MITOTOX

Compound

D1267 | cytovaricin

Properties

Molecular Formula	C47H80O16
Molecular Weight	901.1
Structure
Description	polyketide inhibitors of F0F1-ATPase,

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
ELECTRON TRANSPORT CHAIN	1 μM		human	NCI-60 cell lines, F0F1-ATPase		decrease	IC50	154
ELECTRON TRANSPORT CHAIN	0.4 μM		S. cerevisiae	membrane-bound F0F1-ATPase		decrease	Ki	161
APOPTOSIS	1 μM			60 human cancer cell lines of the National Cancer Institute			mean	184

Targets

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
ATP synthase	1 μM		human	NCI-60 cell lines, F0F1-ATPase		inhibitor	IC50	154
ATP synthase	0.4 μM		S. cerevisiae	membrane-bound F0F1-ATPase		inhibitor	Ki	161

Acute Effects Source: ChemIDplus

Organism	Test type	Route	Dose (normalized dose)	Effect	Source
mouse	LDLo	intraperitoneal	3130ug/kg (3.13mg/kg)		Journal of Antibiotics. Vol. 34, Pg. 1073, 1981.

Indications Source: SIDER

Synonyms Source: PubChem

79553-45-0	BRN 4226438	Cytovaricin
H-230	LS-59152	NSC 349622

External IDs

CAS Number	79553-45-0
PubChem Compound	6436235
ChemSpider	4940885

References