MITOTOX

Drug

D1385 | Dyclonine

Molecular Formula	C18H27NO2
Molecular Weight	289.4
Structure
State	solid
Half life	Approximately 30 to 60 minutes.
Absorption	Readily absorbed through mucous membranes into the systemic circulation. The rate of absorption is influenced by the vascularity or rate of blood flow at the site of application, the total dosage (concentration and volume) administered, and the duration of exposure. Absorption from mucous membranes of the throat or respiratory tract may be especially rapid.
Trade names	Sucrets
Description	oral anaesthetic

R02AD04 Dyclonine

[R02AD] Anesthetics, local

[R02A] THROAT PREPARATIONS

[R02] THROAT PREPARATIONS

[R] Respiratory system

N01BX02 Dyclonine

[N01BX] Other local anesthetics

[N01B] ANESTHETICS, LOCAL

[N01] ANESTHETICS

[N] Nervous system

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
OXYGEN CONSUMPTION RATE (OCR)			mouse	neuron	Oxygen consumption rate (OCR) or extracellular acidification rate (ECAR) measurements from permeabilized neurons and isolated brain mitochondria were performed using the XF96 Extracellular Flux analyzer (Seahorse Bioscience).	increase		269
ELONGATION			mouse	neuron	Mitochondrial morphology and neurite area measurements	induce		269

Organism	Test type	Route	Dose (normalized dose)	Effect	Source
dog	LDLo	oral	40mg/kg (40mg/kg)		Toxicology and Applied Pharmacology. Vol. 2, Pg. 616, 1960.
rat	LD50	intraperitoneal	33mg/kg (33mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 708, 1958.
rat	LD50	subcutaneous	201mg/kg (201mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 413, 1955.
mouse	LD50	intraperitoneal	52mg/kg (52mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 410, 1962.
rabbit	LD50	oral	240mg/kg (240mg/kg)	behavioral: ataxia	Toxicology and Applied Pharmacology. Vol. 2, Pg. 616, 1960.
mouse	LD50	intravenous	20mg/kg (20mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 419, 1955.
dog	LD50	intravenous	9500ug/kg (9.5mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 419, 1955.
mouse	LDLo	oral	100mg/kg (100mg/kg)		Toxicology and Applied Pharmacology. Vol. 2, Pg. 616, 1960.
mouse	LD50	subcutaneous	37mg/kg (37mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 708, 1958.

078A24Q30O	1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone	1-(4-butoxyphenyl)-3-(piperidin-1-yl)propan-1-one
1-(4-butoxyphenyl)-3-piperidin-1-ylpropan-1-one	1-(4-butoxyphenyl)-3-piperidylpropan-1-one	1-Propanone, 1-(4-butoxyphenyl)-3-(1-piperidinyl)-
1-Propanone, 1-(4-butoxyphenyl)-3-(1-piperidinyl)- (9CI)	2-(1-piperidyl)ethyl p-butoxyphenyl ketone	3-Piperidino-4'-butoxypropiophenone
4'-Butoxy-3-piperidinopropiophenone	4-butoxy-beta-piperidinopropiophenone	4-n-butoxy-beta-(1-piperidyl)propiophenone
586-60-7	AB00053467	AB00053467_13
AB00053467_14	AC-12286	AKOS000505031
AMOT0928	API0009050	BPBio1_000120
BRD-K72259270-003-05-8	BRD-K72259270-003-15-7	BRN 0224037
BSPBio_000108	BSPBio_001940	C07881
CAS-536-43-6	CHEBI:4724	CHEMBL1201217
D07881	DB00645	DTXSID6047864
Diclonina [INN-Spanish]	DivK1c_000632	Dyclocaine
Dyclocainum	Dyclone (Salt/Mix)	Dyclonin
Dyclonine (INN)	Dyclonine [INN:BAN]	Dycloninum
Dycloninum [INN-Latin]	FT-0660914	GTPL7173
IDI1_000632	KBio1_000632	KBio2_001496
KBio2_004064	KBio2_006632	KBio3_001160
KBioGR_001137	KBioSS_001496	LS-125084
MCULE-1206604674	NCGC00016498-01	NCGC00016498-02
NCGC00016498-03	NCGC00016498-04	NCGC00016498-05
NINDS_000632	NS00010019	PROPIOPHENONE, 4'-BUTOXY-3-PIPERIDINO-
Prestwick0_000264	Prestwick1_000264	Prestwick2_000264
Prestwick3_000264	Q425386	S039
SBI-0051358.P003	SCHEMBL25773	SPBio_001165
SPBio_002327	ST095169	STK524544
Spectrum2_001013	Spectrum3_000410	Spectrum4_000529
Spectrum5_000951	Spectrum_001016	Tanaclone (Salt/Mix)
UNII-078A24Q30O	ZINC1530940	dyclonine
dyclonine hydrochloride;Dyclonine;dyclonine