Compound

D1128 | toluidine blue

Molecular Formula C15H16ClN3S
Molecular Weight 305.8
Structure

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 3.48±1.60 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 4.89 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL rat hepatocytes MMP assay Negative IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 7 companies from 2 notifications to the ECHA C&L Inventory.


Reported as not meeting GHS hazard criteria by 6 of 7 companies. For more detailed information, please visit ECHA C&L website


Of the 1 notification(s) provided by 1 of 7 companies with hazard statement code(s):


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P264, P270, P301+P312, P330, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rabbit LCLo inhalation 1400mg/m3/6H (1400mg/m3) lungs, thorax, or respiration: other changes National Technical Information Service. Vol. OTS0530684,
dog LCLo inhalation 1400mg/m3/6H (1400mg/m3) lungs, thorax, or respiration: other changes National Technical Information Service. Vol. OTS0530684,
guinea pig LCLo inhalation 1400mg/m3/6H (1400mg/m3) lungs, thorax, or respiration: other changes National Technical Information Service. Vol. OTS0530684,
guinea pig LD50 oral 697mg/kg (697mg/kg) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(2), Pg. 67, 1985.
rabbit LD50 skin 450uL/kg (0.45mL/kg) American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rat LD50 oral 500mg/kg (500mg/kg) Weisheng Dulixue Zazhi. Journal of Health Toxicology. Vol. 6, Pg. 91, 1992.
rat LC50 inhalation 45ppm/4H (45ppm) National Technical Information Service. Vol. OTS0546546,
mouse LD50 oral 390mg/kg (390mg/kg) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(2), Pg. 67, 1985.


  • (7-amino-8-methylbenzo[3,4-b]benzo[e]1,4-thiazin-3-yl)dimethylamine, chloride (7-amino-8-methylphenothiazin-3-ylidene)dimethylamine, chloride 15XUH0X66N
    3-Amino-7-(dimethylamino)-2-(methylphenazathionium) chloride 3-Amino-7-dimethylamino-2-methylphenazathionium 3-amino-7-(dimethylamino)-2-methylphenothiazin-5-ium chloride
    92-31-9 AKOS015916405 AKOS024282653
    Basic Blue 17 Blutene Blutene chloride
    C.I. 52040 C.I. 925 C.I. Basic Blue 17
    C.I.BASIC BLUE 17 C15H18N3S CAS-92-31-9
    CCG-213755 CCRIS 4933 CHEBI:87647
    CHEMBL1790006 CHEMBL562639 CI-52040
    Chlorure de tolonium Chlorure de tolonium [INN-French] Cloruro de tolonio
    Cloruro de tolonio [INN-Spanish] DSSTox_CID_28654 DSSTox_GSID_48728
    DSSTox_RID_82924 DTXSID9048728 Dimethyltoluthionine chloride
    Dimethyltoluthionine chloride (VAN) EINECS 202-146-2 F Klot
    FT-0690009 FT-0724562 GEDVVYWLPUPJJZ-UHFFFAOYSA-N
    Gabilin HMS1545F05 HMS2752P23
    HMS3264B13 HNONEKILPDHFOL-UHFFFAOYSA-M Klot
    LS-105696 MCULE-6445743179 MLS000738130
    Menodin Modr Toluidinova Modr Toluidinova [Czech]
    Modr Zasadita 17 Modr Zasadita 17 [Czech] NCGC00181775-01
    NCGC00181775-02 NSC 11225 NSC-11225
    NSC-36758 NSC-760421 NSC11225
    NSC36758 NSC760421 Pharmakon1600-01506191
    Phenazathionium, 3-amino-7-(dimethylamino)-2-methyl-, chloride Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride (1:1)
    Q80868 SBB057635 SBB059304
    SCHEMBL122592 SCHEMBL338335 SR-01000760899
    SR-01000760899-2 ST057360 ST51006740
    Schultz 1041 Schultz no. 1041 T-3922
    TOLONIUM CHLORIDE Tolazul Toloni chloridum
    Tolonii chloridum Tolonii chloridum [INN-Latin] Tolonium chloride [INN]
    Toluidene Blue O Chloride Toluidinblau Toluidinblau [German]
    Toluidine Blue Toluidine Blue (C.I. 50240) Toluidine Blue (phenothiazine dye)
    Toluidine Blue 00 Toluidine Blue O Toluidine Blue O, 80%
    Toluidine Blue O, 85% Toluidine Blue O, Technical grade Toluidine Blue O, certified by the Biological Stain Commission;
    Toluidine Blue O, pure Toluidine Blue OO Toluidine Blue, phenothiazine dye
    Tox21_113159 Tox21_113159_1 UNII-15XUH0X66N
    WLN: T C666 BN ISJ E1 FZ LN1&1 &G X6800 n-(7-amino-8-methyl-3h-phenothiazin-3-ylidene)-n-methylmethanaminium chloride

    CAS Number 92-31-9, 98104-93-9
    PubChem Compound 7083
    ChEBI 87647