Drug
D1111 | tenoxicam
M
M01AC02 Tenoxicam
[M01AC] Oxicams
[M01A] ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
[M01] ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
[M] Musculoskeletal system
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 8.36±1.07 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 6.6 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 4.23±3.79 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Danger |
Aggregated GHS information provided by 44 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 1 of 44 companies. For more detailed information, please visit ECHA C&L website Of the 4 notification(s) provided by 43 of 44 companies with hazard statement code(s): H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] H311 (93.02%): Toxic in contact with skin [Danger Acute toxicity, dermal] H331 (93.02%): Toxic if inhaled [Danger Acute toxicity, inhalation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| (3Z)-2-methyl-1,1-bis(oxidanylidene)-3-[oxidanyl-(pyridin-2-ylamino)methylidene]thieno[2,3-e][1,2]thiazin-4-one | (3Z)-3-[hydroxy-(2-pyridinylamino)methylidene]-2-methyl-1,1-dioxo-4-thieno[2,3-e]thiazinone | (3Z)-3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxothieno[2,3-e]thiazin-4-one |
| (4-hydroxy-2-methyl-1,1-dioxothiopheno[2,3-e]1,2-thiazin-3-yl)-N-(2-pyridyl)ca rboxamide | (Z)-3-(hydroxy(pyridin-2-ylamino)methylene)-2-methyl-2,3-dihydro-4H-thieno[2,3-e][1,2]thiazin-4-one 1,1-dioxide | 2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide |
| 2H-Thieno[2,3-e]-1,2-thiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide | 2H-Thieno[2,3-e]-1,2-thiazine-3-carboxamide,4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide | 3-[hydroxy(pyridin-2-ylamino)methylidene]-2-methyl-2,3-dihydro-4H-thieno[2,3-e][1,2]thiazin-4-one 1,1-dioxide |
| 4-HYDROXY-2-METHYL-N-2-PYRIDINYL-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXAMIDE 1,1-DIOXIDE | 4-Hydroxy-2-methyl-1,1-dioxo-N-(pyridin-2-yl)-1,2-dihydro-1lambda~6~-thieno[2,3-e][1,2]thiazine-3-carboxamide | 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide |
| 4-Hydroxy-2-methyl-N-2-pyridyl-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide | 4-Hydroxy-2-methyl-N-pyridin-2-yl-2H-thieno-[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide | 4-Hydroxy-2-methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide (Tenoxicam); |
| 4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide | 4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide | 4-hydroxy-2-methyl-n-pyridin-2-yl-2h-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide |
| 59804-37-4 | 804T374 | A832479 |
| AB00052322-11 | AB00052322_12 | AB00052322_13 |
| AB0012300 | AB2000615 | AC-4526 |
| AK481350 | AKOS000282084 | AKOS026750148 |
| Alganex | BBL028173 | BCBcMAP01_000251 |
| BCP03624 | BCP0726000170 | BDBM92332 |
| BG0331 | BIDD:GT0650 | BPBio1_000565 |
| BRN 0572193 | BSPBio_000513 | BSPBio_003066 |
| C-20248 | C13H11N3O4S2 | CAS-59804-37-4 |
| CCG-40126 | CCRIS 5264 | CHEBI:32192 |
| CHEMBL302795 | CHEMBL3188633 | CS-2546 |
| CTK7I2701 | D01767 | DB00469 |
| DSSTox_CID_25486 | DSSTox_GSID_45486 | DSSTox_RID_80909 |
| DTXSID8045486 | DivK1c_000252 | FT-0659572 |
| HMS1569J15 | HMS1923I15 | HMS2090P19 |
| HMS2092L20 | HMS2096J15 | HMS2232K23 |
| HMS3370L01 | HMS3656O10 | HMS3713J15 |
| HMS500M14 | HY-B0440 | IDI1_000252 |
| KBio1_000252 | KBio2_001910 | KBio2_004478 |
| KBio2_007046 | KBio3_002566 | KBioGR_001022 |
| KBioSS_001910 | KS-000010UB | KS-1313 |
| LS-152556 | LZNWYQJJBLGYLT-UHFFFAOYSA-N | Liman |
| MCULE-4636246417 | MFCD00083502 | MLS000069830 |
| MLS001074071 | MLS006011432 | Mobiflex |
| Mobiflex, Tenoxicam | N-(2-pyridyl)-4-hydroxy-2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide | NCGC00016889-01 |
| NCGC00016889-02 | NCGC00016889-03 | NCGC00016889-05 |
| NCGC00016889-06 | NCGC00095260-01 | NCGC00095260-02 |
| NINDS_000252 | NSC-758397 | NSC758397 |
| Octiveran | Opera_ID_1757 | Pharmakon1600-01503142 |
| Prestwick0_000527 | Prestwick1_000527 | Prestwick2_000527 |
| Prestwick3_000527 | Prestwick_849 | Q45050 |
| Q63395752 | Rexalgan | Ro 12-0068 |
| Ro 12-0068/000 | Ro-12-0068 | Ro-120068 |
| Ro-120068000 | SBB056362 | SBI-0051780.P002 |
| SC-13535 | SCHEMBL13448847 | SCHEMBL25343 |
| SCHEMBL25344 | SMP1_000040 | SMR000058865 |
| SPBio_001100 | SPBio_002434 | SPECTRUM1503142 |
| SR-01000721894 | SR-01000721894-2 | SR-01000721894-4 |
| ST50950119 | STK637103 | SW219788-1 |
| Spectrum2_001080 | Spectrum3_001563 | Spectrum4_000731 |
| Spectrum5_001615 | Spectrum_001430 | Tenoxicam (JAN/USAN/INN) |
| Tenoxicam [USAN:BAN:INN:JAN] | Tenoxicam [USAN:INN:BAN:JAN] | Tenoxicam(Mobiflex) |
| Tenoxicam, British Pharmacopoeia (BP) Reference Standard | Tenoxicam, European Pharmacopoeia (EP) Reference Standard | Tenoxicam, NSAID |
| Tenoxicamum | Tenoxicamum [INN-Latin] | Tenoxikam |
| Tilcotil | Tilcotil (TN) | Tox21_110666 |
| Tox21_110666_1 | UNII-Z1R9N0A399 | Z1R9N0A399 |
| ZINC100006429 | ZINC12503102 | ZINC40884328 |
| ZX-AT018824 | s2512 | tenoxicam |
| DrugBank | DB00469 |
| CAS Number | 59804-37-4 |
| PubChem Compound | 54677971 |
| KEGG Drug | D01767 |
| ChEBI | 32192 |
| PharmGKB | PA131890625 |