MITOTOX

Compound

D1144 | trihexyltetradecylphosphonium bromide

Properties

Molecular Formula	C32H68BrP
Molecular Weight	563.8
Structure

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Species	Model	Method	Action	Positive criterion	Reference
MEMBRANE POTENTIAL	0.84±0.24	human	qHTS-HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	0.45	human	HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	18.82±4.25	rat	hepatocytes	MMP assay	decrease	IC50	163

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Warning	Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H315 (97.44%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (97.44%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (97.44%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Warning

Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H315 (97.44%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (97.44%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335 (97.44%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure

Respiratory tract irritation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

Synonyms Source: PubChem

654057-97-3	AS-63459	CAS-654057-97-3
CHEMBL3185205	CTK1J7023	DSSTox_CID_27929
DSSTox_GSID_47953	DSSTox_RID_82682	DTXSID0047953
NCGC00258363-01	Phosphonium, trihexyltetradecyl-, bromide	RT-016122
SCHEMBL305729	TRIHEXYL(TETRADECYL)PHOSPHANIUM BROMIDE;	Tetradecyltrihexylphosphonium bromide
Tox21_200809	Trihexyltetradecylphosphonium bromide	Trihexyltetradecylphosphonium bromide, >=95%
trihexyl(tetradecyl)phosphonium bromide

External IDs

CAS Number	654057-97-3
PubChem Compound	16218822