Compound

D1116 | tetrabutyltin

Molecular Formula C16H36Sn
Molecular Weight 347.2
Structure

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 5.66±1.03 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 11.22 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL rat hepatocytes MMP assay Negative IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 59 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H301 (74.58%): Toxic if swallowed [Danger Acute toxicity, oral]


H302 (20.34%): Harmful if swallowed [Warning Acute toxicity, oral]


H312 (74.58%): Harmful in contact with skin [Warning Acute toxicity, dermal]


H315 (93.22%): Causes skin irritation [Warning Skin corrosion/irritation]


H317 (16.95%): May cause an allergic skin reaction [Warning Sensitization, Skin]


H318 (18.64%): Causes serious eye damage [Danger Serious eye damage/eye irritation]


H319 (76.27%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H330 (16.95%): Fatal if inhaled [Danger Acute toxicity, inhalation]


H341 (11.86%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]


H360 (11.86%): May damage fertility or the unborn child [Danger Reproductive toxicity]


H372 (93.22%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


H400 (76.27%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410 (93.22%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P201, P202, P260, P261, P264, P270, P271, P272, P273, P280, P281, P284, P301+P310, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P312, P314, P320, P321, P322, P330, P332+P313, P333+P313, P337+P313, P362, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]


H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure


Narcotic effects]


H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


P201, P202, P260, P261, P264, P271, P281, P304+P340, P305+P351+P338, P308+P313, P312, P314, P337+P313, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
mouse LDLo intraperitoneal 174mg/kg (174mg/kg) Annales Pharmaceutiques Francaises. Vol. 14, Pg. 88, 1956.
rabbit LDLo oral > 5gm/kg (5000mg/kg) Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 15, Pg. 3, 1973.
rat LD50 intravenous 48mg/kg (48mg/kg) "Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 201, 1999.
mouse LD50 oral 6gm/kg (6000mg/kg) Journal of Pharmaceutical Sciences. Vol. 56, Pg. 240, 1967.
rabbit LDLo skin 2gm/kg (2000mg/kg) Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 15, Pg. 3, 1973.
rat LD50 subcutaneous 3082mg/kg (3082mg/kg) "Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 201, 1999.
mouse LC50 inhalation 142mg/m3 (142mg/m3) "Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 201, 1999.
mouse LDLo parenteral 347mg/kg (347mg/kg) peripheral nerve and sensation: flaccid paralysis without anesthesia (usually neuromuscular blockage) Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 239, Pg. 1091, 1954.
mouse LDLo intramuscular 1389mg/kg (1389mg/kg) Annales Pharmaceutiques Francaises. Vol. 14, Pg. 88, 1956.
rat LD50 oral 1268mg/kg (1268mg/kg) "Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 201, 1999.
mouse LD50 intravenous 56mg/kg (56mg/kg) U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02221,


  • (C4H9)4Sn 1461-25-2 7236AA
    ACMC-1C25D AFCAKJKUYFLYFK-UHFFFAOYSA-N AKOS016010486
    ANW-20987 BRN 3648237 Bu4Sn
    C16H36Sn CAS-1461-25-2 CCRIS 6322
    CTK0H9973 DSSTox_CID_2153 DSSTox_GSID_22153
    DSSTox_RID_76505 DTXSID4022153 EC 215-960-8
    EINECS 215-960-8 EN300-93667 HSDB 6074
    KSC179S7H LS-146607 MFCD00009422
    NCGC00164231-01 NCGC00256589-01 NCIOpen2_008184
    NSC 22330 NSC 28131 NSC 65524
    NSC-22330 NSC-28131 NSC-65524
    NSC22330 NSC28131 NSC65524
    Q425214; QJ7Y5V377V RTR-005780
    ST24031874 Stannane, tetrabutyl- TETRABUTYLTIN
    TR-005780 Terbutyltin 1000 microg/mL in Methanol Tetra-N-butylcin
    Tetra-N-butylcin [Czech] Tetra-Normal-Butyltin Tetra-n-butylcin [Czech]
    Tetra-n-butyltin Tetra-n-butyltin, 96% Tetrabutyl tin ion
    Tetrabutylstannane Tetrabutyltin 10 microg/mL in Cyclohexane Tetrabutyltin 100 microg/mL in Methanol
    Tetrabutyltin, technical grade, 93% Tin tetra-n-butyl Tin, tetrabutyl
    Tin, tetrabutyl- Tox21_302893 UNII-QJ7Y5V377V
    WLN: 4-SN-4&4&4 ZINC169743017 tetrabutyl tin

    CAS Number 1461-25-2, 358731-92-7
    PubChem Compound 15098