Search References Drug Actions/Targets About Access data Feedback
Sign In
mitontu@gmail.com
2021 MitoTox | (CC BY-NC 4.0)
Drug

D1157 | zafirlukast

Molecular Formula C31H33N3O6S
Molecular Weight 575.7
Structure
State solid
Clearance * apparent oral CL=20 L/h * 11.4 L/h [7-11 yrs] * 9.2 L/h [5-6 yrs]
Volume of distribution * 70 L
Route of elimination The most common metabolic products are hydroxylated metabolites which are excreted in the feces.
Protein binding 0.99
Half life 10 hours
Absorption Rapidly absorbed following oral administration, reduced following a high-fat or high-protein meal.

R

R03DC01 Zafirlukast


[R03DC] Leukotriene receptor antagonists


[R03D] OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES


[R03] DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES


[R] Respiratory system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 10.59±1.22 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 13.77 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 3.43±1.47 rat hepatocytes MMP assay decrease IC50 163

Pictogram Signal Statements Precautionary Statement Codes

Aggregated GHS information provided by 41 companies from 2 notifications to the ECHA C&L Inventory.


H413 (92.68%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P273, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • 107753-78-6 32256-EP2270008A1 32256-EP2280006A1
    32256-EP2281813A1 32256-EP2281815A1 32256-EP2281819A1
    32256-EP2284166A1 32256-EP2292617A1 32256-EP2292619A1
    32256-EP2295409A1 32256-EP2298415A1 32256-EP2301933A1
    32256-EP2305640A2 32256-EP2305659A1 32256-EP2308562A2
    32256-EP2311818A1 32256-EP2311827A1 4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide
    4-(5-cyclopentyloxycarbonylamino-2-methylindol-3-yl-methyl)-3-methoxy-N-O-tolylsulfonylbenzamide 4CH-018070 753Z786
    A801752 AB0012638 AB00639922-06
    AB00639922-08 AB00639922_09 AB2000178
    AC-9018 ACMC-209wlw AKOS005577888
    ANW-46530 AS-12943 Accolate
    Accolate (TN) Accolate;Accoleit;Vanticon Accoleit
    Aeronix BCP05226 BDBM50009073
    BG0591 BG0649 BIDD:GT0267
    BR-72849 BRD-K71289571-001-06-4 C-23263
    C07206 C31H33N3O6S CAS-107753-78-6
    CC-35662 CCG-101025 CHEBI:10100
    CHEMBL603 CPD000466316 CS-2167
    CTK4A5698 Carbamic acid, (3-((2-methoxy-4-((((2-methylphenyl)sulfonyl)amino)carbonyl)phenyl)methyl)-1-methyl-1H-indol-5-yl)-, cyclopentyl ester Cyclopentyl (3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methyl-1H-indol-5-yl)carbamate
    Cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamate Cyclopentyl N-[3-[[2-Methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-1H-indol-5-yl]carbamate D00411
    DB00549 DSSTox_CID_3746 DSSTox_GSID_23746
    DSSTox_RID_77181 DTXSID5023746 FT-0601575
    GP6218 GTPL3322 HMS2051F12
    HMS2089J10 HMS3393F12 HMS3650A04
    HMS3655E13 HMS3713J08 HMS3745K03
    HY-17492 ICI 204,219 ICI 204219
    ICI-204219 KS-00001D9L L001011
    LS-50025 MCULE-2053856450 MFCD00864775
    MLS000759421 MLS000759421-02 MLS001424064
    MLS006011771 N-[3-[[2-Methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-1H-indol-5-yl]carbamic Acid Cyclopentyl Ester N-[3-[[2-methoxy-4-[[(2-methylphenyl)sulfonylamino]-oxomethyl]phenyl]methyl]-1-methyl-5-indolyl]carbamic acid cyclopentyl ester
    NC00275 NCGC00164547-01 NCGC00164547-02
    NCGC00164547-03 NCGC00164547-04 NCGC00164547-05
    NCGC00164547-06 Olmoran PubChem18223
    Q-201940 Q928378 RTR-001857
    Respix SAM001246577 SB19079
    SC-45160 SCHEMBL4175 SMR000466316
    SR-01000759386 SR-01000759386-4 SR-01000759386-5
    SR-01000759386-9 ST2406760 STK646780
    SW197655-3 TR-001857 Tox21_112176
    Tox21_112176_1 UNII-XZ629S5L50 Vanticon
    XZ629S5L50 YEEZWCHGZNKEEK-UHFFFAOYSA-N Z1551429730
    ZINC000000896717 ZINC896717 ZLK;
    Zafirlukast (Accolate) Zafirlukast (JAN/USAN/INN) Zafirlukast [USAN:BAN:INN]
    Zafirlukast [USAN:INN:BAN] Zafirlukast(Accolate) Zafirlukast, >=98% (HPLC)
    Zafirst cc-92 cyclopentyl (1-methyl-3-{[2-(methyloxy)-4-({[(2-methylphenyl)sulfonyl]amino}carbonyl)phenyl]methyl}-1H-indol-5-yl)carbamate
    cyclopentyl 3-(2-methoxy-4-(o-tolylsulfonylcarbamoyl)benzyl)-1-methyl-1H-indol-5-ylcarbamate cyclopentyl 3-[2-methoxy-4-(2-methylphenylsulfonylcarbamoyl)benzyl]-1-methyl-1H-indol-5-ylcarbamate cyclopentyl N-[3-({2-methoxy-4-[(2-methylbenzenesulfonyl)carbamoyl]phenyl}methyl)-1-methyl-1H-indol-5-yl]carbamate
    cyclopentyl N-[3-[[2-methoxy-4-(o-tolylsulfonylcarbamoyl)phenyl]methyl]-1-methyl-indol-5-yl]carbamate cyclopentyl N-[3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methyl-indol-5-yl]carbamate cyclopentyl N-{3-[(2-methoxy-4-{[(2-methylbenzene)sulfonyl]carbamoyl}phenyl)methyl]-1-methyl-1H-indol-5-yl}carbamate
    cyclopentyl [3-(2-methoxy-4-{[(2-methylphenyl)sulfonyl]carbamoyl}benzyl)-1-methyl-1H-indol-5-yl]carbamate s1633 zafirlukast

    DrugBank DB00549
    CAS Number 107753-78-6
    PubChem Compound 5717
    KEGG Compound ID C07206
    KEGG Drug D00411
    ChEBI 10100
    PharmGKB PA451949