MITOTOX

Compound

D1146 | trihexyltetradecylphosphonium dicyanamide

Properties

Molecular Formula	C34H68N3P
Molecular Weight	549.9
Structure

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Species	Model	Method	Action	Positive criterion	Reference
MEMBRANE POTENTIAL	0.39±0.19	human	qHTS-HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	0.89	human	HepG2	MMP assay	decrease	IC50	163
MEMBRANE POTENTIAL	31.02±11.67	rat	hepatocytes	MMP assay	decrease	IC50	163

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Danger	Aggregated GHS information provided by 54 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302 (27.78%): Harmful if swallowed [Warning Acute toxicity, oral] H314 (74.07%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] H315 (25.93%): Causes skin irritation [Warning Skin corrosion/irritation] H318 (27.78%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H400 (27.78%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (27.78%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P260, P264, P270, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P332+P313, P362, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Danger

Aggregated GHS information provided by 54 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H302 (27.78%): Harmful if swallowed [Warning Acute toxicity, oral]

H314 (74.07%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H315 (25.93%): Causes skin irritation [Warning Skin corrosion/irritation]

H318 (27.78%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H400 (27.78%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (27.78%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P260, P264, P270, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P332+P313, P362, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

Synonyms Source: PubChem

701921-71-3	CAS-701921-71-3	CHEMBL3188352
CTK2H6421	DSSTox_CID_29310	DSSTox_GSID_49351
DSSTox_RID_83426	DTXSID6049351	NCGC00260161-01
RT-016125	SCHEMBL2091311	T3534
Tox21_202613	Trihexyltetradecylphosphonium dicyanamide	Trihexyltetradecylphosphonium dicyanamide, >=95%;

External IDs

CAS Number	701921-71-3
PubChem Compound	16217238