MITOTOX

Compound

D1301 | toxoflavin

Properties

Molecular Formula	C7H7N5O2
Molecular Weight	193.16
Structure
Description	a toxin produced by a variety of bacteria including Burkholderia gladioli; antibiotic properties; quinoidal-type structural classes

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
NONPROTONOPHORIC UNCOUPLERS			rat	liver mitochondria	RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1	increase		204

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Danger	Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P264, P270, P301+P310, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Danger

Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P264, P270, P301+P310, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Acute Effects Source: ChemIDplus

Organism	Test type	Route	Dose (normalized dose)	Source
mouse	LDLo	intraperitoneal	3mg/kg (3mg/kg)	Journal of Organic Chemistry. Vol. 31, Pg. 900, 1966.
mouse	LD50	intravenous	1700ug/kg (1.7mg/kg)	Antibiotics and Chemotherapy Vol. 4, Pg. 259, 1954.
mouse	LD50	oral	8400ug/kg (8.4mg/kg)	Antibiotics and Chemotherapy Vol. 4, Pg. 259, 1954.

Indications Source: SIDER

External IDs

CAS Number	84-82-2
PubChem Compound	66541