
    YM 617 YM-12617-1 YM-617
    YM617 ZZIZZTHXZRDOFM-XFULWGLBSA-N s4729
    tamsulosin.HCl tamsulosine hydrochloride

    CAS Number 106463-17-6, 128332-25-2, 80223-99-0
    PubChem Compound 5362376
    KEGG Drug D01024
    ChEBI 9399