MITOTOX

Compound

D1266 | apoptolidin

Properties

Molecular Formula	C58H96O21
Molecular Weight	1129.4
Structure
Description	macrolides (a class of antibiotics); originally produced by Nocardiopsis species; selective cytotoxic agent; polyketide inhibitors of F0F1-ATPase

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
ELECTRON TRANSPORT CHAIN	4-5 μM		S. cerevisiae	membrane-bound F0F1-ATPase		decrease	Ki	161
ELECTRON TRANSPORT CHAIN	18 μM		human	NCI-60 cell lines, F0F1-ATPase		decrease	IC50	154
APOPTOSIS	18 μM			60 human cancer cell lines of the National Cancer Institute			mean	184

Targets

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
ATP synthase	4-5 μM		S. cerevisiae	membrane-bound F0F1-ATPase		inhibitor	Ki	161
ATP synthase	18 μM		human	NCI-60 cell lines, F0F1-ATPase		inhibitor	IC50	154

Indications Source: SIDER

Synonyms Source: PubChem

Apoptolidin	CHEMBL4096158	FU-40A
Q27289111	SAO6WVQ23I	UNII-SAO6WVQ23I

External IDs

CAS Number	194874-06-1
PubChem Compound	11297771
ChemSpider	58824353

References