Compound

D1343 | Maneb

Molecular Formula C4H6MnN2S4
Molecular Weight 265.3
Structure
Description fungicide; a polymeric complex of manganese with the ethylene bis(dithiocarbamate) anionic ligand

Target Dose Time Species Model Method Action Positive criterion Reference
Quinol--cytochrome-c reductase 30 mg/kg i.p. twice a week/6 weeks C57BL/6 mice inhibit 242

Pictogram Signal Statements Precautionary Statement Codes
Warning

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H361d ***: Suspected of damaging the unborn child [Warning Reproductive toxicity]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


P201, P202, P261, P272, P273, P280, P281, P302+P352, P308+P313, P321, P333+P313, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H332: Harmful if inhaled [Warning Acute toxicity, inhalation]


H361d ***: Suspected of damaging the unborn child [Warning Reproductive toxicity]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P201, P202, P261, P264, P271, P272, P273, P280, P281, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P321, P333+P313, P337+P313, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

Aggregated GHS information provided by 536 companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]


H361 (99.25%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


H400 (99.25%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P201, P202, P261, P272, P273, P280, P281, P302+P352, P308+P313, P321, P333+P313, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

Aggregated GHS information provided by 209 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]


H319 (98.56%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H332 (98.56%): Harmful if inhaled [Warning Acute toxicity, inhalation]


H361 (98.56%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


H400 (98.56%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410 (98.56%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P201, P202, P261, P264, P271, P272, P273, P280, P281, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P321, P333+P313, P337+P313, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H361d: Suspected of damaging the unborn child [Warning Reproductive toxicity]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


P201, P202, P261, P272, P273, P280, P281, P302+P352, P308+P313, P321, P333+P313, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H332: Harmful if inhaled [Warning Acute toxicity, inhalation]


H361d: Suspected of damaging the unborn child [Warning Reproductive toxicity]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P201, P202, P261, P264, P271, P272, P273, P280, P281, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P321, P333+P313, P337+P313, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H252: Self-heating in large quantities


may catch fire [Warning Self-heating substances and mixtures]


H261: In contact with water releases flammable gas [Danger Substances and mixtures which in contact with water, emit flammable gases]


H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H351: Suspected of causing cancer [Warning Carcinogenicity]


H360: May damage fertility or the unborn child [Danger Reproductive toxicity]


H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P201, P202, P231+P232, P235+P410, P260, P261, P264, P270, P272, P273, P280, P281, P302+P352, P305+P351+P338, P308+P313, P314, P321, P333+P313, P337+P313, P363, P370+P378, P391, P402+P404, P405, P407, P413, P420, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H320: Causes eye irritation [Warning Serious eye damage/eye irritation]


H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


P260, P261, P264, P272, P280, P302+P352, P305+P351+P338, P314, P321, P333+P313, P337+P313, P363, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

H252: Self-heating in large quantities


may catch fire [Warning Self-heating substances and mixtures]


H261: In contact with water releases flammable gas [Danger Substances and mixtures which in contact with water, emit flammable gases]


H316: Causes mild skin irritation [Warning Skin corrosion/irritation]


H317: May cause an allergic skin reaction [Warning Sensitization, Skin]


H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H333: May be harmful if inhaled [Warning Acute toxicity, inhalation]


H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


P231+P232, P235+P410, P260, P261, P264, P271, P272, P280, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P314, P321, P332+P313, P333+P313, P337+P313, P363, P370+P378, P402+P404, P407, P413, P420, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
guinea pig LDLo oral 6400mg/kg (6400mg/kg) Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 675, 1966.
rat LD50 skin > 5gm/kg (5000mg/kg) "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A252, Pg. 1983,
rat LD50 unreported 3gm/kg (3000mg/kg) Environmental Quality and Safety, Supplement. Vol. 3, Pg. 618, 1975.
rat LD50 oral 3gm/kg (3000mg/kg) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 36(5), Pg. 22, 1971.
quail LD50 unreported 467mg/kg (467mg/kg) Farm Chemicals Handbook. Vol. -, Pg. C189, 1991.
mammal (species unspecified) LD50 unreported 5gm/kg (5000mg/kg) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(5), Pg. 29, 1980.
mouse LD50 oral 2600mg/kg (2600mg/kg) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 36(5), Pg. 22, 1971.


  • 1,2-Ethanediylbis(carbamodithioato)(2-)-manganese 1,2-Ethanediylbiscarbamodithioic acid, manganese complex 1,2-Ethanediylbiscarbamodithioic acid, manganese(2+) salt (1:1)
    1,2-Ethanediylbismaneb, manganese(2+) salt (1:1) 1,2-Ethylenediylbis(carbamodithioato)manganese 12427-38-2
    301-03-1 8018-01-7 88535-EP2298077A1
    88535-EP2301353A1 88535-EP2305031A1 88535-EP2305035A1
    AAmangan AI3-14875 Agrox N-M
    Agrox flowable Akzo chemie maneb BASF-maneb spritzpulver
    CAS-12427-38-2 CCRIS 1107 CR 3029
    Carbamic acid, ethylenebis(dithio-, manganese salt Carbamodithioic acid, 1,2-ethanediylbis-, manganese(2+) salt (1:1) Caswell No. 539
    Chem neb Chloroble M Curzate M
    DB-041771 DSSTox_CID_794 DSSTox_GSID_20794
    DSSTox_RID_75793 DTXSID9020794 Dithane M 22
    Dithane M 22 special EINECS 235-654-8 ENT 14,875
    EPA Pesticide Chemical Code 014505 Ethylenebis(dithiocarbamato), manganese Ethylenebis(dithiocarbamato)manganese
    Ethylenebis(dithiocarbamic acid) manganous salt Ethylenebisdithiocarbamate manganese F 10 (Pesticide)
    Farmaneb Granol NM Griffin manex
    HSDB 4063 K221E12G7T Kypman 80
    LS-7478 Lonocol M Luxan maneb 80
    M-Diphar MANEB Maneb 80
    Maneb ZL4 Maneb [BSI:ISO] Maneb or maneb preparations with not <60% maneb [UN2210] [Spontaneously combustible]
    Maneb or maneb preparations, stabilized against self-heating Maneb or maneb preparations, with not <60% maneb Maneb stabilized or Maneb preparations, stabilized against self-heating [UN2968] [Dangerous when wet]
    Maneb-R Maneba Manebe 80
    Manebe [French] Manebe [ISO-French] Manebgan
    Manesan Manex Mangaan(II)-(N,N'-ethyleen-bis(dithiocarbamaat)) [Dutch]
    Mangan(II)-(N,N-aethylen-bis(dithiocarbamat)) [German] Manganese ethylene-1,2-bis-dithiocarbamate Manganese ethylene-1,2-bisdithiocarbamate
    Manganese ethylene-1,2-bisdithiocarbamate, polymer Manganese ethylenebis(dithiocarbamate) (polymeric) Manganese ethylenebisthiocarbamate
    Manganese(2+) ethane-1,2-diyldicarbamodithioate Manganese(II) ethylene di(dithiocarbamate) Manganese, ((1,2-ethanediylbis(carbamodithioato))(2-))-
    Manganese, ((2-((dithiocarboxy)amino)ethyl)carbamodithioato(2-)-kappaS,kappaS')- Manganese, (ethylenebis(dithiocarbamato))- Manganese, [[2-[(dithiocarboxy)amino]ethyl]carbamodithioato(2-)-.kappa.S,.kappa.S']-
    Manganeseethylene-bis-dithiocarbamate Manganous ethylenebis(dithiocarbamate) Manzate
    Manzate D Manzate maneb fungicide MnEBD
    N,N'-Ethylene bis(dithiocarbamate manganeux) [French] N,N'-Etilen-bis(ditiocarbammato) di manganese [Italian] NCGC00163729-03
    NCGC00163729-04 NCGC00254730-01 Nereb
    Nespor Plantifog 160M Polyram M
    Q409156 Remasan chloroble M Rhodianebe
    SCHEMBL20721 Sopranebe Tersan LSR
    Tox21_300826 Trimangol 80 Tubothane
    UN2210 UN2968 UNII-K221E12G7T
    UNII-YZV3TC1UNI component YKSNLCVSTHTHJA-UHFFFAOYSA-L Unicrop maneb Vancide Maneb 90
    Vancide maneb 80 [ethane-1,2-diylbiscarbamodithioato(2-)-kappaS]manganese [{2-[(sulfanylcarbothioyl)amino]ethyl}carbamodithioato(2-)-kappa(2)S,S']manganese
    manganese ethane-1,2-diyldicarbamodithioate manganese(+2) cation: [2-(sulfidocarbothioylamino)ethylamino]methanedi thioate manganese(2+) ethane-1,2-diylbis(dithiocarbamate)

    CAS Number 12427-38-2, 301-03-1, 8018-01-7
    PubChem Compound 3032581