Compound
D1413 | eperezolid
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MITOCHONDRIAL PROTEIN TRANSLATION | 9.5 ± 1.5 μM | Isolated rat heart mitochondria | Mitochondrial protein synthesis (MPS) assay with [35S]methionine | IC50 | 282 | |||
| MITOCHONDRIAL PROTEIN TRANSLATION | 4.2 ± 0.4 μM | rat | Isolated liver mitochondria | Mitochondrial protein synthesis assay (The incorporation of [35S]methionine into mitochondrial protein was determined by a filter paper disk assay ) | IC50 | 281 | ||
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| 39S ribosomal protein L3, mitochondrial | 4.2 ± 0.4 μM | rat | Isolated liver mitochondria | Mitochondrial protein synthesis assay (The incorporation of [35S]methionine into mitochondrial protein was determined by a filter paper disk assay ) | IC50 | 281 | ||
| CAS Number | 165800-04-4, 16905-14-9 |
| PubChem Compound | 73214 |