MITOTOX

Compound

D1145 | trihexyltetradecylphosphonium chloride

Properties

Molecular Formula	C32H68ClP
Molecular Weight	519.3
Structure

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Species	Model	Method	Action	Positive criterion	Reference
MEMBRANE POTENTIAL	0.77±0.35	human	qHTS-HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	0.89	human	HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	30.31±8.97	rat	hepatocytes	MMP assay	decrease	IC50	163

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Danger	Aggregated GHS information provided by 56 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] H317 (28.57%): May cause an allergic skin reaction [Warning Sensitization, Skin] H318 (30.36%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H400 (30.36%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (30.36%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P260, P261, P264, P270, P272, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P333+P313, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Danger

Aggregated GHS information provided by 56 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H317 (28.57%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H318 (30.36%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H400 (30.36%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (30.36%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P260, P261, P264, P270, P272, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P333+P313, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

Synonyms Source: PubChem

258864-54-9	CAS-258864-54-9	CHEMBL3186883
CTK8E6488	DSSTox_CID_27920	DSSTox_GSID_47944
DSSTox_RID_82673	DTXSID1047944	JCQGIZYNVAZYOH-UHFFFAOYSA-M
KS-000018SG	NCGC00258251-01	Phosphonium, trihexyltetradecyl-, chloride
RT-016123	SCHEMBL245448	TETRADECYL(TRIHEXYL)PHOSPHONIUM CHLORIDE
Tox21_200697	Trihexyltetradecylphosphonium chloride	Trihexyltetradecylphosphonium chloride, >=95.0% (NMR);
trihexyl(tetradecyl) phosphonium chloride	trihexyl(tetradecyl)phosphanium,chloride

External IDs

CAS Number	258864-54-9
PubChem Compound	11375816