MITOTOX

Compound

D1121 | tetraoctylphosphonium bromide

Properties

Molecular Formula	C32H68BrP
Molecular Weight	563.8
Structure

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Species	Model	Method	Action	Positive criterion	Reference
MEMBRANE POTENTIAL	0.18±0.12	human	qHTS-HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	0.32	human	HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	6.82±2.23	rat	hepatocytes	MMP assay	decrease	IC50	163

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Danger	Aggregated GHS information provided by 55 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H314 (29.09%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] H315 (70.91%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (70.91%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (69.09%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H413 (27.27%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P260, P261, P264, P271, P273, P280, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Danger

Aggregated GHS information provided by 55 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H314 (29.09%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H315 (70.91%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (70.91%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335 (69.09%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure

Respiratory tract irritation]

H413 (27.27%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P260, P261, P264, P271, P273, P280, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

Synonyms Source: PubChem

23906-97-0	ACMC-209g6x	AKOS015833043
ANW-25255	AS-59832	CAS-23906-97-0
CHEMBL3182779	CTK4F2536	DSSTox_CID_27876
DSSTox_GSID_47900	DSSTox_RID_82629	DTXSID5047900
EINECS 245-935-7	J-015269;	KS-000015QV
NCGC00258130-01	Phosphonium,tetraoctyl-, bromide (1:1)	QVBRLOSUBRKEJW-UHFFFAOYSA-M
SCHEMBL125260	TR-011068	Tetra-n-octylphosphonium Bromide
Tetra-n-octylphosphoniumBromide	Tetraoctylphosphonium bromide	Tox21_200576
VZ33794	tetraoctylphosphanium bromide	tetraoctylphosphanium,bromide

External IDs

CAS Number	23906-97-0
PubChem Compound	3015167