Compound
D1128 | toluidine blue
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 3.48±1.60 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 4.89 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | rat | hepatocytes | MMP assay | Negative | IC50 | 163 | ||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Warning |
Aggregated GHS information provided by 7 companies from 2 notifications to the ECHA C&L Inventory. Reported as not meeting GHS hazard criteria by 6 of 7 companies. For more detailed information, please visit ECHA C&L website Of the 1 notification(s) provided by 1 of 7 companies with hazard statement code(s): H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P301+P312, P330, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| rabbit | LCLo | inhalation | 1400mg/m3/6H (1400mg/m3) | lungs, thorax, or respiration: other changes | National Technical Information Service. Vol. OTS0530684, |
| dog | LCLo | inhalation | 1400mg/m3/6H (1400mg/m3) | lungs, thorax, or respiration: other changes | National Technical Information Service. Vol. OTS0530684, |
| guinea pig | LCLo | inhalation | 1400mg/m3/6H (1400mg/m3) | lungs, thorax, or respiration: other changes | National Technical Information Service. Vol. OTS0530684, |
| guinea pig | LD50 | oral | 697mg/kg (697mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(2), Pg. 67, 1985. | |
| rabbit | LD50 | skin | 450uL/kg (0.45mL/kg) | American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969. | |
| rat | LD50 | oral | 500mg/kg (500mg/kg) | Weisheng Dulixue Zazhi. Journal of Health Toxicology. Vol. 6, Pg. 91, 1992. | |
| rat | LC50 | inhalation | 45ppm/4H (45ppm) | National Technical Information Service. Vol. OTS0546546, | |
| mouse | LD50 | oral | 390mg/kg (390mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(2), Pg. 67, 1985. | |
| (7-amino-8-methylbenzo[3,4-b]benzo[e]1,4-thiazin-3-yl)dimethylamine, chloride | (7-amino-8-methylphenothiazin-3-ylidene)dimethylamine, chloride | 15XUH0X66N |
| 3-Amino-7-(dimethylamino)-2-(methylphenazathionium) chloride | 3-Amino-7-dimethylamino-2-methylphenazathionium | 3-amino-7-(dimethylamino)-2-methylphenothiazin-5-ium chloride |
| 92-31-9 | AKOS015916405 | AKOS024282653 |
| Basic Blue 17 | Blutene | Blutene chloride |
| C.I. 52040 | C.I. 925 | C.I. Basic Blue 17 |
| C.I.BASIC BLUE 17 | C15H18N3S | CAS-92-31-9 |
| CCG-213755 | CCRIS 4933 | CHEBI:87647 |
| CHEMBL1790006 | CHEMBL562639 | CI-52040 |
| Chlorure de tolonium | Chlorure de tolonium [INN-French] | Cloruro de tolonio |
| Cloruro de tolonio [INN-Spanish] | DSSTox_CID_28654 | DSSTox_GSID_48728 |
| DSSTox_RID_82924 | DTXSID9048728 | Dimethyltoluthionine chloride |
| Dimethyltoluthionine chloride (VAN) | EINECS 202-146-2 | F Klot |
| FT-0690009 | FT-0724562 | GEDVVYWLPUPJJZ-UHFFFAOYSA-N |
| Gabilin | HMS1545F05 | HMS2752P23 |
| HMS3264B13 | HNONEKILPDHFOL-UHFFFAOYSA-M | Klot |
| LS-105696 | MCULE-6445743179 | MLS000738130 |
| Menodin | Modr Toluidinova | Modr Toluidinova [Czech] |
| Modr Zasadita 17 | Modr Zasadita 17 [Czech] | NCGC00181775-01 |
| NCGC00181775-02 | NSC 11225 | NSC-11225 |
| NSC-36758 | NSC-760421 | NSC11225 |
| NSC36758 | NSC760421 | Pharmakon1600-01506191 |
| Phenazathionium, 3-amino-7-(dimethylamino)-2-methyl-, chloride | Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride | Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride (1:1) |
| Q80868 | SBB057635 | SBB059304 |
| SCHEMBL122592 | SCHEMBL338335 | SR-01000760899 |
| SR-01000760899-2 | ST057360 | ST51006740 |
| Schultz 1041 | Schultz no. 1041 | T-3922 |
| TOLONIUM CHLORIDE | Tolazul | Toloni chloridum |
| Tolonii chloridum | Tolonii chloridum [INN-Latin] | Tolonium chloride [INN] |
| Toluidene Blue O Chloride | Toluidinblau | Toluidinblau [German] |
| Toluidine Blue | Toluidine Blue (C.I. 50240) | Toluidine Blue (phenothiazine dye) |
| Toluidine Blue 00 | Toluidine Blue O | Toluidine Blue O, 80% |
| Toluidine Blue O, 85% | Toluidine Blue O, Technical grade | Toluidine Blue O, certified by the Biological Stain Commission; |
| Toluidine Blue O, pure | Toluidine Blue OO | Toluidine Blue, phenothiazine dye |
| Tox21_113159 | Tox21_113159_1 | UNII-15XUH0X66N |
| WLN: T C666 BN ISJ E1 FZ LN1&1 &G | X6800 | n-(7-amino-8-methyl-3h-phenothiazin-3-ylidene)-n-methylmethanaminium chloride |