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Drug

D1139 | triclocarban

Molecular Formula C13H9Cl3N2O
Molecular Weight 315.6
Structure
State solid
Clearance After a pharmacokinetic study in man, radioactivity was rapidly cleared from blood after intravenous administrations of (14)C-triclocarban in propylene glycol with a blood clearance half-life measured to be 8.6 hours [L2685].
Route of elimination The metabolism of (14)C-TCC (3,4,4'-trichlorocarbanilide) has been investigated in humans following oral exposure to 2.2 mumol/kg. Fecal elimination (70% of dose) was complete at the 120 hour point after administration and the urinary excretion (27% of dose) was complete after 80 hours post-administration [L2685]. Urinary glucuronides appear to be valuable biomarkers of triclocarban exposure [A32932].
Half life 10 hours [L2680]
Absorption A human exposure study in a small group of subjects demonstrated that a portion of the TCC present in bar soaps is absorbed through the skin and is excreted in urine as N-glucuronides [A32932]. Because they are produced and used in large quantities in various products, they are absorbed into the human body of the general population [L2679]. The absorption of triclocarban during a human pharmacokinetic study was estimated at 0.6% of the 70 + or - 15 mg of triclocarban in the soap used. The triclocarban-N-glucuronide urine concentration varied considerably among the study subjects, and continuous daily use of the soap led to steady-state levels of excretion [L2685].

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 0.14±0.05 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 0.17 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 0.17±0.10 rat hepatocytes MMP assay decrease IC50 163

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 180 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H400 (96.67%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P273, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


 P273, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rabbit LD50 skin > 7940ug/kg (7.94mg/kg) National Technical Information Service. Vol. OTS0524327-1,
mouse LD50 intraperitoneal 2100mg/kg (2100mg/kg) Labo-Pharma-Problemes et Techniques. Vol. 27, Pg. 306, 1979.
rat LD50 oral > 34600mg/kg (34600mg/kg) Toxicology and Applied Pharmacology. Vol. 33, Pg. 171, 1975.


  • 1-(3',4'-Dichlorophenyl)-3-(4'-chlorophenyl)urea 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea 101-20-2
    3,4'-Trichlorocarbanilide 3,4'-Trichlorodiphenylurea 3,4,4'-TRICHLOROCARBANILIDE
    3,4,4'-Trichlorocarbanilide, 99% 3,4,4'-Trichlorodiphenylurea 3,4,4'-trichloro carbanilide
    3,4,4-Trichlorocarbanilide 3,4,4` Trichlorocarbanilide (Triclocarban), Pharmaceutical Secondary Standard 3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea
    4-12-00-01265 (Beilstein Handbook Reference) 9EG AC-12602
    AI3-26925 AK163703 AKOS001713711
    AX8081482 BDBM25730 BGG1Y1ED0Y
    BRN 2814890 C-49798 C13H9Cl3N2O
    CAS-101-20-2 CCRIS 4880 CHEBI:48347
    CHEMBL1076347 CP 78416 CS-7760
    CTK7G5073 Carbanilide, 3,4,4'-trichloro- Carbanilide,4,4'-trichloro-
    Caswell No. 874 Certified Reference Material; Cusiter
    Cutisan D06223 DB11155
    DSSTox_CID_6214 DSSTox_GSID_26214 DSSTox_RID_78062
    DTXSID4026214 EC 202-924-1 EINECS 202-924-1
    ENT 26925 EPA Pesticide Chemical Code 027901 FT-0614114
    Genoface HSDB 5009 HY-B1805
    ICUTUKXCWQYESQ-UHFFFAOYSA-N J10256 KS-000000YY
    KS-5290 LS-328 MCULE-7925567906
    MFCD00013254 MLS002415563 N-(3,4-Dichlorophenyl)-N'-(4-chlorophenyl)urea
    N-(4-Chlorophenyl)-N'-(3,4-dichlorophenyl)urea N-(4-Chlorophenyl)-N-(3,4-dichlorophenyl)-Urea N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)-urea
    NCGC00164034-01 NCGC00164034-02 NCGC00164034-03
    NCGC00164034-04 NCGC00164034-05 NCGC00254243-01
    NCGC00259579-01 NCIOpen2_008923 NSC 72005
    NSC-72005 NSC72005 Nipaguard TCC
    Procutene Q-201865 Q416579
    SCHEMBL68658 SMR001339078 SR-01000860289
    SR-01000860289-2 ST011927 ST24037341
    STK730440 Septivon-Lavril Solubacter
    TCC TCC (soap bacteriostat) TCC Soap
    TR-000339 TRA0036036 Tox21_112078
    Tox21_112078_1 Tox21_202030 Tox21_300481
    Trichlocarban Trichlorocarbanilide Triclocarban
    Triclocarban (USAN/INN) Triclocarban [USAN:INN] Triclocarban, United States Pharmacopeia (USP) Reference Standard
    Triclocarban, analytical standard Triclocarbanum Triclocarbanum [INN-Latin]
    Trilocarban UNII-BGG1Y1ED0Y US8815951, 3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea
    Urea, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)- Urea,4-dichlorophenyl)- Urea-based compound, 11
    WLN: GR DMVMR CG DG ZINC121480 [(3,4-dichlorophenyl)amino]-N-(4-chlorophenyl)carboxamide
    cid_7547 s6444 trichlorcarban

    DrugBank DB11155
    CAS Number 101-20-2
    PubChem Compound 7547
    KEGG Drug D06223
    ChEBI 48347