MITOTOX

Drug

D1328 | Mersalyl

Properties

Molecular Formula	C13H18HgNO6
Molecular Weight	484.88
Structure
State	solid
Clearance	The hepatobiliary excretion of mersayl was studied in the isolated perfused rat liver and in isolated rat liver plasma membrane vesicles. In the isolated perfused liver, mersalyl was found to be immediately absorbed by the perfusion medium and concentratively excreted into bile. Uptake is characterized by saturation kinetics (S)0.5 = 20 microM, Vmax = 117 nmoles/min/g liver, cooperatively of mersalyl binding sites, stimulation by extracellular sodium and temperature dependence. Uptake of mersalyl into basolateral membrane vesicles also demonstrates characteristics of a carrier-mediated transport, dependence on extravesicular sodium, cooperativity of mersalyl binding sites, temperature dependence and trans-stimulation by intravesicular non-radioactive mersalyl. Uptake was found to be inhibited by alpha-naphthylacetic acid and mercapto group reagents, suggesting involvement of mercapto groups on the carrier and a binding site for carboxylic anions. Data from the isolated perfused liver and from isolated basolateral vesicles suggest that mersalyl uptake into the liver is carrier mediated. Uptake mechanism and driving forces appear analogous to those for the uptake of chemically related compounds such as taurocholic acid. It is, therefore, speculated that mersalyl may be transported by carrier molecules which accept various chemically unrelated compounds [L1584].
Route of elimination	Organic mercury is metabolized into inorganic mercury, which is eventually excreted in the urine and feces [L1582].
Description	Thiol group reagents

Therapeutic Classification Source: DrugBank

C03BC01 Mersalyl

[C03BC] Mercurial diuretics

[C03B] LOW-CEILING DIURETICS, EXCL. THIAZIDES

[C03] DIURETICS

[C] Cardiovascular system

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
PROTON CONDUCTIVITY	130 μM		bovine	heart MF0, proton conductivity		affect	70% inhibition	170

Targets

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
Fo subunits	130 μM		bovine	heart MF0, proton conductivity		inhibitor	70% inhibition	170
Phosphate carrier protein, mitochondrial						inhibitor		230

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Danger	Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral] H310 (100%): Fatal in contact with skin [Danger Acute toxicity, dermal] H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation] H373 (100%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P260, P262, P264, P270, P271, P273, P280, P284, P301+P310, P302+P350, P304+P340, P310, P314, P320, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Danger

Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]

H310 (100%): Fatal in contact with skin [Danger Acute toxicity, dermal]

H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]

H373 (100%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P260, P262, P264, P270, P271, P273, P280, P284, P301+P310, P302+P350, P304+P340, P310, P314, P320, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

Synonyms Source: PubChem

(3-(2-(carboxymethoxy)benzamido)-2-methoxypropyl)(hydroxy)mercury	486-67-9	ACM486679
API0003303	C-33804	C11336
CAS-486-67-9	CHEBI:6771	DB09338
DSSTox_CID_26902	DSSTox_GSID_46902	DSSTox_RID_82001
DTXSID3046902	GTPL5331	Mercurate(1-), [3-[[2-(carboxylatomethoxy)benzoyl]amino]-2-methoxypropyl]hydroxy-, hydrogen
Mersal	Mersalyl	Mersalyl acid
Mersalyl acid, analytical standard	NCGC00181320-01	Q424871
SCHEMBL993248	Tox21_112788

External IDs

DrugBank	DB09338
CAS Number	486-67-9
PubChem Compound	443130